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PTPN23 and LRRK2
Number of citations of the paper that reports this interaction (PMID
19001729
)
2
Data Source:
BioGRID
(two hybrid)
PTPN23
LRRK2
Gene Name
protein tyrosine phosphatase, non-receptor type 23
leucine-rich repeat kinase 2
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Early Endosome
Cytoplasmic Membrane-bounded Vesicle
Ciliary Basal Body
Extracellular Vesicular Exosome
Extracellular Space
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Mitochondrial Inner Membrane
Mitochondrial Matrix
Lysosome
Endosome
Endoplasmic Reticulum
Golgi Apparatus
Trans-Golgi Network
Cytosol
Plasma Membrane
Synaptic Vesicle
Inclusion Body
Axon
Dendrite
Cytoplasmic Vesicle
Mitochondrial Membrane
Cytoplasmic Side Of Mitochondrial Outer Membrane
Dendrite Cytoplasm
Neuron Projection
Neuronal Cell Body
Terminal Bouton
Perikaryon
Membrane Raft
Extracellular Vesicular Exosome
Molecular Function
Protein Tyrosine Phosphatase Activity
Protein Binding
Protein Kinase Binding
SNARE Binding
Glycoprotein Binding
Actin Binding
GTPase Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Activity
GTPase Activator Activity
Protein Binding
ATP Binding
GTP Binding
Tubulin Binding
Kinase Activity
Rho GTPase Binding
Syntaxin-1 Binding
Clathrin Binding
GTP-dependent Protein Kinase Activity
Peroxidase Inhibitor Activity
Identical Protein Binding
Protein Homodimerization Activity
Ion Channel Binding
Protein Kinase A Binding
Biological Process
Negative Regulation Of Epithelial Cell Migration
Protein Transport
Peptidyl-tyrosine Dephosphorylation
Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Cilium Morphogenesis
Positive Regulation Of Homophilic Cell Adhesion
Positive Regulation Of Adherens Junction Organization
Positive Regulation Of Early Endosome To Late Endosome Transport
MAPK Cascade
Activation Of MAPKK Activity
Activation Of MAPK Activity
Negative Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Phosphorylation
Protein Phosphorylation
Endocytosis
Autophagy
Response To Oxidative Stress
Small GTPase Mediated Signal Transduction
Neuromuscular Junction Development
Determination Of Adult Lifespan
Positive Regulation Of Autophagy
Regulation Of Protein Kinase A Signaling
Negative Regulation Of Protein Processing
Regulation Of Neuron Maturation
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Olfactory Bulb Development
Tangential Migration From The Subventricular Zone To The Olfactory Bulb
Positive Regulation Of Protein Ubiquitination
Negative Regulation Of Protein Binding
Positive Regulation Of Protein Binding
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of GTPase Activity
Cellular Response To Oxidative Stress
Cellular Protein Localization
Intracellular Signal Transduction
Regulation Of Kidney Size
Exploration Behavior
Locomotory Exploration Behavior
Regulation Of Locomotion
Regulation Of Membrane Potential
Positive Regulation Of Programmed Cell Death
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of GTPase Activity
Protein Autophosphorylation
Intracellular Distribution Of Mitochondria
Neuron Projection Morphogenesis
Regulation Of Mitochondrial Depolarization
Regulation Of Synaptic Transmission, Glutamatergic
Regulation Of Excitatory Postsynaptic Membrane Potential
Regulation Of Dopamine Receptor Signaling Pathway
Positive Regulation Of Dopamine Receptor Signaling Pathway
Regulation Of Dendritic Spine Morphogenesis
Protein Localization To Mitochondrion
Neuron Death
Cellular Response To Manganese Ion
Reactive Oxygen Species Metabolic Process
Regulation Of Mitochondrial Fission
Regulation Of Neuron Death
Negative Regulation Of Neuron Death
Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Protein Autoubiquitination
Regulation Of Neuroblast Proliferation
Regulation Of Synaptic Vesicle Transport
Negative Regulation Of Late Endosome To Lysosome Transport
Negative Regulation Of Thioredoxin Peroxidase Activity By Peptidyl-threonine Phosphorylation
Negative Regulation Of Hydrogen Peroxide-induced Cell Death
Negative Regulation Of Protein Targeting To Mitochondrion
Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion
Cellular Response To Dopamine
Regulation Of Branching Morphogenesis Of A Nerve
Regulation Of Synaptic Vesicle Exocytosis
Negative Regulation Of Peroxidase Activity
Pathways
Drugs
Diseases
GWAS
Crohn's disease (
18587394
21102463
)
Inflammatory bowel disease (
23128233
)
Obesity-related traits (
23251661
)
Parkinson's disease (
21292315
19915576
22438815
21738487
)
Protein-Protein Interactions
9 interactors:
ALG2
CEP55
CHMP4B
DDX24
GRB2
LRRK2
NOTCH2NL
PSMA3
TRIM27
33 interactors:
ACTB
AKT1
ARFGAP1
ARHGEF7
BAG5
DVL1
DVL2
DVL3
EIF4EBP1
HSPD1
L3MBTL3
LRP6
MAP1B
MAP2K3
MAP2K4
MAP2K6
MAP2K7
MAPT
MBP
PRKCZ
PTPN23
RALYL
RIPK2
SH3GL1
SH3GL2
SH3GL3
STK24
STK25
STK3
STRBP
TAOK3
TRAF2
TUBA1A
Entrez ID
25930
120892
HPRD ID
05959
10613
Ensembl ID
ENSG00000076201
ENSG00000188906
Uniprot IDs
B4DST5
Q9H3S7
Q17RV3
Q5S007
PDB IDs
3RAU
2ZEJ
3D6T
Enriched GO Terms of Interacting Partners
?
