AMFR and PPP1R13L

Number of citations of the paper that reports this interaction (PubMedID 35121659)
61

Data Source:
BioGRID (pull down)

		AMFR	PPP1R13L
Description		autocrine motility factor receptor	protein phosphatase 1 regulatory subunit 13 like
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Dendrite Growth Cone Protein-containing Complex Derlin-1 Retrotranslocation Complex Neuronal Cell Body Endoplasmic Reticulum Quality Control Compartment Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol Cell Junction Intercellular Bridge
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Protein-macromolecule Adaptor Activity Ubiquitin-ubiquitin Ligase Activity Signaling Receptor Activity Identical Protein Binding Ubiquitin Binding Metal Ion Binding Protein-folding Chaperone Binding Ubiquitin Protein Ligase Activity BAT3 Complex Binding Ubiquitin-specific Protease Binding	Transcription Corepressor Activity Protein Binding Identical Protein Binding Cadherin Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Signal Transduction Canonical NF-kappaB Signal Transduction Learning Or Memory Wnt Signaling Pathway Protein Ubiquitination Endoplasmic Reticulum Unfolded Protein Response ERAD Pathway Non-canonical NF-kappaB Signal Transduction Protein K27-linked Ubiquitination Protein Autoubiquitination Protein K48-linked Ubiquitination Negative Regulation Of Canonical Wnt Signaling Pathway Endoplasmic Reticulum Mannose Trimming Regulation Of SREBP Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Cardiac Right Ventricle Morphogenesis Ventricular Cardiac Muscle Tissue Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Post-embryonic Development Embryonic Camera-type Eye Development Multicellular Organism Growth Hair Cycle Positive Regulation Of Cell Differentiation Multicellular Organismal-level Homeostasis Negative Regulation Of Inflammatory Response Cardiac Muscle Contraction
Pathways		N-glycan trimming in the ER and Calnexin/Calreticulin cycle ER Quality Control Compartment (ERQC)	Regulation of TP53 Activity through Association with Co-factors
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Breast cancer ( 29059683)	Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465) Platelet count ( 32888494)
Interacting Genes		32 interacting genes: BAG6 CRMP1 CYP2E1 DERL1 DHFR GPI HERPUD1 HTT KPNB1 MGRN1 PPP1R13L RETREG1 SOD1 TAB3 TMCO1 TOM1L1 TRIM25 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2G1 UBE2G2 UBE2K UBE2N UBE2T UBE2W UBL4A UFD1 USP13 VCP	9 interacting genes: AMFR HIF1A PPP1CA RELA SHANK3 SP1 SRPK2 TP53 VHL
Entrez ID		267	10848
HPRD ID		09130	09195
Ensembl ID		ENSG00000159461	ENSG00000104881
Uniprot IDs		Q9UKV5	Q8WUF5
PDB IDs		2EJS 2LVN 2LVO 2LVP 2LVQ 2LXH 2LXP 3FSH 3H8K 3TIW 4G3O 4LAD 8T0S	2VGE 6DCX 6HL6 6RZ3 9GFO
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Catabolic Process Ubiquitin-protein Transferase Activity Proteolysis Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Ubiquitination Ubiquitin Protein Ligase Binding Post-translational Protein Modification Protein Modification By Small Protein Conjugation Proteasomal Protein Catabolic Process ERAD Pathway Protein Monoubiquitination Protein Catabolic Process Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Misfolded Protein Protein Metabolic Process Response To Misfolded Protein Response To Endoplasmic Reticulum Stress Retrograde Protein Transport, ER To Cytosol Cytosol Cellular Response To Stress Cellular Response To Topologically Incorrect Protein Macromolecule Metabolic Process Protein Exit From Endoplasmic Reticulum Protein K11-linked Ubiquitination Regulation Of Proteasomal Protein Catabolic Process Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Positive Regulation Of ERAD Pathway Ubiquitin-like Protein Transferase Activity Ubiquitin-specific Protease Binding ATP Binding Negative Regulation Of Signal Transduction BAT3 Complex Transferase Activity Protein K63-linked Ubiquitination Regulation Of ERAD Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein K6-linked Ubiquitination Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process BAT3 Complex Binding Maintenance Of Unfolded Protein Regulation Of Ubiquitin-dependent Protein Catabolic Process	Regulation Of Apoptotic Process Histone Deacetylase Binding Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway Cellular Response To Stress Transcription Coactivator Binding Positive Regulation Of MiRNA Transcription Regulation Of Carbohydrate Catabolic Process Positive Regulation Of MiRNA Metabolic Process Regulation Of Signal Transduction Regulation Of MiRNA Transcription Regulation Of Amide Metabolic Process Response To Stress Regulation Of MiRNA Metabolic Process Response To Light Stimulus General Transcription Initiation Factor Binding Regulation Of Cell Communication Regulation Of Signaling Regulation Of Thymocyte Apoptotic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Neurogenesis Response To Oxidative Stress Anatomical Structure Morphogenesis Intracellular Signaling Cassette Enzyme Binding Lactate Metabolic Process Cellular Response To Decreased Oxygen Levels Cellular Response To Hypoxia Positive Regulation Of Signal Transduction Regulation Of Generation Of Precursor Metabolites And Energy DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Nervous System Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Amyloid-beta Formation Response To Radiation Regulation Of Cell Population Proliferation Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Biosynthetic Process Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Transcription Elongation By RNA Polymerase II Cellular Response To Oxygen Levels Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of MiRNA Transcription Positive Regulation Of RNA Metabolic Process
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