PTPN23 and ALG2

Number of citations of the paper that reports this interaction (PubMedID 17174262)
0

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		PTPN23	ALG2
Description		protein tyrosine phosphatase non-receptor type 23	ALG2 alpha-1,3/1,6-mannosyltransferase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Cytoskeleton Cilium Nuclear Body Cytoplasmic Vesicle Centriolar Satellite Ciliary Basal Body Cell Projection Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endomembrane System Membrane Cytoplasmic Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Protein Kinase Binding	Alpha-1,3-mannosyltransferase Activity GDP-Man:Man(1)GlcNAc(2)-PP-Dol Alpha-1,3-mannosyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity GDP-Man:Man(2)GlcNAc(2)-PP-Dol Alpha-1,6-mannosyltransferase Activity
	Biological Process	Negative Regulation Of Epithelial Cell Migration Protein Transport Cell Projection Organization Endocytic Recycling Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Early Endosome To Late Endosome Transport Cilium Assembly Positive Regulation Of Wnt Protein Secretion Positive Regulation Of Homophilic Cell Adhesion Positive Regulation Of Adherens Junction Organization Positive Regulation Of Early Endosome To Late Endosome Transport	Protein Glycosylation Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process
Pathways		Interleukin-37 signaling	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG2 causes CDG-1i
Drugs
Diseases			Congenital disorders of glycosylation (CDG) type I
GWAS		C-reactive protein levels ( 30388399) Refractive error ( 32231278) Type 2 diabetes (adjusted for BMI) ( 29632382)	Asthma ( 31959851 34103634) Callous-unemotional behaviour ( 23874384) Gestational age at birth (maternal effect) ( 28877031)
Interacting Genes		12 interacting genes: ALG2 BICD1 CEP19 CEP55 CHMP4B DDX24 LRRK2 NOTCH2NLA PSMA3 TRIM27 UBAP1 WDR4	4 interacting genes: ANXA11 PEF1 PTPN23 SRI
Entrez ID		25930	85365
HPRD ID		05959	09716
Ensembl ID		ENSG00000076201	ENSG00000119523
Uniprot IDs		B4DST5 Q9H3S7	A0A0A0MTE0 Q9H553
PDB IDs		3RAU 5CRU 5CRV 5LM1 5LM2 5MJY 5MJZ 5MK0 5MK1 5MK2 5MK3
Enriched GO Terms of Interacting Partners?		Organelle Localization Microtubule Anchoring Microtubule Anchoring At Microtubule Organizing Center Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Multivesicular Body Organization Mitotic Cytokinetic Process Midbody Abscission Late Endosome To Vacuole Transport Vesicle-mediated Transport Intracellular Transport Endosomal Transport Membrane Organization Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Fission Multivesicular Body Sorting Pathway Metaphase Chromosome Alignment Cytokinetic Process Mitotic Metaphase Chromosome Alignment Vesicle Targeting, Trans-Golgi To Periciliary Membrane Compartment GDP-Man:Man(1)GlcNAc(2)-PP-Dol Alpha-1,3-mannosyltransferase Activity GDP-Man:Man(2)GlcNAc(2)-PP-Dol Alpha-1,6-mannosyltransferase Activity Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Negative Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Organelle Assembly Endosome TRNA Methyltransferase Activator Activity TRNA (m7G46) Methyltransferase Complex Mitotic Cytokinesis Chromosome Localization Alpha-1,3-mannosyltransferase Activity Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion Beta-catenin Destruction Complex Binding Endosome Organization Establishment Of Protein Localization To Organelle Proteinase Activated Receptor Binding Negative Regulation Of Catabolic Process TRNA (guanine-N7)-methylation Cytoskeleton-dependent Cytokinesis Nucleus Organization Regulation Of Notch Signaling Pathway Positive Regulation Of Protein Autoubiquitination Response To Curcumin	Calcium-dependent Protein Binding Extracellular Exosome Calcium Ion Binding Positive Regulation Of Homophilic Cell Adhesion Response To Calcium Ion Positive Regulation Of Adherens Junction Organization Vesicle-mediated Transport Negative Regulation Of Cardiac Muscle Contraction Positive Regulation Of Wnt Protein Secretion Regulation Of Adherens Junction Organization Regulation Of Homophilic Cell Adhesion Positive Regulation Of Protein Monoubiquitination Regulation Of Protein Secretion Regulation Of Protein Monoubiquitination Negative Regulation Of Striated Muscle Contraction Chromaffin Granule Membrane Neural Crest Formation Response To Metal Ion Positive Regulation Of Early Endosome To Late Endosome Transport Protein Heterodimerization Activity Azurophil Granule Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Phosphatidylethanolamine Binding S100 Protein Binding Specific Granule Regulation Of Cell Communication By Electrical Coupling Regulation Of Relaxation Of Muscle Negative Regulation Of Heart Rate Regulation Of Protein Transport Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Epithelial Cell Migration COPII Vesicle Coat Regulation Of Early Endosome To Late Endosome Transport Negative Regulation Of Muscle Contraction Negative Regulation Of Heart Contraction Regulation Of Establishment Of Protein Localization Negative Regulation Of Blood Circulation Regulation Of Cellular Localization Early Endosome To Late Endosome Transport COPII Vesicle Coating MHC Class II Protein Complex Binding Regulation Of Secretion By Cell Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Neural Crest Cell Development Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Cardiac Muscle Cell Contraction Regulation Of Secretion Vesicle Membrane Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum
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