FXN and RNF126

Number of citations of the paper that reports this interaction (PubMedID 28228265)
63

Data Source:
BioGRID (enzymatic study)

		FXN	RNF126
Description		frataxin	ring finger protein 126
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Mitochondrial [2Fe-2S] Assembly Complex Iron-sulfur Cluster Assembly Complex	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Ferroxidase Activity Protein Binding Enzyme Activator Activity Ferrous Iron Binding Ferric Iron Binding Oxidoreductase Activity Iron Chaperone Activity Metal Ion Binding 2 Iron, 2 Sulfur Cluster Binding	Epidermal Growth Factor Receptor Binding Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Oxidative Phosphorylation Heme Biosynthetic Process Monoatomic Ion Transport Iron Ion Transport Intracellular Iron Ion Homeostasis Mitochondrion Organization Adult Walking Behavior Aerobic Respiration Embryo Development Ending In Birth Or Egg Hatching Response To Iron Ion Iron-sulfur Cluster Assembly Protein Autoprocessing Proprioception Intracellular Monoatomic Cation Homeostasis Mitochondrial Respiratory Chain Complex III Assembly Organ Growth Regulation Of Growth Negative Regulation Of Multicellular Organism Growth Negative Regulation Of Apoptotic Process [2Fe-2S] Cluster Assembly [4Fe-4S] Cluster Assembly Negative Regulation Of Organ Growth Muscle Cell Cellular Homeostasis Positive Regulation Of Lyase Activity Protein Maturation Cellular Response To Hydrogen Peroxide Negative Regulation Of Release Of Cytochrome C From Mitochondria Inorganic Ion Homeostasis	Protein Polyubiquitination Double-strand Break Repair Via Homologous Recombination Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Protein Ubiquitination Protein K29-linked Ubiquitination Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Population Proliferation Retrograde Transport, Endosome To Golgi Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein K27-linked Ubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System DNA Strand Resection Involved In Replication Fork Processing Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		Mitochondrial protein import Mitochondrial protein import Mitochondrial iron-sulfur cluster biogenesis Maturation of TCA enzymes and regulation of TCA cycle Complex III assembly	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Iron Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate
Diseases		Friedreich ataxia
GWAS		Headache ( 29397368) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Myopia ( 27182965) Night sleep phenotypes ( 27126917) Refractive error ( 32231278) Seasonality ( 25562672)	Arterial stiffness ( 31070453) Arterial stiffness index ( 31235810) Pulse pressure ( 30578418)
Interacting Genes		7 interacting genes: ACTN1 AKT1 DAPP1 GOLGA6L9 PICK1 PMPCB RNF126	42 interacting genes: ABCG2 AICDA BAG6 CENPP CSNK2B E2F1 EGFR FXN G0S2 HMGCL MAP3K1 MDM2 MIEN1 NUDT3 OTUB1 OTUB2 PLK1 PSMF1 RBX1 RNF168 SFN SNUPN TARDBP TRIM11 TRIM23 TRIM26 TRIM52 TSG101 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2E3 UBE2N UBL3 UBL4A USP15 USP2 XRCC5 XRCC6
Entrez ID		2395	55658
HPRD ID		06013	11501
Ensembl ID		ENSG00000165060	ENSG00000070423
Uniprot IDs		A0A0S2Z3G4 Q16595	A8K0Q1 Q9BV68
PDB IDs		1EKG 1LY7 3S4M 3S5D 3S5E 3S5F 3T3J 3T3K 3T3L 3T3T 3T3X 5KZ5 6NZU 8PK8 8PK9 8RME	2N9O 2N9P
Enriched GO Terms of Interacting Partners?		Protein K29-linked Ubiquitination Mitochondrial Calcium Ion Transmembrane Transport Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Postsynapse Organization Platelet Morphogenesis Structural Constituent Of Postsynapse Protein Modification Process Positive Regulation Of Protein Localization To Endoplasmic Reticulum Response To Insulin-like Growth Factor Stimulus Protein Metabolic Process Protein Maturation Mammalian Oogenesis Stage Regulation Of Ketone Metabolic Process Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Negative Regulation Of Small Molecule Metabolic Process TRNA (guanine-N7)-methylation Regulation Of Steroid Biosynthetic Process Negative Regulation Of Lipid Metabolic Process TORC2 Complex Binding Cellular Response To Rapamycin Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Deoxyribonuclease Activity Negative Regulation Of Protein Localization To Lysosome Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Regulation Of TRNA Methylation Positive Regulation Of Endodeoxyribonuclease Activity Regulation Of Steroid Metabolic Process SREBP-SCAP Complex Retention In Endoplasmic Reticulum Vitamin Binding Gamma-glutamyl Carboxylase Activity Negative Regulation Of Bone Development Negative Regulation Of Testosterone Biosynthetic Process Phospholipid Binding Membrane Curvature Sensor Activity Protein Processing Involved In Protein Targeting To Mitochondrion Mitochondrial Processing Peptidase Complex Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System Cytoplasm Protein Quality Control Cellular Response To Decreased Oxygen Levels Actin Filament Binding Fascia Adherens Actin Filament Network Formation Response To Rapamycin Cellular Response To Oxygen Levels Nitric-oxide Synthase Regulator Activity Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Negative Regulation Of SREBP Signaling Pathway Calcium Ion Transmembrane Transport Negative Regulation Of Fatty Acid Beta-oxidation	Post-translational Protein Modification Protein Modification Process Protein Ubiquitination Ubiquitin-protein Transferase Activity Protein Metabolic Process Ubiquitin Conjugating Enzyme Activity Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Proteolysis Macromolecule Metabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Polyubiquitination Ubiquitin Protein Ligase Binding Cytosol Protein K48-linked Ubiquitination Ubiquitin Protein Ligase Activity Macromolecule Catabolic Process Negative Regulation Of Macromolecule Metabolic Process DNA Damage Response Protein K11-linked Ubiquitination Nucleus Negative Regulation Of Metabolic Process Ubiquitin Binding Transferase Activity Protein Monoubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Protein K63-linked Ubiquitination Catabolic Process Protein-containing Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Proteasomal Protein Catabolic Process Nucleoplasm Cellular Response To Stress Regulation Of Protein Modification Process Negative Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Protein Catabolic Process Double-strand Break Repair Via Nonhomologous End Joining Response To Stress Protein Catabolic Process Cytoplasm Negative Regulation Of Proteasomal Protein Catabolic Process
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