GFI1 and RUNX1T1

Number of citations of the paper that reports this interaction (PMID 12874834)
30

Data Source:
HPRD (in vitro, in vivo)

		GFI1	RUNX1T1
Gene Name		growth factor independent 1 transcription repressor	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nuclear Matrix Nuclear Body Transcriptional Repressor Complex	Nucleoplasm Cytoplasm Mitochondrion Nuclear Matrix
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Protein Binding Zinc Ion Binding Transcription Regulatory Region DNA Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Mechanosensory Behavior Negative Regulation Of Cell Fate Specification Negative Regulation Of Calcidiol 1-monooxygenase Activity Negative Regulation Of Vitamin D Biosynthetic Process Negative Regulation Of Neuron Projection Development Viral Process Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Toll-like Receptor Signaling Pathway Inner Ear Morphogenesis Auditory Receptor Cell Differentiation Positive Regulation Of Cell Fate Specification Cell Fate Commitment Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Interleukin-6-mediated Signaling Pathway Cellular Response To Lipopolysaccharide	Generation Of Precursor Metabolites And Energy Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: PIAS2 PIAS3 PICK1 RUNX1T1 SPI1	53 interactors: ABI3 ATN1 BCL6 BRCA1 C19orf57 CBFA2T3 CCDC36 CEP170P1 CPSF7 CREB3L1 DNMT1 EFHC2 EPS8 ETS1 GFI1 GSE1 HDAC1 HDAC3 HDAC8 HOMER3 HSP90AA1 ID1 ID3 KPNA1 KPNB1 LPXN LZTS2 MEOX2 MID2 NCOR1 NCOR2 NECAB2 NEUROG1 PCBD2 PRDM14 PRKAR2A SIN3A SPEN SPERT SPRY2 STX11 TAF9B TAL2 TCF12 TCF3 TCF4 TRIM42 UBQLN4 VDR WBP11 ZBTB16 ZMYM4 ZNF652
Entrez ID		2672	862
HPRD ID		07527	00590
Ensembl ID		ENSG00000162676	ENSG00000079102
Uniprot IDs		B3KVN4 Q99684	B2R6I9 Q06455
PDB IDs			1WQ6 2DJ8 2H7B 2KNH 2KYG 2OD1 2ODD 2PP4 4JOL
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Peptidyl-lysine Modification Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process RNA Biosynthetic Process Peptidyl-amino Acid Modification Positive Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Gene Expression, Epigenetic Hypermethylation Of CpG Island Negative Regulation Of MHC Class II Biosynthetic Process RNA Metabolic Process DNA Methylation Involved In Embryo Development Cellular Protein Modification Process Apoptotic Process Involved In Patterning Of Blood Vessels Negative Regulation Of Histone H4 Acetylation Dendritic Spine Maintenance Positive Regulation Of Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Lymphoid Progenitor Cell Differentiation Neuronal Ion Channel Clustering Positive Regulation Of Gene Expression Macromolecule Biosynthetic Process Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Protein Sumoylation Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Actin Nucleation Regulation Of Metabolic Process Granulocyte Differentiation Regulation Of Histone H4 Acetylation Long Term Synaptic Depression Anatomical Structure Regression Positive Regulation Of Receptor Internalization Regulation Of Protein Sumoylation Macrophage Differentiation Regulation Of DNA Methylation Negative Regulation Of Histone Acetylation Regulation Of Androgen Receptor Signaling Pathway Regulation Of Arp2/3 Complex-mediated Actin Nucleation Dendritic Spine Organization Regulation Of Transcription, DNA-templated Negative Regulation Of Peptidyl-lysine Acetylation DNA Methylation Involved In Gamete Generation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process	Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of RNA Biosynthetic Process RNA Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Heterocycle Metabolic Process Negative Regulation Of Gene Expression Cellular Aromatic Compound Metabolic Process Gene Expression Negative Regulation Of Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cellular Process Multicellular Organismal Development Positive Regulation Of Macromolecule Biosynthetic Process Response To Organic Substance Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Embryo Development Cellular Metabolic Process Organ Development Developmental Process Anatomical Structure Development System Development Transcription Initiation From RNA Polymerase II Promoter Regulation Of Cell Differentiation Cellular Response To Organic Substance Rhythmic Process Organelle Organization Regulation Of Apoptotic Process
Tagcloud ?		cdc2 cdkn1b consequence crosstalk cyr61 decade description endometrial erb erk1 genomic implantation jund mimics peri picomolar pr progesterone progestin progestins r5020 represented repressors steroid stromal take uiii usf1 verified	accumulated aml aml201 cbfb cebpa chimeric clarify comprehensively cooperative cytogenetically cytogenetics dnmt3a exclusive flt3 impacts japan kit leukemianet mll myh11 npm1 precise ptd recurrently registered sole stratified translocations
Tagcloud (Difference) ?		cdc2 cdkn1b consequence crosstalk cyr61 decade description endometrial erb erk1 genomic implantation jund mimics peri picomolar pr progesterone progestin progestins r5020 represented repressors steroid stromal take uiii usf1 verified	accumulated aml aml201 cbfb cebpa chimeric clarify comprehensively cooperative cytogenetically cytogenetics dnmt3a exclusive flt3 impacts japan kit leukemianet mll myh11 npm1 precise ptd recurrently registered sole stratified translocations
Tagcloud (Intersection) ?