FRAT2

Description		FRAT regulator of Wnt signaling pathway 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol
	Molecular Function
	Biological Process	Wnt Signaling Pathway Regulation Of Protein Export From Nucleus Canonical Wnt Signaling Pathway
Pathways		Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane
Drugs
Diseases
GWAS		Body mass index ( 28892062) General risk tolerance (MTAG) ( 30643258) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Monocyte count ( 32888494)
Interacting Genes		12 interacting genes: BUB1 CDKN2A CTNNA1 EGFR ERBB2 GSK3B KRAS MCC MLH1 MLH3 NRAS PTPN12
Entrez ID		23401
HPRD ID		05419
Ensembl ID		ENSG00000181274
Uniprot IDs		O75474
PDB IDs
Enriched GO Terms of Interacting Partners?		Chiasma Intracellular Signal Transduction Negative Regulation Of Cell Differentiation Negative Regulation Of Immature T Cell Proliferation In Thymus Regulation Of Epithelial Cell Proliferation Cellular Response To Epidermal Growth Factor Stimulus Mismatch Repair Complex Response To Epidermal Growth Factor Negative Regulation Of Immature T Cell Proliferation Intracellular Signaling Cassette ERBB2-EGFR Signaling Pathway Negative Regulation Of Developmental Process Negative Regulation Of T Cell Differentiation In Thymus Ras Protein Signal Transduction Regulation Of Immature T Cell Proliferation In Thymus Negative Regulation Of Cell Development Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Mismatched DNA Binding Signal Transduction Regulation Of Cell Population Proliferation Nucleotide Binding Apoptotic Signaling Pathway Negative Regulation Of Multicellular Organismal Process ATP-dependent DNA Damage Sensor Activity Cell Population Proliferation Positive Regulation Of Protein Modification Process ERBB2 Signaling Pathway Regulation Of T Cell Differentiation In Thymus Regulation Of Cell Growth Synaptonemal Complex Regulation Of Cell Development Regulation Of Protein Localization To Nucleus Focal Adhesion ATP Binding Reciprocal Meiotic Recombination Regulation Of Signal Transduction NF-kappaB Binding Regulation Of Apoptotic Process Regulation Of Protein Localization Regulation Of Programmed Cell Death Regulation Of Multicellular Organismal Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Negative Regulation Of ERBB Signaling Pathway Mismatch Repair Condensed Chromosome Regulation Of Mitotic Cell Cycle Protein Kinase Activity Cytosol Regulation Of Cell Differentiation
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