CCDC180 and FLCN

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		CCDC180	FLCN
Description		coiled-coil domain containing 180	folliculin
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Exosome	Nucleus Cytoplasm Lysosome Lysosomal Membrane Centrosome Spindle Cytosol Cytoskeleton Plasma Membrane Cilium Membrane Midbody Cell Projection Cell-cell Contact Zone Mitotic Spindle FNIP-folliculin RagC/D GAP
	Molecular Function		Enzyme Inhibitor Activity GTPase Activator Activity Protein Binding Enzyme Binding Protein-containing Complex Binding
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Lysosome Organization Cell-cell Junction Assembly Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Positive Regulation Of Autophagy Hemopoiesis Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Cellular Response To Nutrient Levels TOR Signaling Regulation Of TOR Signaling Negative Regulation Of TOR Signaling Positive Regulation Of TOR Signaling Lysosome Localization Cellular Response To Amino Acid Starvation Negative Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction TORC1 Signaling Positive Regulation Of Apoptotic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Glycolytic Process Negative Regulation Of DNA-templated Transcription Regulation Of Ras Protein Signal Transduction Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade Cell Proliferation Involved In Kidney Development Energy Homeostasis Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Cell Proliferation Involved In Kidney Development Negative Regulation Of Post-translational Protein Modification Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Brown Fat Cell Differentiation Positive Regulation Of TORC1 Signaling Negative Regulation Of Lysosome Organization Regulation Of Pro-B Cell Differentiation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways			Amino acids regulate mTORC1
Drugs
Diseases			Birt-Hogg-Dube syndrome Renal cell carcinoma
GWAS			Heel bone mineral density ( 30598549) Mean reticulocyte volume ( 32888494)
Interacting Genes		21 interacting genes: BCL10 BUB1 CDKN2A CTNNA1 DLC1 ERBB2 FLCN MCC MECOM MLH1 MLH3 MSH2 NRAS PDGFRL PMS2 PTEN PTPN12 RB1 SMAD4 SRC STK11	12 interacting genes: ALDOB APP CCDC180 FBP1 GABARAP HEMGN HSP90AA1 MAP1LC3B NANS RRAGA TMEFF1 TSTD2
Entrez ID		100499483	201163
HPRD ID			06278
Ensembl ID		ENSG00000197816	ENSG00000154803
Uniprot IDs		A0A6E1Y6F7 B4DZK1 Q9P1Z9	A0A0S2Z5Y7 Q8NFG4
PDB IDs			3V42 6NZD 6ULG 8DHB
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Mismatched DNA Binding Apoptotic Signaling Pathway Negative Regulation Of Cell Population Proliferation ATP-dependent DNA Damage Sensor Activity Mismatch Repair Complex Positive Regulation Of Isotype Switching To IgA Isotypes Mismatch Repair Signal Transduction Negative Regulation Of Cell-matrix Adhesion Regulation Of Phosphorus Metabolic Process Regulation Of Epithelial Cell Proliferation Negative Regulation Of Signal Transduction Positive Regulation Of Isotype Switching To IgG Isotypes Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Multicellular Organismal Process Regulation Of Protein Modification Process Regulation Of Phosphorylation Somatic Hypermutation Of Immunoglobulin Genes Nucleus Somatic Diversification Of Immune Receptors Via Somatic Mutation Regulation Of Multicellular Organismal Process Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cell-substrate Adhesion Regulation Of Signal Transduction Regulation Of Cell Population Proliferation Regulation Of Protein Localization To Nucleus Cell Population Proliferation Chiasma Negative Regulation Of Focal Adhesion Assembly Regulation Of Lymphocyte Activation Regulation Of Apoptotic Process Nucleoplasm Cytosol Intracellular Signaling Cassette MutLalpha Complex Regulation Of Cell Communication Regulation Of Signaling Regulation Of Developmental Process Regulation Of Protein Phosphorylation Positive Regulation Of Isotype Switching Apoptotic Process Negative Regulation Of Growth Positive Regulation Of Nucleobase-containing Compound Metabolic Process Programmed Cell Death Regulation Of Cell Activation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway	Fructose Metabolic Process Regulation Of Carbohydrate Catabolic Process Fructose 1,6-bisphosphate Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Ubiquitin Protein Ligase Binding Autophagosome Organization Autophagosome Assembly Phosphatidylethanolamine Binding Cellular Response To Nitrogen Starvation Carbohydrate Biosynthetic Process Response To Salt Stress Regulation Of Generation Of Precursor Metabolites And Energy Vacuole Organization Response To Nutrient Levels Cellular Response To Starvation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Nitric Oxide Metabolic Process Gluconeogenesis Hexose Biosynthetic Process Fructose-1-phosphate Aldolase Activity Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Response To CAMP CTP Binding DATP Binding Response To Starvation Cellular Response To Nutrient Levels Autophagosome Membrane Autophagosome Maturation N-acetylneuraminate Synthase Activity N-acylneuraminate-9-phosphate Synthase Activity Mitophagy Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Autophagy Regulation Of Small Molecule Metabolic Process Negative Regulation Of Pentose-phosphate Shunt Acetylcholine Receptor Activator Activity Regulation Of ATP Metabolic Process Lipoprotein Particle Positive Regulation Of Protein Import Response To Osmotic Stress Phosphoric Ester Hydrolase Activity Cellular Response To Raffinose Fructose 1,6-bisphosphate 1-phosphatase Activity
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