AMFR and TMCO1

Number of citations of the paper that reports this interaction (PubMedID 35121659)
61

Data Source:
BioGRID (pull down, pull down)

		AMFR	TMCO1
Description		autocrine motility factor receptor	transmembrane and coiled-coil domains 1
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Dendrite Growth Cone Protein-containing Complex Derlin-1 Retrotranslocation Complex Neuronal Cell Body Endoplasmic Reticulum Quality Control Compartment Perinuclear Region Of Cytoplasm	Golgi Membrane Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Mitochondrial Membrane Multi-pass Translocon Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Protein-macromolecule Adaptor Activity Ubiquitin-ubiquitin Ligase Activity Signaling Receptor Activity Identical Protein Binding Ubiquitin Binding Metal Ion Binding Protein-folding Chaperone Binding Ubiquitin Protein Ligase Activity BAT3 Complex Binding Ubiquitin-specific Protease Binding	Calcium Channel Activity Protein Binding Ribosome Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Signal Transduction Canonical NF-kappaB Signal Transduction Learning Or Memory Wnt Signaling Pathway Protein Ubiquitination Endoplasmic Reticulum Unfolded Protein Response ERAD Pathway Non-canonical NF-kappaB Signal Transduction Protein K27-linked Ubiquitination Protein Autoubiquitination Protein K48-linked Ubiquitination Negative Regulation Of Canonical Wnt Signaling Pathway Endoplasmic Reticulum Mannose Trimming Regulation Of SREBP Signaling Pathway	Ossification Monoatomic Ion Transport Calcium Ion Transport ER Overload Response Endoplasmic Reticulum Calcium Ion Homeostasis Monoatomic Ion Transmembrane Transport Calcium Ion Transmembrane Transport Multi-pass Transmembrane Protein Insertion Into ER Membrane
Pathways		N-glycan trimming in the ER and Calnexin/Calreticulin cycle ER Quality Control Compartment (ERQC)
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Breast cancer ( 29059683)	Glaucoma ( 31959993 21532571 30054594) Glaucoma (high intraocular pressure) ( 33627673) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 33627673 25173105 29891935) Intraocular pressure ( 30054594 31959993 31798171 29785010 29617998 29235454 28073927 25173106 24002674 22570627) Intraocular pressure (corneal compensated) ( 30894546) Medication use (antiglaucoma preparations and miotics) ( 31015401) Refractive error ( 32231278) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993)
Interacting Genes		32 interacting genes: BAG6 CRMP1 CYP2E1 DERL1 DHFR GPI HERPUD1 HTT KPNB1 MGRN1 PPP1R13L RETREG1 SOD1 TAB3 TMCO1 TOM1L1 TRIM25 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2G1 UBE2G2 UBE2K UBE2N UBE2T UBE2W UBL4A UFD1 USP13 VCP	1 interacting genes: AMFR
Entrez ID		267	54499
HPRD ID		09130	14243
Ensembl ID		ENSG00000159461	ENSG00000143183
Uniprot IDs		Q9UKV5	B7Z591 Q9UM00
PDB IDs		2EJS 2LVN 2LVO 2LVP 2LVQ 2LXH 2LXP 3FSH 3H8K 3TIW 4G3O 4LAD 8T0S	6W6L
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Catabolic Process Ubiquitin-protein Transferase Activity Proteolysis Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Ubiquitination Ubiquitin Protein Ligase Binding Post-translational Protein Modification Protein Modification By Small Protein Conjugation Proteasomal Protein Catabolic Process ERAD Pathway Protein Monoubiquitination Protein Catabolic Process Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Misfolded Protein Protein Metabolic Process Response To Misfolded Protein Response To Endoplasmic Reticulum Stress Retrograde Protein Transport, ER To Cytosol Cytosol Cellular Response To Stress Cellular Response To Topologically Incorrect Protein Macromolecule Metabolic Process Protein Exit From Endoplasmic Reticulum Protein K11-linked Ubiquitination Regulation Of Proteasomal Protein Catabolic Process Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Positive Regulation Of ERAD Pathway Ubiquitin-like Protein Transferase Activity Ubiquitin-specific Protease Binding ATP Binding Negative Regulation Of Signal Transduction BAT3 Complex Transferase Activity Protein K63-linked Ubiquitination Regulation Of ERAD Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein K6-linked Ubiquitination Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process BAT3 Complex Binding Maintenance Of Unfolded Protein Regulation Of Ubiquitin-dependent Protein Catabolic Process	Regulation Of SREBP Signaling Pathway Protein Alpha-1,2-demannosylation Ubiquitin-ubiquitin Ligase Activity Endoplasmic Reticulum Mannose Trimming Protein K27-linked Ubiquitination BAT3 Complex Binding Derlin-1 Retrotranslocation Complex Acute Inflammatory Response To Antigenic Stimulus Antibody-dependent Cellular Cytotoxicity IgG Receptor Activity Hypersensitivity IgG Binding Ubiquitin-specific Protease Binding Protein Deglycosylation Endoplasmic Reticulum Quality Control Compartment Non-canonical NF-kappaB Signal Transduction Fc-gamma Receptor Signaling Pathway Inflammatory Response To Antigenic Stimulus Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Fc Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction Acute Inflammatory Response Endoplasmic Reticulum Unfolded Protein Response Protein Autoubiquitination Positive Regulation Of Phagocytosis Leukocyte Mediated Cytotoxicity
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