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XRN2 and EXOSC8
Number of citations of the paper that reports this interaction (PMID
15231747
)
44
Data Source:
HPRD
(two hybrid)
XRN2
EXOSC8
Gene Name
5-3 exoribonuclease 2
exosome component 8
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleolus
Membrane
Aggresome
Exosome (RNase Complex)
Nucleus
Nucleolus
Cytoplasm
Cytosol
Molecular Function
Transcription Termination Site Sequence-specific DNA Binding
Nuclease Activity
5'-3' Exoribonuclease Activity
Zinc Ion Binding
5'-3' Exonuclease Activity
Poly(A) RNA Binding
Exoribonuclease Activity
Protein Binding
AU-rich Element Binding
Biological Process
DNA Catabolic Process, Exonucleolytic
DNA-templated Transcription, Termination
Regulation Of Transcription, DNA-templated
RNA Processing
MRNA Processing
RNA Catabolic Process
Spermatogenesis
Cell Growth
RNA Metabolic Process
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
RRNA Processing
Biological_process
Gene Expression
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Pathways
Protein folding
Chaperonin-mediated protein folding
Association of TriC/CCT with target proteins during biosynthesis
Regulation of mRNA stability by proteins that bind AU-rich elements
KSRP destabilizes mRNA
mRNA decay by 3' to 5' exoribonuclease
ATF4 activates genes
Tristetraprolin (TTP) destabilizes mRNA
PERK regulates gene expression
Unfolded Protein Response (UPR)
Deadenylation-dependent mRNA decay
Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Protein-Protein Interactions
24 interactors:
ALDH1B1
ATRN
COMT
CSNK2A1
CTSC
DISC1
DXO
EEF1A1
EIF3L
EIF5A
EIF6
ERG
EXOSC10
EXOSC8
LSM3
MOCS3
MRPL4
MRPS10
PRAME
PSMA3
TARDBP
TIPARP
TOLLIP
UPF2
42 interactors:
AEN
ATF2
COL23A1
COX5A
CRMP1
CWC22
DIS3
DUSP23
EXOSC1
EXOSC10
EXOSC2
EXOSC3
EXOSC4
EXOSC5
EXOSC6
EXOSC7
EXOSC9
FAM90A1
FHOD1
FOXN3
FRG1
LSM1
LSM7
MKRN1
MORN4
MPP6
OTUD4
RASSF1
REL
RPP14
SKIV2L2
SNRPC
TCEA2
TFAP4
TXNDC17
TXNDC9
UBC
UPF2
USP6
XRN1
XRN2
ZFP36
Entrez ID
22803
11340
HPRD ID
10309
09351
Ensembl ID
ENSG00000088930
ENSG00000120699
Uniprot IDs
Q9H0D6
Q96B26
PDB IDs
2NN6
Enriched GO Terms of Interacting Partners
?
Gene Expression
Nuclear-transcribed MRNA Catabolic Process
MRNA Catabolic Process
RNA Catabolic Process
Positive Regulation Of Protein Catabolic Process
Aromatic Compound Catabolic Process
MRNA Metabolic Process
Nuclear MRNA Surveillance
Translational Elongation
RNA Surveillance
Catabolic Process
Regulation Of Protein Catabolic Process
Translation
Cellular Metabolic Process
Translational Initiation
RNA Metabolic Process
Positive Regulation Of Protein Metabolic Process
Cellular Macromolecule Catabolic Process
Nitrogen Compound Metabolic Process
Biosynthetic Process
Nuclear Export
Ribonucleoprotein Complex Biogenesis
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Cellular Macromolecule Biosynthetic Process
Metabolic Process
Estrogen Metabolic Process
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic
Macromolecule Biosynthetic Process
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
RNA Localization
Positive Regulation Of Cellular Protein Catabolic Process
Positive Regulation Of Wnt Signaling Pathway
Ribosome Biogenesis
Regulation Of Protein Metabolic Process
Cellular Aromatic Compound Metabolic Process
Posttranscriptional Regulation Of Gene Expression
Positive Regulation Of Homocysteine Metabolic Process
TRNA Wobble Position Uridine Thiolation
Enzyme Active Site Formation Via L-cysteine Persulfide
Cellular Response To Phosphate Starvation
Negative Regulation Of Potassium Ion Export
Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Cellular Nitrogen Compound Metabolic Process
Regulation Of Metabolic Process
Regulation Of RNA Stability
Cellular Protein Metabolic Process
Regulation Of Homocysteine Metabolic Process
Protein Adenylylation
Regulation Of Heart Rate By Hormone
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
RNA Catabolic Process
Nuclear-transcribed MRNA Catabolic Process
MRNA Catabolic Process
MRNA Metabolic Process
RRNA Metabolic Process
RRNA Processing
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Ribosome Biogenesis
Aromatic Compound Catabolic Process
Nuclear MRNA Surveillance
Ribonucleoprotein Complex Biogenesis
RNA Metabolic Process
Cellular Macromolecule Catabolic Process
NcRNA Metabolic Process
RNA Surveillance
RNA Phosphodiester Bond Hydrolysis
RRNA Catabolic Process
Nucleobase-containing Compound Metabolic Process
Nucleic Acid Phosphodiester Bond Hydrolysis
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Maturation Of 5.8S RRNA
Gene Expression
Cellular Nitrogen Compound Metabolic Process
Catabolic Process
Nitrogen Compound Metabolic Process
Nuclear Polyadenylation-dependent RRNA Catabolic Process
CUT Catabolic Process
DNA Deamination
Histone MRNA Catabolic Process
RNA Processing
Cellular Metabolic Process
Histone MRNA Metabolic Process
MRNA Processing
Intracellular MRNA Localization
Metabolic Process
Nuclear Polyadenylation-dependent TRNA Catabolic Process
Polyadenylation-dependent SnoRNA 3'-end Processing
Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription
U4 SnRNA 3'-end Processing
TRNA Catabolic Process
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5'
DNA Modification
Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
RNA Splicing
SnoRNA Metabolic Process
RNA Splicing, Via Transesterification Reactions
Tagcloud
?
8s
arabidopsis
at1g52930
at3g15460
atbrx1
biogenesis
brx1
bypassed
ets
eukaryotes
export
implying
intermediates
its1
leaves
nucleolus
orthologs
plant
pointed
processing
rbfs
ribosomal
ribosome
rrna
spacer
steps
thaliana
transcribed
ubiquitously
Tagcloud (Difference)
?
8s
arabidopsis
at1g52930
at3g15460
atbrx1
biogenesis
brx1
bypassed
ets
eukaryotes
export
implying
intermediates
its1
leaves
nucleolus
orthologs
plant
pointed
processing
rbfs
ribosomal
ribosome
rrna
spacer
steps
thaliana
transcribed
ubiquitously
Tagcloud (Intersection)
?