FXN

Description		frataxin
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Mitochondrial [2Fe-2S] Assembly Complex Iron-sulfur Cluster Assembly Complex
	Molecular Function	Ferroxidase Activity Protein Binding Enzyme Activator Activity Ferrous Iron Binding Ferric Iron Binding Oxidoreductase Activity Iron Chaperone Activity Metal Ion Binding 2 Iron, 2 Sulfur Cluster Binding
	Biological Process	Oxidative Phosphorylation Heme Biosynthetic Process Monoatomic Ion Transport Iron Ion Transport Intracellular Iron Ion Homeostasis Mitochondrion Organization Adult Walking Behavior Aerobic Respiration Embryo Development Ending In Birth Or Egg Hatching Response To Iron Ion Iron-sulfur Cluster Assembly Protein Autoprocessing Proprioception Intracellular Monoatomic Cation Homeostasis Mitochondrial Respiratory Chain Complex III Assembly Organ Growth Regulation Of Growth Negative Regulation Of Multicellular Organism Growth Negative Regulation Of Apoptotic Process [2Fe-2S] Cluster Assembly [4Fe-4S] Cluster Assembly Negative Regulation Of Organ Growth Muscle Cell Cellular Homeostasis Positive Regulation Of Lyase Activity Protein Maturation Cellular Response To Hydrogen Peroxide Negative Regulation Of Release Of Cytochrome C From Mitochondria Inorganic Ion Homeostasis
Pathways		Mitochondrial protein import Mitochondrial protein import Mitochondrial iron-sulfur cluster biogenesis Maturation of TCA enzymes and regulation of TCA cycle Complex III assembly
Drugs		Iron Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate
Diseases		Friedreich ataxia
GWAS		Headache ( 29397368) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Myopia ( 27182965) Night sleep phenotypes ( 27126917) Refractive error ( 32231278) Seasonality ( 25562672)
Novel Interacting Genes		1 novel interacting genes: GGCX
Interacting Genes		7 interacting genes: ACTN1 AKT1 DAPP1 GOLGA6L9 PICK1 PMPCB RNF126
Entrez ID		2395
HPRD ID		06013
Ensembl ID		ENSG00000165060
Uniprot IDs		A0A0S2Z3G4 Q16595
PDB IDs		1EKG 1LY7 3S4M 3S5D 3S5E 3S5F 3T3J 3T3K 3T3L 3T3T 3T3X 5KZ5 6NZU 8PK8 8PK9 8RME
Enriched GO Terms of Interacting Partners?		Protein K29-linked Ubiquitination Mitochondrial Calcium Ion Transmembrane Transport Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Postsynapse Organization Platelet Morphogenesis Structural Constituent Of Postsynapse Protein Modification Process Positive Regulation Of Protein Localization To Endoplasmic Reticulum Response To Insulin-like Growth Factor Stimulus Protein Metabolic Process Protein Maturation Mammalian Oogenesis Stage Regulation Of Ketone Metabolic Process Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Negative Regulation Of Small Molecule Metabolic Process TRNA (guanine-N7)-methylation Regulation Of Steroid Biosynthetic Process Negative Regulation Of Lipid Metabolic Process TORC2 Complex Binding Cellular Response To Rapamycin Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Deoxyribonuclease Activity Negative Regulation Of Protein Localization To Lysosome Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Regulation Of TRNA Methylation Positive Regulation Of Endodeoxyribonuclease Activity Regulation Of Steroid Metabolic Process SREBP-SCAP Complex Retention In Endoplasmic Reticulum Vitamin Binding Gamma-glutamyl Carboxylase Activity Negative Regulation Of Bone Development Negative Regulation Of Testosterone Biosynthetic Process Phospholipid Binding Membrane Curvature Sensor Activity Protein Processing Involved In Protein Targeting To Mitochondrion Mitochondrial Processing Peptidase Complex Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System Cytoplasm Protein Quality Control Cellular Response To Decreased Oxygen Levels Actin Filament Binding Fascia Adherens Actin Filament Network Formation Response To Rapamycin Cellular Response To Oxygen Levels Nitric-oxide Synthase Regulator Activity Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Negative Regulation Of SREBP Signaling Pathway Calcium Ion Transmembrane Transport Negative Regulation Of Fatty Acid Beta-oxidation
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