AMFR and CYP2E1

Number of citations of the paper that reports this interaction (PubMedID 21209460)
103

Data Source:
BioGRID (enzymatic study)

		AMFR	CYP2E1
Description		autocrine motility factor receptor	cytochrome P450 family 2 subfamily E member 1
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Dendrite Growth Cone Protein-containing Complex Derlin-1 Retrotranslocation Complex Neuronal Cell Body Endoplasmic Reticulum Quality Control Compartment Perinuclear Region Of Cytoplasm	Cytoplasm Mitochondrion Mitochondrial Inner Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Protein-macromolecule Adaptor Activity Ubiquitin-ubiquitin Ligase Activity Signaling Receptor Activity Identical Protein Binding Ubiquitin Binding Metal Ion Binding Protein-folding Chaperone Binding Ubiquitin Protein Ligase Activity BAT3 Complex Binding Ubiquitin-specific Protease Binding	Monooxygenase Activity Iron Ion Binding Arachidonate Epoxygenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen 4-nitrophenol 2-monooxygenase Activity Oxygen Binding Enzyme Binding Heme Binding Hsp70 Protein Binding Metal Ion Binding Hsp90 Protein Binding Long-chain Fatty Acid Omega-1 Hydroxylase Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Signal Transduction Canonical NF-kappaB Signal Transduction Learning Or Memory Wnt Signaling Pathway Protein Ubiquitination Endoplasmic Reticulum Unfolded Protein Response ERAD Pathway Non-canonical NF-kappaB Signal Transduction Protein K27-linked Ubiquitination Protein Autoubiquitination Protein K48-linked Ubiquitination Negative Regulation Of Canonical Wnt Signaling Pathway Endoplasmic Reticulum Mannose Trimming Regulation Of SREBP Signaling Pathway	Long-chain Fatty Acid Metabolic Process Lipid Hydroxylation Lipid Metabolic Process Fatty Acid Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Response To Bacterium Monoterpenoid Metabolic Process Carbon Tetrachloride Metabolic Process Benzene Metabolic Process 4-nitrophenol Metabolic Process Epoxygenase P450 Pathway Halogenated Hydrocarbon Metabolic Process Long-chain Fatty Acid Biosynthetic Process
Pathways		N-glycan trimming in the ER and Calnexin/Calreticulin cycle ER Quality Control Compartment (ERQC)	Xenobiotics CYP2E1 reactions Biosynthesis of maresin-like SPMs Aspirin ADME Paracetamol ADME
Drugs			Diacerein
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Breast cancer ( 29059683)	Childhood body mass index ( 31752434) Coffee consumption ( 31046077) Gout ( 22179738) Obesity-related traits ( 23251661) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes		32 interacting genes: BAG6 CRMP1 CYP2E1 DERL1 DHFR GPI HERPUD1 HTT KPNB1 MGRN1 PPP1R13L RETREG1 SOD1 TAB3 TMCO1 TOM1L1 TRIM25 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2G1 UBE2G2 UBE2K UBE2N UBE2T UBE2W UBL4A UFD1 USP13 VCP	15 interacting genes: ABCA5 AGXT2 AMFR CLU CYB5A ECHS1 FANCG GATM LAMC3 MAFG NMI POR PTN RPL13A STUB1
Entrez ID		267	1571
HPRD ID		09130	11813
Ensembl ID		ENSG00000159461	ENSG00000130649
Uniprot IDs		Q9UKV5	P05181
PDB IDs		2EJS 2LVN 2LVO 2LVP 2LVQ 2LXH 2LXP 3FSH 3H8K 3TIW 4G3O 4LAD 8T0S	3E4E 3E6I 3GPH 3KOH 3LC4 3T3Z
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Catabolic Process Ubiquitin-protein Transferase Activity Proteolysis Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Ubiquitination Ubiquitin Protein Ligase Binding Post-translational Protein Modification Protein Modification By Small Protein Conjugation Proteasomal Protein Catabolic Process ERAD Pathway Protein Monoubiquitination Protein Catabolic Process Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Misfolded Protein Protein Metabolic Process Response To Misfolded Protein Response To Endoplasmic Reticulum Stress Retrograde Protein Transport, ER To Cytosol Cytosol Cellular Response To Stress Cellular Response To Topologically Incorrect Protein Macromolecule Metabolic Process Protein Exit From Endoplasmic Reticulum Protein K11-linked Ubiquitination Regulation Of Proteasomal Protein Catabolic Process Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Positive Regulation Of ERAD Pathway Ubiquitin-like Protein Transferase Activity Ubiquitin-specific Protease Binding ATP Binding Negative Regulation Of Signal Transduction BAT3 Complex Transferase Activity Protein K63-linked Ubiquitination Regulation Of ERAD Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein K6-linked Ubiquitination Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process BAT3 Complex Binding Maintenance Of Unfolded Protein Regulation Of Ubiquitin-dependent Protein Catabolic Process	Protein-folding Chaperone Binding Ubiquitin-ubiquitin Ligase Activity Response To Misfolded Protein Reverse Cholesterol Transport Misfolded Protein Binding Intracellular Membrane-bounded Organelle Perinuclear Endoplasmic Reticulum Lumen Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Tau Protein Binding Regulation Of Neuronal Signal Transduction Monocarboxylic Acid Metabolic Process 3-hydroxypropionyl-CoA Dehydratase Activity Modified Amino Acid Metabolic Process Glycine Amidinotransferase Activity Amidinotransferase Activity Iron-cytochrome-c Reductase Activity Positive Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Nitric Oxide Dioxygenase NAD(P)H Activity Regulation Of Hormone Metabolic Process Nitrate Catabolic Process Positive Regulation Of Chaperone-mediated Protein Complex Assembly Negative Regulation Of Formation Of Translation Preinitiation Complex Beta-alanine:pyruvate Transaminase Activity N(omega),N(omega)-dimethyl-L-arginine Catabolic Process (R)-3-amino-2-methylpropionate-pyruvate Transaminase Activity L-alanine Catabolic Process, By Transamination Regulation Of Cellular Response To Stress Protein Polyubiquitination Endoplasmic Reticulum Learning Or Memory Endoplasmic Reticulum Unfolded Protein Response Protein Autoubiquitination Regulation Of Multicellular Organismal Process Cholesterol Transport Mitochondrion Macrophage Activation Positive Regulation Of Neurofibrillary Tangle Assembly Regulation Of Nitric Oxide Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process Crotonyl-CoA Hydratase Activity Creatine Biosynthetic Process Nitric Oxide Catabolic Process Organofluorine Metabolic Process Dendrite Regeneration Positive Regulation Of Reverse Cholesterol Transport Negative Regulation Of Cytoplasmic Translational Initiation Glycine Biosynthetic Process, By Transamination Of Glyoxylate Regulation Of Cell Population Proliferation Cognition
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