Cell Separation After Cytokinesis
Regulation Of Viral Release From Host Cell
Positive Regulation Of Proteolysis
Regulation Of Protein Complex Assembly
Regulation Of Organelle Organization
Protein Localization
Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion
Negative Regulation Of Protein Targeting To Mitochondrion
Negative Regulation Of Thioredoxin Peroxidase Activity By Peptidyl-threonine Phosphorylation
Protein Glycosylation In Endoplasmic Reticulum
Negative Regulation Of Peroxidase Activity
Negative Regulation Of Signal Transduction
Protein Oligomerization
Signal Transduction In Response To DNA Damage
Negative Regulation Of Signaling
Regulation Of Cytoskeleton Organization
Positive Regulation Of Actin Filament Polymerization
Regulation Of Autophagy
Negative Regulation Of Interleukin-2 Secretion
Negative Regulation Of Late Endosome To Lysosome Transport
Positive Regulation Of Protein Autoubiquitination
Positive Regulation Of Protein Polymerization
Viral Process
Cellular Response To Dopamine
Negative Regulation Of Autophagic Vacuole Assembly
Regulation Of Protein Autoubiquitination
Positive Regulation Of Dopamine Receptor Signaling Pathway
Maintenance Of Lens Transparency
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Vesicle-mediated Transport
Establishment Of Protein Localization
Positive Regulation Of Cellular Protein Catabolic Process
Regulation Of Protein Targeting To Mitochondrion
Regulation Of Branching Morphogenesis Of A Nerve
Regulation Of Kidney Size
Regulation Of Viral Process
Cellular Response To Stress
Regulation Of Proteolysis
Mitotic Cell Cycle Process
Regulation Of Cell Death
Protein Polyubiquitination
Positive Regulation Of Protein Complex Assembly
Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway
Cellular Response To Manganese Ion
Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Regulation Of Actin Filament Polymerization
Negative Regulation Of Protein Transport
Negative Regulation Of Calcium Ion Import
Intracellular Distribution Of Mitochondria
Regulation Of Protein Kinase Activity
Positive Regulation Of Protein Kinase Activity
Regulation Of Kinase Activity
Positive Regulation Of Kinase Activity
Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Protein Serine/threonine Kinase Activity
Positive Regulation Of Transferase Activity
Positive Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade
Positive Regulation Of MAPK Cascade
Regulation Of MAPK Cascade
Regulation Of JNK Cascade
Regulation Of Protein Phosphorylation
Positive Regulation Of Phosphorylation
Regulation Of Phosphorylation
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of JNK Cascade
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of MAP Kinase Activity
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Signal Transduction
Intracellular Signal Transduction
Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Modification Process
Anatomical Structure Development
Signal Transduction By Phosphorylation
Regulation Of Catalytic Activity
Regulation Of MAP Kinase Activity
Regulation Of Signal Transduction
Toll-like Receptor Signaling Pathway
Signaling
Regulation Of Intracellular Signal Transduction
Cell Communication
Positive Regulation Of Catalytic Activity
Positive Regulation Of Intracellular Signal Transduction
TRIF-dependent Toll-like Receptor Signaling Pathway
Signal Transduction
Cell Death
Death
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
MyD88-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of JUN Kinase Activity
Developmental Process
Regulation Of Signaling
Activation Of Innate Immune Response
Tagcloud
?
autosomal
decline
difficulty
dj1
england
g2019s
gait
gu
hoehn
idiopathic
leucine
motor
movement
parkinson
pd
pigd
pink1
postural
prkn
rating
schwab
snca
society
staging
udrs
undefined
unified
updrs
yahr
Tagcloud (Difference)
?
autosomal
decline
difficulty
dj1
england
g2019s
gait
gu
hoehn
idiopathic
leucine
motor
movement
parkinson
pd
pigd
pink1
postural
prkn
rating
schwab
snca
society
staging
udrs
undefined
unified
updrs
yahr
Tagcloud (Intersection)
?