FXN and PMPCB

Number of citations of the paper that reports this interaction (PMID 9700204)
19

Data Source:
HPRD (in vitro, two hybrid)

		FXN	PMPCB
Gene Name		frataxin	peptidase (mitochondrial processing) beta
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Cytosol	Mitochondrial Inner Membrane Mitochondrial Matrix
	Molecular Function	Ferroxidase Activity Protein Binding Ferrous Iron Binding Ferric Iron Binding Iron Chaperone Activity Iron-sulfur Cluster Binding 2 Iron, 2 Sulfur Cluster Binding	Metalloendopeptidase Activity Metal Ion Binding
	Biological Process	Oxidative Phosphorylation Heme Biosynthetic Process Ion Transport Cellular Iron Ion Homeostasis Mitochondrion Organization Adult Walking Behavior Positive Regulation Of Cell Proliferation Aerobic Respiration Embryo Development Ending In Birth Or Egg Hatching Response To Iron Ion Regulation Of Ferrochelatase Activity Protein Autoprocessing Iron Incorporation Into Metallo-sulfur Cluster Proprioception Positive Regulation Of Cell Growth Negative Regulation Of Multicellular Organism Growth Negative Regulation Of Apoptotic Process Small Molecule Metabolic Process Negative Regulation Of Organ Growth Positive Regulation Of Metalloenzyme Activity Positive Regulation Of Transferase Activity Positive Regulation Of Lyase Activity Positive Regulation Of Oxidoreductase Activity Cellular Response To Hydrogen Peroxide Negative Regulation Of Release Of Cytochrome C From Mitochondria	Proteolysis Protein Targeting To Mitochondrion Cellular Protein Metabolic Process
Pathways		Mitochondrial iron-sulfur cluster biogenesis Mitochondrial protein import	Mitochondrial protein import
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: ACTN1 PICK1 PMPCB	3 interactors: FXN MARK3 PMPCA
Entrez ID		2395	9512
HPRD ID		06013	07539
Ensembl ID		ENSG00000165060	ENSG00000105819
Uniprot IDs		Q16595	B3KM34 E7ERZ4 O75439 Q96CP5
PDB IDs		1EKG 1LY7 3S4M 3S5D 3S5E 3S5F 3T3J 3T3K 3T3L 3T3T 3T3X
Enriched GO Terms of Interacting Partners?		Protein Localization To Tight Junction Protein Localization Establishment Of Localization In Cell DNA Methylation Involved In Embryo Development Protein Targeting Protein Localization To Cell Junction Cellular Localization Dendritic Spine Maintenance Neuronal Ion Channel Clustering Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Negative Regulation Of Actin Nucleation Long Term Synaptic Depression Actin Crosslink Formation Positive Regulation Of Receptor Internalization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Dendritic Spine Organization DNA Methylation Involved In Gamete Generation Regulation Of Actin Nucleation Cellular Response To Glucose Starvation Monoamine Transport Cellular Component Maintenance Neuron Maturation Regulation Of Receptor Internalization Focal Adhesion Assembly Intracellular Protein Transport Retrograde Vesicle-mediated Transport, Golgi To ER Positive Regulation Of Receptor-mediated Endocytosis Adherens Junction Assembly Tight Junction Assembly Cell-substrate Junction Assembly Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Receptor Clustering DNA Methylation Negative Regulation Of Synaptic Transmission Actin Filament Bundle Assembly Protein Targeting To Mitochondrion Platelet Degranulation Apical Junction Assembly Protein Localization To Mitochondrion Transport Cellular Protein Localization Protein Transport Vesicle-mediated Transport DNA Modification Adherens Junction Organization Establishment Of Protein Localization Intracellular Transport Cellular Response To Decreased Oxygen Levels Glial Cell Development Positive Regulation Of Endocytosis	Regulation Of Ferrochelatase Activity Iron Incorporation Into Metallo-sulfur Cluster Proprioception Mitochondrion Organization Positive Regulation Of Metalloenzyme Activity Protein Autoprocessing Neuromuscular Process Controlling Posture Negative Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Multicellular Organism Growth Iron-sulfur Cluster Assembly Heme Biosynthetic Process Negative Regulation Of Mitochondrion Organization Response To Iron Ion Porphyrin-containing Compound Biosynthetic Process Negative Regulation Of Organ Growth Positive Regulation Of Oxidoreductase Activity Heme Metabolic Process Positive Regulation Of Lyase Activity Adult Walking Behavior Cellular Protein Metabolic Process Porphyrin-containing Compound Metabolic Process Pigment Biosynthetic Process Cellular Response To Hydrogen Peroxide Aerobic Respiration Protein Targeting To Mitochondrion Oxidative Phosphorylation Protein Localization To Mitochondrion Regulation Of Oxidoreductase Activity
Tagcloud ?		astrocyte astrocytes ataxia autonomous biogenesis conditioned detrimental drives fa frataxin friedreich gaa glia homozygous intron lentivirus manifestations neurite neurodegenerative provoked recessive shrna shrna37 sulfur superoxide take transduced ubiquitous underlining
Tagcloud (Difference) ?		astrocyte astrocytes ataxia autonomous biogenesis conditioned detrimental drives fa frataxin friedreich gaa glia homozygous intron lentivirus manifestations neurite neurodegenerative provoked recessive shrna shrna37 sulfur superoxide take transduced ubiquitous underlining
Tagcloud (Intersection) ?