CCDC180 and PMS2

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		CCDC180	PMS2
Description		coiled-coil domain containing 180	PMS1 homolog 2, mismatch repair system component
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Exosome	Nucleus Nucleoplasm Cytosol Mismatch Repair Complex MutLalpha Complex
	Molecular Function		Nucleotide Binding DNA Binding Single-stranded DNA Binding Nuclease Activity Endonuclease Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Mismatched DNA Binding Single Base Insertion Or Deletion Binding MutSalpha Complex Binding ATP-dependent DNA Damage Sensor Activity
	Biological Process		DNA Repair Mismatch Repair DNA Damage Response Response To Xenobiotic Stimulus Somatic Hypermutation Of Immunoglobulin Genes Somatic Recombination Of Immunoglobulin Gene Segments Positive Regulation Of Isotype Switching To IgA Isotypes Positive Regulation Of Isotype Switching To IgG Isotypes
Pathways			Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Defective Mismatch Repair Associated With MLH1 Defective Mismatch Repair Associated With PMS2 TP53 Regulates Transcription of DNA Repair Genes
Drugs			Adenosine 5'-[gamma-thio]triphosphate
Diseases			Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
GWAS
Interacting Genes		21 interacting genes: BCL10 BUB1 CDKN2A CTNNA1 DLC1 ERBB2 FLCN MCC MECOM MLH1 MLH3 MSH2 NRAS PDGFRL PMS2 PTEN PTPN12 RB1 SMAD4 SRC STK11	18 interacting genes: AKT1 ANP32B CCDC180 CRYAA EXO1 FANCC GALNT12 MEOX2 MLH1 PCNA PPP2CB RASA1 SFRP4 TRMO UBC VPS26C XPA ZNF189
Entrez ID		100499483	5395
HPRD ID			02598
Ensembl ID		ENSG00000197816	ENSG00000122512
Uniprot IDs		A0A6E1Y6F7 B4DZK1 Q9P1Z9	A0A2R8Y6S3 A0A8V8TNX6 A0A8V8TNY8 A0A8V8TP61 A0A8V8TP84 A0A8V8TPE1 A0A8V8TQ50 A0A8V8TQ92 A0A8V8TQG9 A0A8V8TQI1 A0A8V8TQS5 B4DGM0 C9J167 P54278
PDB IDs			1EA6 1H7S 1H7U 5U5R 6MFQ 7RCB 7RCI 7RCK
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Mismatched DNA Binding Apoptotic Signaling Pathway Negative Regulation Of Cell Population Proliferation ATP-dependent DNA Damage Sensor Activity Mismatch Repair Complex Positive Regulation Of Isotype Switching To IgA Isotypes Mismatch Repair Signal Transduction Negative Regulation Of Cell-matrix Adhesion Regulation Of Phosphorus Metabolic Process Regulation Of Epithelial Cell Proliferation Negative Regulation Of Signal Transduction Positive Regulation Of Isotype Switching To IgG Isotypes Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Multicellular Organismal Process Regulation Of Protein Modification Process Regulation Of Phosphorylation Somatic Hypermutation Of Immunoglobulin Genes Nucleus Somatic Diversification Of Immune Receptors Via Somatic Mutation Regulation Of Multicellular Organismal Process Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cell-substrate Adhesion Regulation Of Signal Transduction Regulation Of Cell Population Proliferation Regulation Of Protein Localization To Nucleus Cell Population Proliferation Chiasma Negative Regulation Of Focal Adhesion Assembly Regulation Of Lymphocyte Activation Regulation Of Apoptotic Process Nucleoplasm Cytosol Intracellular Signaling Cassette MutLalpha Complex Regulation Of Cell Communication Regulation Of Signaling Regulation Of Developmental Process Regulation Of Protein Phosphorylation Positive Regulation Of Isotype Switching Apoptotic Process Negative Regulation Of Growth Positive Regulation Of Nucleobase-containing Compound Metabolic Process Programmed Cell Death Regulation Of Cell Activation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway	Response To Oxidative Stress Positive Regulation Of Deoxyribonuclease Activity Mismatch Repair Response To UV Response To UV-A Somatic Hypermutation Of Immunoglobulin Genes Somatic Diversification Of Immune Receptors Via Somatic Mutation Response To Hydrogen Peroxide DNA Repair Response To Light Stimulus Isotype Switching Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Somatic Diversification Of Immunoglobulins Involved In Immune Response Cellular Response To Stress Enzyme Binding TRNA Methylation Nucleus Regulation Of TRNA Methylation Response To Radiation Response To Reactive Oxygen Species DNA Metabolic Process DNA Damage Response Somatic Recombination Of Immunoglobulin Gene Segments Somatic Cell DNA Recombination Late Recombination Nodule Somatic Diversification Of Immunoglobulins Meiotic Metaphase I Homologous Chromosome Alignment PCNA Complex Replisome Negative Regulation Of Sodium-dependent Phosphate Transport Nucleotide-excision Repair, DNA Damage Recognition Double-stranded DNA 5'-3' DNA Exonuclease Activity TRNA (L-threonylcarbamoyladenosine(37)-C2) Methyltransferase Activity Male Germ Cell Nucleus Nucleotide-excision Repair
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