AMFR and UBE2D4

Number of citations of the paper that reports this interaction (PubMedID 19549727)
29

Data Source:
BioGRID (two hybrid)

		AMFR	UBE2D4
Description		autocrine motility factor receptor	ubiquitin conjugating enzyme E2 D4
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Dendrite Growth Cone Protein-containing Complex Derlin-1 Retrotranslocation Complex Neuronal Cell Body Endoplasmic Reticulum Quality Control Compartment Perinuclear Region Of Cytoplasm	Nucleus
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Protein-macromolecule Adaptor Activity Ubiquitin-ubiquitin Ligase Activity Signaling Receptor Activity Identical Protein Binding Ubiquitin Binding Metal Ion Binding Protein-folding Chaperone Binding Ubiquitin Protein Ligase Activity BAT3 Complex Binding Ubiquitin-specific Protease Binding	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Signal Transduction Canonical NF-kappaB Signal Transduction Learning Or Memory Wnt Signaling Pathway Protein Ubiquitination Endoplasmic Reticulum Unfolded Protein Response ERAD Pathway Non-canonical NF-kappaB Signal Transduction Protein K27-linked Ubiquitination Protein Autoubiquitination Protein K48-linked Ubiquitination Negative Regulation Of Canonical Wnt Signaling Pathway Endoplasmic Reticulum Mannose Trimming Regulation Of SREBP Signaling Pathway	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein K29-linked Ubiquitination Protein K27-linked Ubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination
Pathways		N-glycan trimming in the ER and Calnexin/Calreticulin cycle ER Quality Control Compartment (ERQC)	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Breast cancer ( 29059683)
Interacting Genes		32 interacting genes: BAG6 CRMP1 CYP2E1 DERL1 DHFR GPI HERPUD1 HTT KPNB1 MGRN1 PPP1R13L RETREG1 SOD1 TAB3 TMCO1 TOM1L1 TRIM25 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2G1 UBE2G2 UBE2K UBE2N UBE2T UBE2W UBL4A UFD1 USP13 VCP	111 interacting genes: AMFR ARIH2 ARK2C BFAR BIRC8 CADPS2 CHFR CNOT4 DAZAP2 DTX1 DTX2 DTX3 DTX3L DZIP3 IKBKG INCA1 ITCH LNX1 LRSAM1 MAGEA11 MAP3K1 MARCHF3 MDM2 MGRN1 MIB1 MID1 MID2 MKRN1 MKRN2 MKRN3 MUL1 MYBL2 MYLIP OTUB1 PHF7 PJA2 POLR2E PRKN RBCK1 RBX1 RCHY1 REL RFWD3 RING1 RLIM RMND5B RNF103 RNF11 RNF111 RNF114 RNF115 RNF125 RNF126 RNF13 RNF130 RNF138 RNF14 RNF150 RNF166 RNF167 RNF181 RNF185 RNF2 RNF216 RNF25 RNF26 RNF31 RNF38 RNF4 RNF43 RNF5 RNF7 SIAH1 STUB1 TOPORS TRAF6 TRAF7 TRIM10 TRIM17 TRIM2 TRIM23 TRIM25 TRIM27 TRIM3 TRIM31 TRIM35 TRIM38 TRIM39 TRIM43 TRIM45 TRIM5 TRIM50 TRIM54 TRIM62 TRIM8 UBA1 UBA6 UBC UBE4A UBOX5 UBR5 UBTD1 UBTD2 UFM1 UHRF2 UVSSA WWP2 XIAP ZNRF1 ZNRF2 ZNRF4
Entrez ID		267	51619
HPRD ID		09130	14242
Ensembl ID		ENSG00000159461	ENSG00000078967
Uniprot IDs		Q9UKV5	Q9Y2X8
PDB IDs		2EJS 2LVN 2LVO 2LVP 2LVQ 2LXH 2LXP 3FSH 3H8K 3TIW 4G3O 4LAD 8T0S
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Catabolic Process Ubiquitin-protein Transferase Activity Proteolysis Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Ubiquitination Ubiquitin Protein Ligase Binding Post-translational Protein Modification Protein Modification By Small Protein Conjugation Proteasomal Protein Catabolic Process ERAD Pathway Protein Monoubiquitination Protein Catabolic Process Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Misfolded Protein Protein Metabolic Process Response To Misfolded Protein Response To Endoplasmic Reticulum Stress Retrograde Protein Transport, ER To Cytosol Cytosol Cellular Response To Stress Cellular Response To Topologically Incorrect Protein Macromolecule Metabolic Process Protein Exit From Endoplasmic Reticulum Protein K11-linked Ubiquitination Regulation Of Proteasomal Protein Catabolic Process Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Positive Regulation Of ERAD Pathway Ubiquitin-like Protein Transferase Activity Ubiquitin-specific Protease Binding ATP Binding Negative Regulation Of Signal Transduction BAT3 Complex Transferase Activity Protein K63-linked Ubiquitination Regulation Of ERAD Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein K6-linked Ubiquitination Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process BAT3 Complex Binding Maintenance Of Unfolded Protein Regulation Of Ubiquitin-dependent Protein Catabolic Process	Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Zinc Ion Binding Protein Polyubiquitination Transferase Activity Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Metal Ion Binding Macromolecule Catabolic Process Proteolysis Macromolecule Metabolic Process Catabolic Process Protein Autoubiquitination Protein K48-linked Ubiquitination Proteasomal Protein Catabolic Process Protein K63-linked Ubiquitination Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Ligase Complex Cytoplasm Ubiquitin-ubiquitin Ligase Activity Innate Immune Response Response To Stress Defense Response To Symbiont Response To Other Organism Defense Response To Other Organism Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Protein K29-linked Ubiquitination Regulation Of Signal Transduction Response To External Biotic Stimulus Immune System Process Defense Response Suppression Of Viral Release By Host Regulation Of Intracellular Signal Transduction Immune Response Protein Monoubiquitination Regulation Of Defense Response Cellular Response To Stress Positive Regulation Of Catabolic Process Positive Regulation Of Signal Transduction Canonical NF-kappaB Signal Transduction Protein Destabilization Host-mediated Suppression Of Symbiont Invasion
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