FXN and PICK1

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		FXN	PICK1
Gene Name		frataxin	protein interacting with PRKCA 1
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Cytosol	Cytoplasm Mitochondrion Golgi Apparatus Cytoskeleton Plasma Membrane Cell Junction Endocytic Vesicle Membrane Presynaptic Membrane Neuron Projection Synapse Postsynaptic Membrane Perinuclear Region Of Cytoplasm Neuronal Postsynaptic Density
	Molecular Function	Ferroxidase Activity Protein Binding Ferrous Iron Binding Ferric Iron Binding Iron Chaperone Activity Iron-sulfur Cluster Binding 2 Iron, 2 Sulfur Cluster Binding	G-protein Coupled Receptor Binding Protein Kinase C Binding Receptor Binding Protein Binding Protein C-terminus Binding ATPase Activity Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Metal Ion Binding Actin Filament Binding Arp2/3 Complex Binding
	Biological Process	Oxidative Phosphorylation Heme Biosynthetic Process Ion Transport Cellular Iron Ion Homeostasis Mitochondrion Organization Adult Walking Behavior Positive Regulation Of Cell Proliferation Aerobic Respiration Embryo Development Ending In Birth Or Egg Hatching Response To Iron Ion Regulation Of Ferrochelatase Activity Protein Autoprocessing Iron Incorporation Into Metallo-sulfur Cluster Proprioception Positive Regulation Of Cell Growth Negative Regulation Of Multicellular Organism Growth Negative Regulation Of Apoptotic Process Small Molecule Metabolic Process Negative Regulation Of Organ Growth Positive Regulation Of Metalloenzyme Activity Positive Regulation Of Transferase Activity Positive Regulation Of Lyase Activity Positive Regulation Of Oxidoreductase Activity Cellular Response To Hydrogen Peroxide Negative Regulation Of Release Of Cytochrome C From Mitochondria	Positive Regulation Of Receptor Internalization Protein Phosphorylation Protein Targeting Retrograde Vesicle-mediated Transport, Golgi To ER Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Synaptic Transmission Monoamine Transport Glial Cell Development Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cellular Response To Decreased Oxygen Levels Cellular Response To Glucose Starvation DNA Methylation Involved In Embryo Development DNA Methylation Involved In Gamete Generation Receptor Clustering Neuronal Ion Channel Clustering Long Term Synaptic Depression Dendritic Spine Organization Dendritic Spine Maintenance
Pathways		Mitochondrial iron-sulfur cluster biogenesis Mitochondrial protein import	Trafficking of GluR2-containing AMPA receptors Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Trafficking of AMPA receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Transmission across Chemical Synapses
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: ACTN1 PICK1 PMPCB	47 interactors: APTX AQP1 ARF1 ARF3 ASIC1 ASIC2 ATXN1L ATXN3 ATXN7 ATXN7L3 BTG2 CIC COIL CTNNB1 EFNB1 EFNB2 EHD2 EPHB2 ERBB2 ERBB2IP F11R FXN GFI1 GFI1B GRIA1 GRIA2 GRIA3 GRIA4 GRIK1 GRIK2 GRIK3 GRIP1 GRM3 GRM7 JAM3 LRP2BP MLLT4 PARK2 PRKCA PRKCG PRLHR PVRL2 PVRL4 SACS SLC6A3 UBQLN4 USP7
Entrez ID		2395	9463
HPRD ID		06013	16176
Ensembl ID		ENSG00000165060	ENSG00000100151
Uniprot IDs		Q16595	B3KS52 Q9NRD5
PDB IDs		1EKG 1LY7 3S4M 3S5D 3S5E 3S5F 3T3J 3T3K 3T3L 3T3T 3T3X	2GZV
