CCDC180 and DLC1

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		CCDC180	DLC1
Description		coiled-coil domain containing 180	DLC1 Rho GTPase activating protein
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Exosome	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Caveola Focal Adhesion Membrane Cortical Actin Cytoskeleton Ruffle Membrane Membrane Raft Anchoring Junction
	Molecular Function		GTPase Activator Activity Protein Binding Lipid Binding SH2 Domain Binding
	Biological Process		Neural Tube Closure Heart Morphogenesis Signal Transduction Negative Regulation Of Cell Population Proliferation Hindbrain Morphogenesis Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Forebrain Development Regulation Of Rho Protein Signal Transduction Negative Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Focal Adhesion Assembly Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Stress Fiber Assembly Negative Regulation Of Focal Adhesion Assembly Positive Regulation Of Execution Phase Of Apoptosis
Pathways			RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOQ GTPase cycle
Drugs
Diseases
GWAS			Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Attention deficit hyperactivity disorder ( 30563984) Bipolar disorder ( 22688191) Emphysema imaging phenotypes ( 26030696) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Familial hepatitis B virus-related hepatocellular carcinoma ( 28662289) Fractional exhaled nitric oxide (childhood) ( 24315451) Gestational age at birth (child effect) ( 31194736) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Heel bone mineral density ( 30598549) Height ( 31562340) Intraocular pressure ( 29617998) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Late-onset Alzheimer's disease ( 27770636) LDL cholesterol levels in HIV infection ( 33109212) Lung adenocarcinoma ( 28604730) Metabolite levels ( 23823483) Mild obesity-related type 2 diabetes ( 34737425) Nicotine dependence symptom count ( 25555482) Nose size ( 27182965) Obesity-related traits ( 23251661) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507) Percentage gas trapping ( 26030696) Platelet distribution width ( 32888494) PR interval ( 32439900) Refractive error ( 32231278) Smoking initiation (ever regular vs never regular) ( 31089300) Waist-hip ratio ( 28552196)
Interacting Genes		21 interacting genes: BCL10 BUB1 CDKN2A CTNNA1 DLC1 ERBB2 FLCN MCC MECOM MLH1 MLH3 MSH2 NRAS PDGFRL PMS2 PTEN PTPN12 RB1 SMAD4 SRC STK11	35 interacting genes: ACOT7 AKT1 AOPEP BAAT CCDC180 CDC14B CORO2A CTSV FANCC FBP2 HEMGN HSD17B3 MAPK3 PFKM PKM PPP3R2 PTEN RANGAP1 RASA1 RHOA RPS6KA1 SFRP4 SMAD1 STX17 TDRD7 TGFB1 TMEFF1 TMEM129 TMOD1 TNS2 TRMO USP4 XPA ZNF189 ZNF510
Entrez ID		100499483	10395
HPRD ID			05035
Ensembl ID		ENSG00000197816	ENSG00000164741
Uniprot IDs		A0A6E1Y6F7 B4DZK1 Q9P1Z9	A8K119 Q96QB1
PDB IDs			2DKY 2GYT 2KAP 2LOZ 3KUQ 5FZT 7TPB
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Mismatched DNA Binding Apoptotic Signaling Pathway Negative Regulation Of Cell Population Proliferation ATP-dependent DNA Damage Sensor Activity Mismatch Repair Complex Positive Regulation Of Isotype Switching To IgA Isotypes Mismatch Repair Signal Transduction Negative Regulation Of Cell-matrix Adhesion Regulation Of Phosphorus Metabolic Process Regulation Of Epithelial Cell Proliferation Negative Regulation Of Signal Transduction Positive Regulation Of Isotype Switching To IgG Isotypes Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Multicellular Organismal Process Regulation Of Protein Modification Process Regulation Of Phosphorylation Somatic Hypermutation Of Immunoglobulin Genes Nucleus Somatic Diversification Of Immune Receptors Via Somatic Mutation Regulation Of Multicellular Organismal Process Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cell-substrate Adhesion Regulation Of Signal Transduction Regulation Of Cell Population Proliferation Regulation Of Protein Localization To Nucleus Cell Population Proliferation Chiasma Negative Regulation Of Focal Adhesion Assembly Regulation Of Lymphocyte Activation Regulation Of Apoptotic Process Nucleoplasm Cytosol Intracellular Signaling Cassette MutLalpha Complex Regulation Of Cell Communication Regulation Of Signaling Regulation Of Developmental Process Regulation Of Protein Phosphorylation Positive Regulation Of Isotype Switching Apoptotic Process Negative Regulation Of Growth Positive Regulation Of Nucleobase-containing Compound Metabolic Process Programmed Cell Death Regulation Of Cell Activation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway	Phosphate-containing Compound Metabolic Process TORC1 Signaling Negative Regulation Of TOR Signaling TOR Signaling Negative Regulation Of Cell Adhesion Negative Regulation Of Transport Glucose Metabolic Process Negative Regulation Of Cell Size Thiolester Hydrolase Activity Fructose 1,6-bisphosphate Metabolic Process Intracellular Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of TORC1 Signaling Regulation Of Transcription By RNA Polymerase II Regulation Of TOR Signaling Hexose Metabolic Process Regulation Of Mononuclear Cell Migration Negative Regulation Of Cell-substrate Adhesion Long-chain Fatty Acyl-CoA Hydrolase Activity Fructose 6-phosphate Metabolic Process Negative Regulation Of Immune Response To Tumor Cell Myelin Maintenance Fatty Acyl-CoA Hydrolase Activity Lens Fiber Cell Differentiation Positive Regulation Of Catalytic Activity Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Fibroblast Migration Monosaccharide Metabolic Process Regulation Of Exit From Mitosis
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