FRAT2

Gene Name		frequently rearranged in advanced T-cell lymphomas 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Cytosol
	Molecular Function	Molecular_function
	Biological Process	Multicellular Organismal Development Cell Proliferation Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		misspliced GSK3beta mutants stabilize beta-catenin APC truncation mutants have impaired AXIN binding T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane S37 mutants of beta-catenin aren't phosphorylated Degradation of beta-catenin by the destruction complex RNF mutants show enhanced WNT signaling and proliferation S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling XAV939 inhibits tankyrase, stabilizing AXIN Beta-catenin phosphorylation cascade truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated deletions in the AMER1 gene destabilize the destruction complex TCF dependent signaling in response to WNT AMER1 mutants destabilize the destruction complex deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-protein Interactions		1 interactors: GSK3B
Entrez ID		23401
HPRD ID		05419
Ensembl ID		ENSG00000181274
Uniprot IDs		O75474
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Type B Pancreatic Cell Development Superior Temporal Gyrus Development Re-entry Into Mitotic Cell Cycle Negative Regulation Of Neuron Maturation Hypermethylation Of CpG Island Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Cellular Response To Interleukin-3 Regulation Of Neuron Maturation Negative Regulation Of Glycogen (starch) Synthase Activity Protein Localization To Microtubule Negative Regulation Of Dendrite Morphogenesis Negative Regulation Of NFAT Protein Import Into Nucleus ER Overload Response Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Muscle Hypertrophy Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Protein Export From Nucleus Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Dendrite Development Regulation Of DNA Methylation Myoblast Fusion Protein Localization To Cytoskeleton Regulation Of Gene Expression By Genetic Imprinting Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Response To Lithium Ion Regulation Of Cellular Response To Heat Regulation Of Cardiac Muscle Hypertrophy Regulation Of Protein Export From Nucleus Regulation Of Glycogen Biosynthetic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Syncytium Formation Genetic Imprinting Negative Regulation Of Epithelial Cell Differentiation Protein Export From Nucleus Regulation Of Glycogen Metabolic Process Positive Regulation Of Axon Extension Negative Regulation Of Transcription Factor Import Into Nucleus Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Stem Cell Differentiation Positive Regulation Of Cell-matrix Adhesion Negative Regulation Of Protein Binding Epithelial To Mesenchymal Transition Positive Regulation Of Rac GTPase Activity Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Mitochondrion Organization Myotube Differentiation Glycogen Metabolic Process Cellular Response To Heat
Tagcloud ?		10q24 13q13 13q14 17p13 3p13 3p22 6p22 9q21 arhgap19 array asian caucasian cgh chromogenic cish concordance copy database dissect harboring helps imbalance invaluable metacore pafah1b1 qpcr racial revealing znf322a