GFI1 and SPI1

Number of citations of the paper that reports this interaction (PMID 17197705)
17

Data Source:
BioGRID (affinity chromatography technology, pull down)

		GFI1	SPI1
Gene Name		growth factor independent 1 transcription repressor	Spi-1 proto-oncogene
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nuclear Matrix Nuclear Body Transcriptional Repressor Complex	Nuclear Chromatin
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Protein Binding Zinc Ion Binding Transcription Regulatory Region DNA Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Core Promoter Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Transcription Factor Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity RNA Binding Protein Binding NFAT Protein Binding
	Biological Process	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Mechanosensory Behavior Negative Regulation Of Cell Fate Specification Negative Regulation Of Calcidiol 1-monooxygenase Activity Negative Regulation Of Vitamin D Biosynthetic Process Negative Regulation Of Neuron Projection Development Viral Process Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Toll-like Receptor Signaling Pathway Inner Ear Morphogenesis Auditory Receptor Cell Differentiation Positive Regulation Of Cell Fate Specification Cell Fate Commitment Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Interleukin-6-mediated Signaling Pathway Cellular Response To Lipopolysaccharide	Negative Regulation Of Transcription From RNA Polymerase II Promoter Lymphoid Progenitor Cell Differentiation Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Lymphocyte Differentiation Erythrocyte Differentiation Macrophage Differentiation Granulocyte Differentiation Somatic Stem Cell Maintenance Myeloid Dendritic Cell Differentiation Histone H3 Acetylation Hypermethylation Of CpG Island Negative Regulation Of MHC Class II Biosynthetic Process Regulation Of Erythrocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Regression Negative Regulation Of Histone H4 Acetylation Apoptotic Process Involved In Patterning Of Blood Vessels
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: PIAS2 PIAS3 PICK1 RUNX1T1 SPI1	43 interactors: ATF1 BCL6 CEBPA CEBPB CEBPD CEBPE CREBBP CREM CSNK2A1 DNMT3A DNMT3B ERG ETS1 ETS2 ETV1 FOS FUS GATA1 GATA2 GATA3 GFI1 HDAC1 HOXA10 IRF1 IRF4 IRF8 JUN KAT6A MAPK8 MECP2 MITF NFATC1 NFKB1 NFYA NONO PIP RB1 SIN3A SKI SPIB SSRP1 TBP TMX1
Entrez ID		2672	6688
HPRD ID		07527	01305
Ensembl ID		ENSG00000162676	ENSG00000066336
Uniprot IDs		B3KVN4 Q99684	P17947
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Peptidyl-lysine Modification Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process RNA Biosynthetic Process Peptidyl-amino Acid Modification Positive Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Gene Expression, Epigenetic Hypermethylation Of CpG Island Negative Regulation Of MHC Class II Biosynthetic Process RNA Metabolic Process DNA Methylation Involved In Embryo Development Cellular Protein Modification Process Apoptotic Process Involved In Patterning Of Blood Vessels Negative Regulation Of Histone H4 Acetylation Dendritic Spine Maintenance Positive Regulation Of Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Lymphoid Progenitor Cell Differentiation Neuronal Ion Channel Clustering Positive Regulation Of Gene Expression Macromolecule Biosynthetic Process Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Protein Sumoylation Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Actin Nucleation Regulation Of Metabolic Process Granulocyte Differentiation Regulation Of Histone H4 Acetylation Long Term Synaptic Depression Anatomical Structure Regression Positive Regulation Of Receptor Internalization Regulation Of Protein Sumoylation Macrophage Differentiation Regulation Of DNA Methylation Negative Regulation Of Histone Acetylation Regulation Of Androgen Receptor Signaling Pathway Regulation Of Arp2/3 Complex-mediated Actin Nucleation Dendritic Spine Organization Regulation Of Transcription, DNA-templated Negative Regulation Of Peptidyl-lysine Acetylation DNA Methylation Involved In Gamete Generation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process	Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Macromolecule Biosynthetic Process Cellular Aromatic Compound Metabolic Process Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Cell Differentiation Myeloid Cell Differentiation Cellular Metabolic Process Multicellular Organismal Development Regulation Of Cell Differentiation Hemopoiesis Developmental Process Immune System Development Myeloid Leukocyte Differentiation Immune System Process Regulation Of Immune System Process Regulation Of Chromosome Organization Anatomical Structure Development System Development Regulation Of Cellular Process
Tagcloud ?		cdc2 cdkn1b consequence crosstalk cyr61 decade description endometrial erb erk1 genomic implantation jund mimics peri picomolar pr progesterone progestin progestins r5020 represented repressors steroid stromal take uiii usf1 verified	alongside averaging bioinformatics conducting database degs downloaded encyclopedia enriched genomes glioblastoma gse4290 iongated kyoto ligandreceptor multichip neuroactive nontumor omnibus ontology raw sp1 subnets tf tfs transfac trimmed vesiclemediated zscores
Tagcloud (Difference) ?		cdc2 cdkn1b consequence crosstalk cyr61 decade description endometrial erb erk1 genomic implantation jund mimics peri picomolar pr progesterone progestin progestins r5020 represented repressors steroid stromal take uiii usf1 verified	alongside averaging bioinformatics conducting database degs downloaded encyclopedia enriched genomes glioblastoma gse4290 iongated kyoto ligandreceptor multichip neuroactive nontumor omnibus ontology raw sp1 subnets tf tfs transfac trimmed vesiclemediated zscores
Tagcloud (Intersection) ?