AMFR and GPI

Number of citations of the paper that reports this interaction (PubMedID 16563432)
0

Data Source:
HPRD (in vitro)

		AMFR	GPI
Description		autocrine motility factor receptor	glucose-6-phosphate isomerase
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Dendrite Growth Cone Protein-containing Complex Derlin-1 Retrotranslocation Complex Neuronal Cell Body Endoplasmic Reticulum Quality Control Compartment Perinuclear Region Of Cytoplasm	Extracellular Region Extracellular Space Cytoplasm Cytosol Plasma Membrane Membrane Secretory Granule Lumen Ciliary Membrane Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Protein-macromolecule Adaptor Activity Ubiquitin-ubiquitin Ligase Activity Signaling Receptor Activity Identical Protein Binding Ubiquitin Binding Metal Ion Binding Protein-folding Chaperone Binding Ubiquitin Protein Ligase Activity BAT3 Complex Binding Ubiquitin-specific Protease Binding	Glucose-6-phosphate Isomerase Activity Cytokine Activity Protein Binding Growth Factor Activity Isomerase Activity Ubiquitin Protein Ligase Binding Monosaccharide Binding Carbohydrate Derivative Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Signal Transduction Canonical NF-kappaB Signal Transduction Learning Or Memory Wnt Signaling Pathway Protein Ubiquitination Endoplasmic Reticulum Unfolded Protein Response ERAD Pathway Non-canonical NF-kappaB Signal Transduction Protein K27-linked Ubiquitination Protein Autoubiquitination Protein K48-linked Ubiquitination Negative Regulation Of Canonical Wnt Signaling Pathway Endoplasmic Reticulum Mannose Trimming Regulation Of SREBP Signaling Pathway	In Utero Embryonic Development Mesoderm Formation Positive Regulation Of Immunoglobulin Production Carbohydrate Metabolic Process Fructose 6-phosphate Metabolic Process Gluconeogenesis Glycolytic Process Humoral Immune Response Signal Transduction Hemostasis Learning Or Memory Positive Regulation Of Endothelial Cell Migration Response To Estradiol Response To Progesterone Response To Testosterone Erythrocyte Homeostasis Response To Immobilization Stress Response To Muscle Stretch Glucose Homeostasis Negative Regulation Of Apoptotic Process Response To Cadmium Ion Glucose 6-phosphate Metabolic Process Canonical Glycolysis Carbohydrate Derivative Metabolic Process
Pathways		N-glycan trimming in the ER and Calnexin/Calreticulin cycle ER Quality Control Compartment (ERQC)	TP53 Regulates Metabolic Genes Neutrophil degranulation Glycolysis Gluconeogenesis
Drugs			alpha-D-glucose 6-phosphate 6-phospho-D-gluconic acid 5-phospho-D-arabinohydroxamic acid D-glucitol 6-phosphate 5-Phosphoarabinonic Acid Glucose-6-Phosphate D-erythrose 4-phosphate Fructose-6-phosphate Copper Artenimol
Diseases			Anemia due to disorders of glycolytic enzymes, including: Hexokinase (HK) deficiency; Phosphoglycerate kinase 1 (PGK1) deficiency; Triose-phosphate isomerase (TPI) deficiency; Glucose phosphate isomerase (GPI) deficiency; Bisphosphoglycerate mutase (BPGM) deficiency
GWAS		Apolipoprotein A1 levels ( 32203549) Breast cancer ( 29059683)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Mean corpuscular volume ( 32888494)
Interacting Genes		32 interacting genes: BAG6 CRMP1 CYP2E1 DERL1 DHFR GPI HERPUD1 HTT KPNB1 MGRN1 PPP1R13L RETREG1 SOD1 TAB3 TMCO1 TOM1L1 TRIM25 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2G1 UBE2G2 UBE2K UBE2N UBE2T UBE2W UBL4A UFD1 USP13 VCP	6 interacting genes: AMFR CSNK2A1 IGFBP3 LINC01554 PARP14 PCNA
Entrez ID		267	2821
HPRD ID		09130	01394
Ensembl ID		ENSG00000159461	ENSG00000105220
Uniprot IDs		Q9UKV5	A0A2U3TZU2 B4DE36 P06744
PDB IDs		2EJS 2LVN 2LVO 2LVP 2LVQ 2LXH 2LXP 3FSH 3H8K 3TIW 4G3O 4LAD 8T0S	1IAT 1IRI 1JIQ 1JLH 1NUH 6XUH 6XUI 8BBH 8P2K 9FCW 9FHF 9FKC 9FKF
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Catabolic Process Ubiquitin-protein Transferase Activity Proteolysis Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Ubiquitination Ubiquitin Protein Ligase Binding Post-translational Protein Modification Protein Modification By Small Protein Conjugation Proteasomal Protein Catabolic Process ERAD Pathway Protein Monoubiquitination Protein Catabolic Process Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Misfolded Protein Protein Metabolic Process Response To Misfolded Protein Response To Endoplasmic Reticulum Stress Retrograde Protein Transport, ER To Cytosol Cytosol Cellular Response To Stress Cellular Response To Topologically Incorrect Protein Macromolecule Metabolic Process Protein Exit From Endoplasmic Reticulum Protein K11-linked Ubiquitination Regulation Of Proteasomal Protein Catabolic Process Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Positive Regulation Of ERAD Pathway Ubiquitin-like Protein Transferase Activity Ubiquitin-specific Protease Binding ATP Binding Negative Regulation Of Signal Transduction BAT3 Complex Transferase Activity Protein K63-linked Ubiquitination Regulation Of ERAD Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein K6-linked Ubiquitination Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process BAT3 Complex Binding Maintenance Of Unfolded Protein Regulation Of Ubiquitin-dependent Protein Catabolic Process	Negative Regulation Of Signal Transduction Regulation Of Cellular Response To Stress BAT3 Complex Binding Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Cell Growth Regulation Of Growth Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Protein Metabolic Process Dorsal/ventral Axon Guidance Spinal Cord Ventral Commissure Morphogenesis Negative Regulation Of Protein Phosphorylation Insulin-like Growth Factor Binding Protein Complex Protein Tyrosine Phosphatase Activator Activity Insulin-like Growth Factor Ternary Complex Negative Regulation Of Phosphorylation PCNA Complex Positive Regulation Of Deoxyribonuclease Activity PCNA-p21 Complex Replisome DNA Polymerase Processivity Factor Activity Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding Leading Strand Elongation Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Positive Regulation Of Interleukin-4-mediated Signaling Pathway Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Phosphate Metabolic Process Positive Regulation Of Aggrephagy Anterior/posterior Axon Guidance Negative Regulation Of Dendrite Development MutLalpha Complex Binding Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of Type II Interferon-mediated Signaling Pathway Derlin-1 Retrotranslocation Complex Insulin-like Growth Factor II Binding Regulation Of DNA Repair Positive Regulation Of DNA-directed DNA Polymerase Activity Regulation Of SREBP Signaling Pathway Wnt Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Cell Death Double-strand Break Repair Via Classical Nonhomologous End Joining Apoptotic Process Rhythmic Process Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Programmed Cell Death Negative Regulation Of Collateral Sprouting
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