PTPN23 and CHMP4B

Number of citations of the paper that reports this interaction (PMID 17174262)
10

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		PTPN23	CHMP4B
Gene Name		protein tyrosine phosphatase, non-receptor type 23	charged multivesicular body protein 4B
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Cytoplasmic Membrane-bounded Vesicle Ciliary Basal Body Extracellular Vesicular Exosome	ESCRT III Complex Nucleus Cytoplasm Endosome Cytosol Cytoplasmic Side Of Plasma Membrane Midbody Late Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Binding Protein Kinase Binding	Protein Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Epithelial Cell Migration Protein Transport Peptidyl-tyrosine Dephosphorylation Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Cilium Morphogenesis Positive Regulation Of Homophilic Cell Adhesion Positive Regulation Of Adherens Junction Organization Positive Regulation Of Early Endosome To Late Endosome Transport	Cell Separation After Cytokinesis Posttranslational Protein Targeting To Membrane Nucleus Organization Vacuolar Transport Mitotic Metaphase Plate Congression Regulation Of Centrosome Duplication Viral Process Endosomal Transport Viral Life Cycle Maintenance Of Lens Transparency Viral Budding Via Host ESCRT Complex Viral Budding Regulation Of Viral Process Protein Homooligomerization Negative Regulation Of Cell Death Membrane Organization Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Neuron Death Regulation Of Mitotic Spindle Assembly Positive Regulation Of Viral Release From Host Cell Negative Regulation Of Autophagic Vacuole Assembly
Pathways			HIV Life Cycle Budding and maturation of HIV virion HIV Infection Endosomal Sorting Complex Required For Transport (ESCRT) Late Phase of HIV Life Cycle
Drugs
Diseases
GWAS			Stearic acid (18:0) plasma levels ( 23362303)
Protein-Protein Interactions		9 interactors: ALG2 CEP55 CHMP4B DDX24 GRB2 LRRK2 NOTCH2NL PSMA3 TRIM27	14 interactors: CHMP1B CHMP3 CHMP4A CHMP4C CHMP5 CHMP6 EXOSC9 HIPK2 PDCD6IP PIAS2 PTPN23 STAMBP UBE2I VPS4A
Entrez ID		25930	128866
HPRD ID		05959	16642
Ensembl ID		ENSG00000076201	ENSG00000101421
Uniprot IDs		B4DST5 Q9H3S7	Q9H444
PDB IDs		3RAU	3C3Q 3UM3 4ABM
Enriched GO Terms of Interacting Partners?		Cell Separation After Cytokinesis Regulation Of Viral Release From Host Cell Positive Regulation Of Proteolysis Regulation Of Protein Complex Assembly Regulation Of Organelle Organization Protein Localization Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion Negative Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Thioredoxin Peroxidase Activity By Peptidyl-threonine Phosphorylation Protein Glycosylation In Endoplasmic Reticulum Negative Regulation Of Peroxidase Activity Negative Regulation Of Signal Transduction Protein Oligomerization Signal Transduction In Response To DNA Damage Negative Regulation Of Signaling Regulation Of Cytoskeleton Organization Positive Regulation Of Actin Filament Polymerization Regulation Of Autophagy Negative Regulation Of Interleukin-2 Secretion Negative Regulation Of Late Endosome To Lysosome Transport Positive Regulation Of Protein Autoubiquitination Positive Regulation Of Protein Polymerization Viral Process Cellular Response To Dopamine Negative Regulation Of Autophagic Vacuole Assembly Regulation Of Protein Autoubiquitination Positive Regulation Of Dopamine Receptor Signaling Pathway Maintenance Of Lens Transparency Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Vesicle-mediated Transport Establishment Of Protein Localization Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Protein Targeting To Mitochondrion Regulation Of Branching Morphogenesis Of A Nerve Regulation Of Kidney Size Regulation Of Viral Process Cellular Response To Stress Regulation Of Proteolysis Mitotic Cell Cycle Process Regulation Of Cell Death Protein Polyubiquitination Positive Regulation Of Protein Complex Assembly Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Cellular Response To Manganese Ion Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Actin Filament Polymerization Negative Regulation Of Protein Transport Negative Regulation Of Calcium Ion Import Intracellular Distribution Of Mitochondria	Cell Separation After Cytokinesis Cell Division Mitotic Metaphase Plate Congression Metaphase Plate Congression Establishment Of Chromosome Localization Nucleus Organization Vacuolar Transport Mitotic Sister Chromatid Segregation Viral Process Sister Chromatid Segregation Viral Life Cycle Chromosome Segregation Regulation Of Centrosome Duplication Regulation Of Centrosome Cycle Mitotic Nuclear Division Mitotic Cell Cycle Process Endosomal Transport Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Mitotic Cell Cycle Viral Budding Via Host ESCRT Complex Regulation Of Mitotic Spindle Assembly Protein Transport Viral Budding Regulation Of Microtubule Cytoskeleton Organization Establishment Of Organelle Localization Regulation Of Spindle Assembly Establishment Of Protein Localization Cell Cycle Process Regulation Of Microtubule-based Process Regulation Of Mitotic Spindle Organization Organelle Localization Regulation Of Cell Cycle Process Protein Localization Membrane Organization Cell Cycle Virion Assembly Regulation Of Cell Cycle Regulation Of Cellular Component Organization Abscission Cellular Macromolecule Catabolic Process Regulation Of Cytoskeleton Organization Regulation Of Organelle Organization Positive Regulation Of Viral Release From Host Cell Intracellular Transport Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Cell Division Cellular Protein Catabolic Process Negative Regulation Of Cytokinesis Membrane Budding Organelle Organization
Tagcloud ?			aculeiform adcc arg58his beaded bfsp1 bfsp2 cataract cerulean connexins coralliform cryaa cryba2 cryba4 crybb1 crybb3 cryga crygb crygc crygd crygs crystallins fasciculiform flaky gja3 gja8 lim2 macedonia pro23thr tmem114
Tagcloud (Difference) ?			aculeiform adcc arg58his beaded bfsp1 bfsp2 cataract cerulean connexins coralliform cryaa cryba2 cryba4 crybb1 crybb3 cryga crygb crygc crygd crygs crystallins fasciculiform flaky gja3 gja8 lim2 macedonia pro23thr tmem114
Tagcloud (Intersection) ?