GFI1 and PIAS2

Number of citations of the paper that reports this interaction (PMID 19164764)
13

Data Source:
BioGRID (pull down, affinity chromatography technology)

		GFI1	PIAS2
Gene Name		growth factor independent 1 transcription repressor	protein inhibitor of activated STAT, 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nuclear Matrix Nuclear Body Transcriptional Repressor Complex	Nucleus PML Body Nuclear Speck
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Protein Binding Zinc Ion Binding Transcription Regulatory Region DNA Binding	DNA Binding Transcription Coactivator Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Binding Androgen Receptor Binding SUMO Ligase Activity
	Biological Process	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Mechanosensory Behavior Negative Regulation Of Cell Fate Specification Negative Regulation Of Calcidiol 1-monooxygenase Activity Negative Regulation Of Vitamin D Biosynthetic Process Negative Regulation Of Neuron Projection Development Viral Process Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Toll-like Receptor Signaling Pathway Inner Ear Morphogenesis Auditory Receptor Cell Differentiation Positive Regulation Of Cell Fate Specification Cell Fate Commitment Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Interleukin-6-mediated Signaling Pathway Cellular Response To Lipopolysaccharide	Transcription, DNA-templated Protein Sumoylation Androgen Receptor Signaling Pathway Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Androgen Receptor Signaling Pathway
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: PIAS2 PIAS3 PICK1 RUNX1T1 SPI1	68 interactors: ACY3 ADA AKT1 AR C1QA CCHCR1 CCNDBP1 CHMP4B CLDN2 CTBP1 DDX39B ELK1 ESR1 ESR2 FLI1 GFAP GFI1 GLUL GOLGA2 GRM8 GTF2I GTF2IRD1 HDAC3 HUWE1 ITGB5 JUN MAPK8 MAPKAPK2 MBD1 MITF MSX2 MX2 MYCN NAV2 NR3C1 PARK7 PAXIP1 PGR PHC1 PIAS1 PIAS4 PLAG1 PLAGL1 PML PRKAB2 RUFY1 SIAH1 SIAH2 SMAD3 SMAD4 SNIP1 SREBF2 STAT4 SUMO1 SUMO1P1 SUMO2 SUMO3 TICAM2 TP53 TRIM23 TRIM27 TRIM55 TRIM63 TSR2 UBE2I ZBED1 ZBTB8A ZNF451
Entrez ID		2672	9063
HPRD ID		07527	06944
Ensembl ID		ENSG00000162676	ENSG00000078043
Uniprot IDs		B3KVN4 Q99684	O75928
PDB IDs			2ASQ 4FO9
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Peptidyl-lysine Modification Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process RNA Biosynthetic Process Peptidyl-amino Acid Modification Positive Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Gene Expression, Epigenetic Hypermethylation Of CpG Island Negative Regulation Of MHC Class II Biosynthetic Process RNA Metabolic Process DNA Methylation Involved In Embryo Development Cellular Protein Modification Process Apoptotic Process Involved In Patterning Of Blood Vessels Negative Regulation Of Histone H4 Acetylation Dendritic Spine Maintenance Positive Regulation Of Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Lymphoid Progenitor Cell Differentiation Neuronal Ion Channel Clustering Positive Regulation Of Gene Expression Macromolecule Biosynthetic Process Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Protein Sumoylation Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Actin Nucleation Regulation Of Metabolic Process Granulocyte Differentiation Regulation Of Histone H4 Acetylation Long Term Synaptic Depression Anatomical Structure Regression Positive Regulation Of Receptor Internalization Regulation Of Protein Sumoylation Macrophage Differentiation Regulation Of DNA Methylation Negative Regulation Of Histone Acetylation Regulation Of Androgen Receptor Signaling Pathway Regulation Of Arp2/3 Complex-mediated Actin Nucleation Dendritic Spine Organization Regulation Of Transcription, DNA-templated Negative Regulation Of Peptidyl-lysine Acetylation DNA Methylation Involved In Gamete Generation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Transcription, DNA-templated Response To Organic Substance RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated RNA Metabolic Process Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Protein Sumoylation Negative Regulation Of Nucleic Acid-templated Transcription Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Cell Death Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Gland Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Protein Modification By Small Protein Conjugation Cellular Response To Lipid Macromolecule Biosynthetic Process Cellular Response To Stimulus Regulation Of Cellular Process Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Cellular Metabolic Process Cellular Response To Organic Cyclic Compound Regulation Of Cell Proliferation Regulation Of Signaling Signaling
Tagcloud ?		cdc2 cdkn1b consequence crosstalk cyr61 decade description endometrial erb erk1 genomic implantation jund mimics peri picomolar pr progesterone progestin progestins r5020 represented repressors steroid stromal take uiii usf1 verified	293t acts alphaclass androgen ar chaperone clone27 coimmunoprecipitation colocalization coregulator cytoplasm e3 factorkappab hek hela libraries ligase modulates prefoldintype sumoylation termed transcript transducer trapped twohybrid ubiquitously uxt yeast
Tagcloud (Difference) ?		cdc2 cdkn1b consequence crosstalk cyr61 decade description endometrial erb erk1 genomic implantation jund mimics peri picomolar pr progesterone progestin progestins r5020 represented repressors steroid stromal take uiii usf1 verified	293t acts alphaclass androgen ar chaperone clone27 coimmunoprecipitation colocalization coregulator cytoplasm e3 factorkappab hek hela libraries ligase modulates prefoldintype sumoylation termed transcript transducer trapped twohybrid ubiquitously uxt yeast
Tagcloud (Intersection) ?