FXN and ACTN1

Number of citations of the paper that reports this interaction (PubMedID 16713569)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		FXN	ACTN1
Description		frataxin	actinin alpha 1
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Mitochondrial [2Fe-2S] Assembly Complex Iron-sulfur Cluster Assembly Complex	Stress Fiber Ruffle Extracellular Region Extracellular Space Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Brush Border Cell-cell Junction Fascia Adherens Focal Adhesion Actin Cytoskeleton Membrane Sarcomere Z Disc Cell Junction Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Cell Projection Synapse Extracellular Exosome Anchoring Junction Glutamatergic Synapse
	Molecular Function	Ferroxidase Activity Protein Binding Enzyme Activator Activity Ferrous Iron Binding Ferric Iron Binding Oxidoreductase Activity Iron Chaperone Activity Metal Ion Binding 2 Iron, 2 Sulfur Cluster Binding	Transcription Coactivator Activity Double-stranded RNA Binding Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Vinculin Binding Identical Protein Binding Protein Homodimerization Activity Transmembrane Transporter Binding Metal Ion Binding Actin Filament Binding Structural Constituent Of Postsynapse
	Biological Process	Oxidative Phosphorylation Heme Biosynthetic Process Monoatomic Ion Transport Iron Ion Transport Intracellular Iron Ion Homeostasis Mitochondrion Organization Adult Walking Behavior Aerobic Respiration Embryo Development Ending In Birth Or Egg Hatching Response To Iron Ion Iron-sulfur Cluster Assembly Protein Autoprocessing Proprioception Intracellular Monoatomic Cation Homeostasis Mitochondrial Respiratory Chain Complex III Assembly Organ Growth Regulation Of Growth Negative Regulation Of Multicellular Organism Growth Negative Regulation Of Apoptotic Process [2Fe-2S] Cluster Assembly [4Fe-4S] Cluster Assembly Negative Regulation Of Organ Growth Muscle Cell Cellular Homeostasis Positive Regulation Of Lyase Activity Protein Maturation Cellular Response To Hydrogen Peroxide Negative Regulation Of Release Of Cytochrome C From Mitochondria Inorganic Ion Homeostasis	Actin Filament Organization Actin Cytoskeleton Organization Platelet Activation Platelet Formation Platelet Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Focal Adhesion Assembly Anatomical Structure Formation Involved In Morphogenesis Actin Filament Bundle Assembly Actin Filament Network Formation Muscle Cell Development Platelet Aggregation Postsynapse Organization
Pathways		Mitochondrial protein import Mitochondrial protein import Mitochondrial iron-sulfur cluster biogenesis Maturation of TCA enzymes and regulation of TCA cycle Complex III assembly	Platelet degranulation Syndecan interactions Nephrin family interactions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components RHOD GTPase cycle RHOBTB2 GTPase cycle RHOF GTPase cycle
Drugs		Iron Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate	Human calcitonin Copper
Diseases		Friedreich ataxia
GWAS		Headache ( 29397368) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Myopia ( 27182965) Night sleep phenotypes ( 27126917) Refractive error ( 32231278) Seasonality ( 25562672)	Asthma ( 31959851) Cognitive decline rate in late mild cognitive impairment ( 26252872) Feeling fed-up ( 29500382) Feeling hurt ( 29500382) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422) High light scatter reticulocyte count ( 32888494) Lack of perseverance ( 30718321) Mean platelet volume ( 27863252 32888494) Medication use (drugs used in diabetes) ( 31015401) Mosquito bite size ( 28199695) Neurociticism ( 29500382) Periodontitis (Mean PAL) ( 24024966) Platelet count ( 29403010 26805783 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 32888494) Prostate cancer ( 23535732) Rheumatoid arthritis (ACPA-positive) ( 23143596) Smoking behavior ( 19247474) Urinary albumin excretion ( 30220432)
