GFI1 and PICK1

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GFI1	PICK1
Gene Name		growth factor independent 1 transcription repressor	protein interacting with PRKCA 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nuclear Matrix Nuclear Body Transcriptional Repressor Complex	Cytoplasm Mitochondrion Golgi Apparatus Cytoskeleton Plasma Membrane Cell Junction Endocytic Vesicle Membrane Presynaptic Membrane Neuron Projection Synapse Postsynaptic Membrane Perinuclear Region Of Cytoplasm Neuronal Postsynaptic Density
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Protein Binding Zinc Ion Binding Transcription Regulatory Region DNA Binding	G-protein Coupled Receptor Binding Protein Kinase C Binding Receptor Binding Protein Binding Protein C-terminus Binding ATPase Activity Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Metal Ion Binding Actin Filament Binding Arp2/3 Complex Binding
	Biological Process	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Mechanosensory Behavior Negative Regulation Of Cell Fate Specification Negative Regulation Of Calcidiol 1-monooxygenase Activity Negative Regulation Of Vitamin D Biosynthetic Process Negative Regulation Of Neuron Projection Development Viral Process Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Toll-like Receptor Signaling Pathway Inner Ear Morphogenesis Auditory Receptor Cell Differentiation Positive Regulation Of Cell Fate Specification Cell Fate Commitment Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Interleukin-6-mediated Signaling Pathway Cellular Response To Lipopolysaccharide	Positive Regulation Of Receptor Internalization Protein Phosphorylation Protein Targeting Retrograde Vesicle-mediated Transport, Golgi To ER Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Synaptic Transmission Monoamine Transport Glial Cell Development Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cellular Response To Decreased Oxygen Levels Cellular Response To Glucose Starvation DNA Methylation Involved In Embryo Development DNA Methylation Involved In Gamete Generation Receptor Clustering Neuronal Ion Channel Clustering Long Term Synaptic Depression Dendritic Spine Organization Dendritic Spine Maintenance
Pathways			Trafficking of GluR2-containing AMPA receptors Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Trafficking of AMPA receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Transmission across Chemical Synapses
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: PIAS2 PIAS3 PICK1 RUNX1T1 SPI1	47 interactors: APTX AQP1 ARF1 ARF3 ASIC1 ASIC2 ATXN1L ATXN3 ATXN7 ATXN7L3 BTG2 CIC COIL CTNNB1 EFNB1 EFNB2 EHD2 EPHB2 ERBB2 ERBB2IP F11R FXN GFI1 GFI1B GRIA1 GRIA2 GRIA3 GRIA4 GRIK1 GRIK2 GRIK3 GRIP1 GRM3 GRM7 JAM3 LRP2BP MLLT4 PARK2 PRKCA PRKCG PRLHR PVRL2 PVRL4 SACS SLC6A3 UBQLN4 USP7
Entrez ID		2672	9463
HPRD ID		07527	16176
Ensembl ID		ENSG00000162676	ENSG00000100151
Uniprot IDs		B3KVN4 Q99684	B3KS52 Q9NRD5
PDB IDs			2GZV
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Peptidyl-lysine Modification Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process RNA Biosynthetic Process Peptidyl-amino Acid Modification Positive Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Gene Expression, Epigenetic Hypermethylation Of CpG Island Negative Regulation Of MHC Class II Biosynthetic Process RNA Metabolic Process DNA Methylation Involved In Embryo Development Cellular Protein Modification Process Apoptotic Process Involved In Patterning Of Blood Vessels Negative Regulation Of Histone H4 Acetylation Dendritic Spine Maintenance Positive Regulation Of Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Lymphoid Progenitor Cell Differentiation Neuronal Ion Channel Clustering Positive Regulation Of Gene Expression Macromolecule Biosynthetic Process Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Protein Sumoylation Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Actin Nucleation Regulation Of Metabolic Process Granulocyte Differentiation Regulation Of Histone H4 Acetylation Long Term Synaptic Depression Anatomical Structure Regression Positive Regulation Of Receptor Internalization Regulation Of Protein Sumoylation Macrophage Differentiation Regulation Of DNA Methylation Negative Regulation Of Histone Acetylation Regulation Of Androgen Receptor Signaling Pathway Regulation Of Arp2/3 Complex-mediated Actin Nucleation Dendritic Spine Organization Regulation Of Transcription, DNA-templated Negative Regulation Of Peptidyl-lysine Acetylation DNA Methylation Involved In Gamete Generation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process	Cell-cell Signaling Synaptic Transmission Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Neuron-neuron Synaptic Transmission Cellular Response To Stimulus Regulation Of Cellular Process Response To Stimulus Signaling Cell Communication Behavior Regulation Of Synaptic Transmission Single-organism Behavior Neurological System Process Negative Regulation Of Synaptic Transmission Regulation Of Synaptic Transmission, Glutamatergic Signal Transduction Adenylate Cyclase-inhibiting G-protein Coupled Glutamate Receptor Signaling Pathway Anatomical Structure Development Cell Surface Receptor Signaling Pathway Regulation Of Cellular Component Organization Nervous System Development Negative Regulation Of Synaptic Transmission, Glutamatergic Cell Junction Assembly Developmental Process Ion Transport Cell-cell Junction Organization Ion Transmembrane Transport G-protein Coupled Glutamate Receptor Signaling Pathway Histone Deubiquitination Learning Or Memory Negative Regulation Of Adenylate Cyclase Activity Multicellular Organismal Development Regulation Of Body Fluid Levels Negative Regulation Of Lyase Activity Establishment Of Endothelial Barrier Cognition Response To External Stimulus System Development Regulation Of Signaling Adherens Junction Organization Multicellular Organismal Response To Stress Negative Regulation Of CAMP Biosynthetic Process Cellular Process Negative Regulation Of CAMP Metabolic Process Sensory Perception Of Sour Taste Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Death Negative Regulation Of Programmed Cell Death
Tagcloud ?		cdc2 cdkn1b consequence crosstalk cyr61 decade description endometrial erb erk1 genomic implantation jund mimics peri picomolar pr progesterone progestin progestins r5020 represented repressors steroid stromal take uiii usf1 verified	altering ampa calsyntenin clarified confirming coordinated deprivation elicited excitotoxic glua1 glun2a glun2b glun3a grip1 hippocampal insults ionotropic ischemia ogd profound proteome repression sapap2 snap submitted synaptic tarpgamma3 transcriptome vulnerability
Tagcloud (Difference) ?		cdc2 cdkn1b consequence crosstalk cyr61 decade description endometrial erb erk1 genomic implantation jund mimics peri picomolar pr progesterone progestin progestins r5020 represented repressors steroid stromal take uiii usf1 verified	altering ampa calsyntenin clarified confirming coordinated deprivation elicited excitotoxic glua1 glun2a glun2b glun3a grip1 hippocampal insults ionotropic ischemia ogd profound proteome repression sapap2 snap submitted synaptic tarpgamma3 transcriptome vulnerability
Tagcloud (Intersection) ?