GFI1 and PIAS3

Number of citations of the paper that reports this interaction (PMID 11060035)
37

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		GFI1	PIAS3
Gene Name		growth factor independent 1 transcription repressor	protein inhibitor of activated STAT, 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nuclear Matrix Nuclear Body Transcriptional Repressor Complex	Nucleus Cytoplasm Dendrite Synapse
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Protein Binding Zinc Ion Binding Transcription Regulatory Region DNA Binding	Protein Binding Protein C-terminus Binding Zinc Ion Binding Potassium Channel Regulator Activity Ligase Activity SUMO Transferase Activity Enzyme Binding Protein N-terminus Binding
	Biological Process	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Mechanosensory Behavior Negative Regulation Of Cell Fate Specification Negative Regulation Of Calcidiol 1-monooxygenase Activity Negative Regulation Of Vitamin D Biosynthetic Process Negative Regulation Of Neuron Projection Development Viral Process Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Toll-like Receptor Signaling Pathway Inner Ear Morphogenesis Auditory Receptor Cell Differentiation Positive Regulation Of Cell Fate Specification Cell Fate Commitment Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Interleukin-6-mediated Signaling Pathway Cellular Response To Lipopolysaccharide	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Response To Hormone Positive Regulation Of Gene Expression Protein Sumoylation Positive Regulation Of Protein Sumoylation Positive Regulation Of Membrane Potential
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: PIAS2 PIAS3 PICK1 RUNX1T1 SPI1	49 interactors: AR ATF7IP C19orf60 CARHSP1 CBS CREM EP300 ESR1 ESR2 GEMIN4 GFI1 GLUL HABP4 HDAC1 HMGA2 MITF NCOA2 NR3C2 OPN1LW PGR PPP1CA PRPF40A PSMC1 RAC1 RELA SATB1 SERBP1 SERPINA10 SIAH1 SIAH2 SKIL SMAD2 SMAD3 SMAD4 SREBF2 STAT3 SUMO1 SUMO2 SUMO3 TBP TRIM27 TRIM32 TRIM55 TRIM63 UBA1 UBE2I ZFHX3 ZMIZ1 ZMIZ2
Entrez ID		2672	10401
HPRD ID		07527	09068
Ensembl ID		ENSG00000162676	ENSG00000131788
Uniprot IDs		B3KVN4 Q99684	B3KNI3 Q6IAR4 Q9Y6X2
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Peptidyl-lysine Modification Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process RNA Biosynthetic Process Peptidyl-amino Acid Modification Positive Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Gene Expression, Epigenetic Hypermethylation Of CpG Island Negative Regulation Of MHC Class II Biosynthetic Process RNA Metabolic Process DNA Methylation Involved In Embryo Development Cellular Protein Modification Process Apoptotic Process Involved In Patterning Of Blood Vessels Negative Regulation Of Histone H4 Acetylation Dendritic Spine Maintenance Positive Regulation Of Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Lymphoid Progenitor Cell Differentiation Neuronal Ion Channel Clustering Positive Regulation Of Gene Expression Macromolecule Biosynthetic Process Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Protein Sumoylation Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Actin Nucleation Regulation Of Metabolic Process Granulocyte Differentiation Regulation Of Histone H4 Acetylation Long Term Synaptic Depression Anatomical Structure Regression Positive Regulation Of Receptor Internalization Regulation Of Protein Sumoylation Macrophage Differentiation Regulation Of DNA Methylation Negative Regulation Of Histone Acetylation Regulation Of Androgen Receptor Signaling Pathway Regulation Of Arp2/3 Complex-mediated Actin Nucleation Dendritic Spine Organization Regulation Of Transcription, DNA-templated Negative Regulation Of Peptidyl-lysine Acetylation DNA Methylation Involved In Gamete Generation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process	Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Metabolic Process Gene Expression Transcription Initiation From RNA Polymerase II Promoter RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process DNA-templated Transcription, Initiation Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Cellular Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Response To Organic Substance Regulation Of Cellular Process Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Viral Process Cellular Response To Organic Substance Biosynthetic Process Epithelium Development Regulation Of Signal Transduction Regulation Of Cell Death Regulation Of Signaling Response To Stimulus Cellular Response To Stimulus
Tagcloud ?		cdc2 cdkn1b consequence crosstalk cyr61 decade description endometrial erb erk1 genomic implantation jund mimics peri picomolar pr progesterone progestin progestins r5020 represented repressors steroid stromal take uiii usf1 verified	achieved atm atr consistently crucial dbc1 deficient diverse establish etoposide finely genotoxic interaction knockdown metabolism modification modifier promoted promotion remarkably senp1 sirt1 sumo sumo1 sumo2 sumoylation switching transactivation ubiquitin
Tagcloud (Difference) ?		cdc2 cdkn1b consequence crosstalk cyr61 decade description endometrial erb erk1 genomic implantation jund mimics peri picomolar pr progesterone progestin progestins r5020 represented repressors steroid stromal take uiii usf1 verified	achieved atm atr consistently crucial dbc1 deficient diverse establish etoposide finely genotoxic interaction knockdown metabolism modification modifier promoted promotion remarkably senp1 sirt1 sumo sumo1 sumo2 sumoylation switching transactivation ubiquitin
Tagcloud (Intersection) ?