Enriched GO Terms of Interacting Partners?		Protein Localization To Tight Junction Protein Localization Establishment Of Localization In Cell DNA Methylation Involved In Embryo Development Protein Targeting Protein Localization To Cell Junction Cellular Localization Dendritic Spine Maintenance Neuronal Ion Channel Clustering Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Negative Regulation Of Actin Nucleation Long Term Synaptic Depression Actin Crosslink Formation Positive Regulation Of Receptor Internalization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Dendritic Spine Organization DNA Methylation Involved In Gamete Generation Regulation Of Actin Nucleation Cellular Response To Glucose Starvation Monoamine Transport Cellular Component Maintenance Neuron Maturation Regulation Of Receptor Internalization Focal Adhesion Assembly Intracellular Protein Transport Retrograde Vesicle-mediated Transport, Golgi To ER Positive Regulation Of Receptor-mediated Endocytosis Adherens Junction Assembly Tight Junction Assembly Cell-substrate Junction Assembly Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Receptor Clustering DNA Methylation Negative Regulation Of Synaptic Transmission Actin Filament Bundle Assembly Protein Targeting To Mitochondrion Platelet Degranulation Apical Junction Assembly Protein Localization To Mitochondrion Transport Cellular Protein Localization Protein Transport Vesicle-mediated Transport DNA Modification Adherens Junction Organization Establishment Of Protein Localization Intracellular Transport Cellular Response To Decreased Oxygen Levels Glial Cell Development Positive Regulation Of Endocytosis	Cell-cell Signaling Synaptic Transmission Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Neuron-neuron Synaptic Transmission Cellular Response To Stimulus Regulation Of Cellular Process Response To Stimulus Signaling Cell Communication Behavior Regulation Of Synaptic Transmission Single-organism Behavior Neurological System Process Negative Regulation Of Synaptic Transmission Regulation Of Synaptic Transmission, Glutamatergic Signal Transduction Adenylate Cyclase-inhibiting G-protein Coupled Glutamate Receptor Signaling Pathway Anatomical Structure Development Cell Surface Receptor Signaling Pathway Regulation Of Cellular Component Organization Nervous System Development Negative Regulation Of Synaptic Transmission, Glutamatergic Cell Junction Assembly Developmental Process Ion Transport Cell-cell Junction Organization Ion Transmembrane Transport G-protein Coupled Glutamate Receptor Signaling Pathway Histone Deubiquitination Learning Or Memory Negative Regulation Of Adenylate Cyclase Activity Multicellular Organismal Development Regulation Of Body Fluid Levels Negative Regulation Of Lyase Activity Establishment Of Endothelial Barrier Cognition Response To External Stimulus System Development Regulation Of Signaling Adherens Junction Organization Multicellular Organismal Response To Stress Negative Regulation Of CAMP Biosynthetic Process Cellular Process Negative Regulation Of CAMP Metabolic Process Sensory Perception Of Sour Taste Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Death Negative Regulation Of Programmed Cell Death
Tagcloud ?		astrocyte astrocytes ataxia autonomous biogenesis conditioned detrimental drives fa frataxin friedreich gaa glia homozygous intron lentivirus manifestations neurite neurodegenerative provoked recessive shrna shrna37 sulfur superoxide take transduced ubiquitous underlining	altering ampa calsyntenin clarified confirming coordinated deprivation elicited excitotoxic glua1 glun2a glun2b glun3a grip1 hippocampal insults ionotropic ischemia ogd profound proteome repression sapap2 snap submitted synaptic tarpgamma3 transcriptome vulnerability
Tagcloud (Difference) ?		astrocyte astrocytes ataxia autonomous biogenesis conditioned detrimental drives fa frataxin friedreich gaa glia homozygous intron lentivirus manifestations neurite neurodegenerative provoked recessive shrna shrna37 sulfur superoxide take transduced ubiquitous underlining	altering ampa calsyntenin clarified confirming coordinated deprivation elicited excitotoxic glua1 glun2a glun2b glun3a grip1 hippocampal insults ionotropic ischemia ogd profound proteome repression sapap2 snap submitted synaptic tarpgamma3 transcriptome vulnerability
Tagcloud (Intersection) ?