AMFR and TAB3

Number of citations of the paper that reports this interaction (PubMedID 36593296)
0

Data Source:
BioGRID (imaging technique, enzymatic study)

		AMFR	TAB3
Description		autocrine motility factor receptor	TGF-beta activated kinase 1 (MAP3K7) binding protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Dendrite Growth Cone Protein-containing Complex Derlin-1 Retrotranslocation Complex Neuronal Cell Body Endoplasmic Reticulum Quality Control Compartment Perinuclear Region Of Cytoplasm	Endoplasmic Reticulum Cytosol Plasma Membrane Endosome Membrane Extracellular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Protein-macromolecule Adaptor Activity Ubiquitin-ubiquitin Ligase Activity Signaling Receptor Activity Identical Protein Binding Ubiquitin Binding Metal Ion Binding Protein-folding Chaperone Binding Ubiquitin Protein Ligase Activity BAT3 Complex Binding Ubiquitin-specific Protease Binding	Protein Binding Zinc Ion Binding Ubiquitin Binding Metal Ion Binding Molecular Adaptor Activity K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Signal Transduction Canonical NF-kappaB Signal Transduction Learning Or Memory Wnt Signaling Pathway Protein Ubiquitination Endoplasmic Reticulum Unfolded Protein Response ERAD Pathway Non-canonical NF-kappaB Signal Transduction Protein K27-linked Ubiquitination Protein Autoubiquitination Protein K48-linked Ubiquitination Negative Regulation Of Canonical Wnt Signaling Pathway Endoplasmic Reticulum Mannose Trimming Regulation Of SREBP Signaling Pathway	Canonical NF-kappaB Signal Transduction Response To Bacterium Negative Regulation Of Autophagy Non-canonical NF-kappaB Signal Transduction P38MAPK Cascade Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction
Pathways		N-glycan trimming in the ER and Calnexin/Calreticulin cycle ER Quality Control Compartment (ERQC)	NOD1/2 Signaling Pathway FCERI mediated NF-kB activation TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 TNFR1-induced NF-kappa-B signaling pathway CLEC7A (Dectin-1) signaling TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway SARS-CoV-2 activates/modulates innate and adaptive immune responses IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Breast cancer ( 29059683)
Interacting Genes		32 interacting genes: BAG6 CRMP1 CYP2E1 DERL1 DHFR GPI HERPUD1 HTT KPNB1 MGRN1 PPP1R13L RETREG1 SOD1 TAB3 TMCO1 TOM1L1 TRIM25 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2G1 UBE2G2 UBE2K UBE2N UBE2T UBE2W UBL4A UFD1 USP13 VCP	12 interacting genes: AMFR CEP57L1 IKBKG MAP3K7CL OGT PIN1 PPIL3 STAT3 TAB1 TRAF2 TRAF6 UBC
Entrez ID		267	257397
HPRD ID		09130	06738
Ensembl ID		ENSG00000159461	ENSG00000157625
Uniprot IDs		Q9UKV5	Q8N5C8
PDB IDs		2EJS 2LVN 2LVO 2LVP 2LVQ 2LXH 2LXP 3FSH 3H8K 3TIW 4G3O 4LAD 8T0S
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Catabolic Process Ubiquitin-protein Transferase Activity Proteolysis Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Ubiquitination Ubiquitin Protein Ligase Binding Post-translational Protein Modification Protein Modification By Small Protein Conjugation Proteasomal Protein Catabolic Process ERAD Pathway Protein Monoubiquitination Protein Catabolic Process Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Misfolded Protein Protein Metabolic Process Response To Misfolded Protein Response To Endoplasmic Reticulum Stress Retrograde Protein Transport, ER To Cytosol Cytosol Cellular Response To Stress Cellular Response To Topologically Incorrect Protein Macromolecule Metabolic Process Protein Exit From Endoplasmic Reticulum Protein K11-linked Ubiquitination Regulation Of Proteasomal Protein Catabolic Process Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Positive Regulation Of ERAD Pathway Ubiquitin-like Protein Transferase Activity Ubiquitin-specific Protease Binding ATP Binding Negative Regulation Of Signal Transduction BAT3 Complex Transferase Activity Protein K63-linked Ubiquitination Regulation Of ERAD Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein K6-linked Ubiquitination Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process BAT3 Complex Binding Maintenance Of Unfolded Protein Regulation Of Ubiquitin-dependent Protein Catabolic Process	Canonical NF-kappaB Signal Transduction Non-canonical NF-kappaB Signal Transduction Protein-containing Complex Signaling Adaptor Activity Intracellular Signaling Cassette Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Protein Autoubiquitination Positive Regulation Of Canonical NF-kappaB Signal Transduction CD40 Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-17-mediated Signaling Pathway Regulation Of Phosphorus Metabolic Process CD40 Receptor Complex Positive Regulation Of Signal Transduction Positive Regulation Of JUN Kinase Activity Ubiquitin Ligase Complex Ubiquitin-ubiquitin Ligase Activity Positive Regulation Of Phosphate Metabolic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Gene Expression Negative Regulation Of Catabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Localization To Synapse Negative Regulation Of Signal Transduction Positive Regulation Of T Cell Cytokine Production Regulation Of Receptor Localization To Synapse Tumor Necrosis Factor Receptor Binding Regulation Of Signal Transduction Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Cell Communication Negative Regulation Of Signaling Peptidyl-prolyl Cis-trans Isomerase Activity Positive Regulation Of MAP Kinase Activity Cytosol Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Cytokine Production Positive Regulation Of Interleukin-2 Production Regulation Of T Cell Cytokine Production Protein Modification Process Protein-macromolecule Adaptor Activity Glutamatergic Synapse Intracellular Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation
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