FRAT2 and MCC

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		FRAT2	MCC
Description		FRAT regulator of Wnt signaling pathway 2	MCC regulator of Wnt signaling pathway
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Lamellipodium Cell Projection
	Molecular Function		Protein Binding Signaling Receptor Activity
	Biological Process	Wnt Signaling Pathway Regulation Of Protein Export From Nucleus Canonical Wnt Signaling Pathway	Signal Transduction Negative Regulation Of Epithelial Cell Migration Wnt Signaling Pathway Establishment Of Protein Localization Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane
Drugs
Diseases
GWAS		Body mass index ( 28892062) General risk tolerance (MTAG) ( 30643258) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Monocyte count ( 32888494)	Adult body size ( 32376654) Brain cytoarchitecture ( 20308991) Cerebral amyloid angiopathy ( 25188341) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 31562340) Metabolite levels ( 23823483) Neurofibrillary tangles ( 31497858) Nicotine dependence symptom count ( 25555482) Triglyceride levels ( 32203549) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		12 interacting genes: BUB1 CDKN2A CTNNA1 EGFR ERBB2 GSK3B KRAS MCC MLH1 MLH3 NRAS PTPN12	77 interacting genes: ALDOB ANP32B APP BAAT C8orf33 C8orf48 CBX5 CBX8 CCDC112 CCDC146 CCDC180 CCDC185 CCDC187 CDC14B CDK8 CDKL3 CEP57L1 CEP95 CFAP58 CYLC2 DNAAF4 DYNC1I1 ELOA ERBIN ESRRG FAM161A FGF16 FRAT2 GTF2E2 HEMGN HSD17B3 KAT5 KEAP1 KIF3C KIFC3 LRRC45 MSANTD3 MTNR1A NANS NEK2 NFKBIB NOL12 PCCA PNKP POLL PRPF18 RASAL2 RCOR3 SEC61B SFRP4 SLTM SLU7 SYT17 SYT6 TCEA2 TCEANC TGFB1 THAP7 TRMO TRMT2A TSHZ2 TSTD2 TXLNA UTP14C ZBTB48 ZNF12 ZNF189 ZNF202 ZNF264 ZNF3 ZNF35 ZNF417 ZNF438 ZNF497 ZNF543 ZNF648 ZNF792
Entrez ID		23401	4163
HPRD ID		05419	01157
Ensembl ID		ENSG00000181274	ENSG00000171444
Uniprot IDs		O75474	P23508
PDB IDs			6MTU 6MTV
Enriched GO Terms of Interacting Partners?		Chiasma Intracellular Signal Transduction Negative Regulation Of Cell Differentiation Negative Regulation Of Immature T Cell Proliferation In Thymus Regulation Of Epithelial Cell Proliferation Cellular Response To Epidermal Growth Factor Stimulus Mismatch Repair Complex Response To Epidermal Growth Factor Negative Regulation Of Immature T Cell Proliferation Intracellular Signaling Cassette ERBB2-EGFR Signaling Pathway Negative Regulation Of Developmental Process Negative Regulation Of T Cell Differentiation In Thymus Ras Protein Signal Transduction Regulation Of Immature T Cell Proliferation In Thymus Negative Regulation Of Cell Development Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Mismatched DNA Binding Signal Transduction Regulation Of Cell Population Proliferation Nucleotide Binding Apoptotic Signaling Pathway Negative Regulation Of Multicellular Organismal Process ATP-dependent DNA Damage Sensor Activity Cell Population Proliferation Positive Regulation Of Protein Modification Process ERBB2 Signaling Pathway Regulation Of T Cell Differentiation In Thymus Regulation Of Cell Growth Synaptonemal Complex Regulation Of Cell Development Regulation Of Protein Localization To Nucleus Focal Adhesion ATP Binding Reciprocal Meiotic Recombination Regulation Of Signal Transduction NF-kappaB Binding Regulation Of Apoptotic Process Regulation Of Protein Localization Regulation Of Programmed Cell Death Regulation Of Multicellular Organismal Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Negative Regulation Of ERBB Signaling Pathway Mismatch Repair Condensed Chromosome Regulation Of Mitotic Cell Cycle Protein Kinase Activity Cytosol Regulation Of Cell Differentiation	Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Centrosome
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