Interacting Genes		7 interacting genes: ACTN1 AKT1 DAPP1 GOLGA6L9 PICK1 PMPCB RNF126	93 interacting genes: ACTN3 ADORA2A APC APPBP2 ATXN2 ATXN7 CACNA1A CAMK2A CBY2 CDK5 CDK5R1 CDK5R2 CEBPA CLIC5 COIL COL17A1 CSRP1 CSRP3 CTNNA1 DDIAS DSCAM DYNLT1 EIF2S1 EPM2AIP1 ERBIN FBP1 FILNC1 FXN FXR1 GADD45G GFI1B GIPC1 GIT2 GRIA4 GRIN2A GRM5 GTF2H1 HSPB1 ICAM5 ITGB1 KAT2B KCTD6 KPNA2 LINC01554 LNX1 LPP MAGEA11 MAP2 MAP3K1 MED14 MICALL2 MTDH MTNR1A MTNR1B MYOT MYOZ1 MYOZ2 MYOZ3 NEBL NKAPD1 NR1H3 NUMBL OAS1 PALLD PDHX PDLIM1 PDLIM5 PIAS4 PKD1 PKN1 PLD2 PSEN1 PSMA1 PTK2 PTPN1 PTPN6 PYGB RAVER1 RPS27 SIRPA SLC2A4 SORBS2 SRC SSX2IP SYNPO2L TES TSC1 TTN TXN USP2 VCL XRCC4 ZYX
Entrez ID		2395	87
HPRD ID		06013	00020
Ensembl ID		ENSG00000165060	ENSG00000072110
Uniprot IDs		A0A0S2Z3G4 Q16595	A0A024R694 A0A7I2V4Y4 A0A804HL31 A0A804HLF4 H9KV75 P12814
PDB IDs		1EKG 1LY7 3S4M 3S5D 3S5E 3S5F 3T3J 3T3K 3T3L 3T3T 3T3X 5KZ5 6NZU 8PK8 8PK9 8RME	2EYI 2EYN 2N8Y 2N8Z
Enriched GO Terms of Interacting Partners?		Protein K29-linked Ubiquitination Mitochondrial Calcium Ion Transmembrane Transport Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Postsynapse Organization Platelet Morphogenesis Structural Constituent Of Postsynapse Protein Modification Process Positive Regulation Of Protein Localization To Endoplasmic Reticulum Response To Insulin-like Growth Factor Stimulus Protein Metabolic Process Protein Maturation Mammalian Oogenesis Stage Regulation Of Ketone Metabolic Process Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Negative Regulation Of Small Molecule Metabolic Process TRNA (guanine-N7)-methylation Regulation Of Steroid Biosynthetic Process Negative Regulation Of Lipid Metabolic Process TORC2 Complex Binding Cellular Response To Rapamycin Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Deoxyribonuclease Activity Negative Regulation Of Protein Localization To Lysosome Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Regulation Of TRNA Methylation Positive Regulation Of Endodeoxyribonuclease Activity Regulation Of Steroid Metabolic Process SREBP-SCAP Complex Retention In Endoplasmic Reticulum Vitamin Binding Gamma-glutamyl Carboxylase Activity Negative Regulation Of Bone Development Negative Regulation Of Testosterone Biosynthetic Process Phospholipid Binding Membrane Curvature Sensor Activity Protein Processing Involved In Protein Targeting To Mitochondrion Mitochondrial Processing Peptidase Complex Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System Cytoplasm Protein Quality Control Cellular Response To Decreased Oxygen Levels Actin Filament Binding Fascia Adherens Actin Filament Network Formation Response To Rapamycin Cellular Response To Oxygen Levels Nitric-oxide Synthase Regulator Activity Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Negative Regulation Of SREBP Signaling Pathway Calcium Ion Transmembrane Transport Negative Regulation Of Fatty Acid Beta-oxidation	Z Disc Cell Adhesion Cytoplasm Actin Binding Actin Cytoskeleton Actinin Binding Actin Cytoskeleton Organization Telethonin Binding Anchoring Junction Actomyosin Structure Organization Actin Filament-based Process Cell-cell Adhesion Cytoskeleton Organization Sarcomere Organization Structural Constituent Of Muscle Focal Adhesion Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Stress Fiber Cell Junction Organization Cell Projection Protein Kinase 5 Complex Cell-substrate Adhesion Regulation Of Protein Localization Regulation Of Programmed Cell Death Muscle Alpha-actinin Binding Negative Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Dendritic Spine FATZ Binding Regulation Of Apoptotic Process Cell-matrix Adhesion Regulation Of Multicellular Organismal Process Regulation Of Synaptic Transmission, Glutamatergic Negative Regulation Of Cell Communication Protein Binding Negative Regulation Of Signaling Neuronal Cell Body Synaptic Transmission, Glutamatergic Regulation Of Intracellular Signal Transduction Detection Of Muscle Stretch Organelle Organization Protein Kinase Binding Positive Regulation Of Apoptotic Process Contractile Actin Filament Bundle Assembly Stress Fiber Assembly Regulation Of Generation Of Precursor Metabolites And Energy Cadherin Binding Cellular Response To Amyloid-beta
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