XRN2 and MOCS3

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		XRN2	MOCS3
Gene Name		5-3 exoribonuclease 2	molybdenum cofactor synthesis 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Membrane Aggresome	Cytosol
	Molecular Function	Transcription Termination Site Sequence-specific DNA Binding Nuclease Activity 5'-3' Exoribonuclease Activity Zinc Ion Binding 5'-3' Exonuclease Activity Poly(A) RNA Binding	Thiosulfate Sulfurtransferase Activity Protein Binding ATP Binding Nucleotidyltransferase Activity Sulfurtransferase Activity URM1 Activating Enzyme Activity Metal Ion Binding Molybdopterin-synthase Sulfurtransferase Activity Molybdopterin-synthase Adenylyltransferase Activity Protein Adenylyltransferase Activity
	Biological Process	DNA Catabolic Process, Exonucleolytic DNA-templated Transcription, Termination Regulation Of Transcription, DNA-templated RNA Processing MRNA Processing RNA Catabolic Process Spermatogenesis Cell Growth RNA Metabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	TRNA Wobble Uridine Modification TRNA Wobble Position Uridine Thiolation Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Mo-molybdopterin Cofactor Biosynthetic Process Protein Adenylylation Enzyme Active Site Formation Via L-cysteine Persulfide Molybdopterin Cofactor Biosynthetic Process Protein Urmylation TRNA Thio-modification Small Molecule Metabolic Process
Pathways		Protein folding Chaperonin-mediated protein folding Association of TriC/CCT with target proteins during biosynthesis	Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective GIF causes intrinsic factor deficiency Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MMAA causes methylmalonic aciduria type cblA Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective CUBN causes hereditary megaloblastic anemia 1 Molybdenum cofactor biosynthesis Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Defects in vitamin and cofactor metabolism Defects in cobalamin (B12) metabolism
Drugs
Diseases
GWAS
Protein-Protein Interactions		24 interactors: ALDH1B1 ATRN COMT CSNK2A1 CTSC DISC1 DXO EEF1A1 EIF3L EIF5A EIF6 ERG EXOSC10 EXOSC8 LSM3 MOCS3 MRPL4 MRPS10 PRAME PSMA3 TARDBP TIPARP TOLLIP UPF2	3 interactors: EXOSC6 MOCS2 XRN2
Entrez ID		22803	27304
HPRD ID		10309	10092
Ensembl ID		ENSG00000088930	ENSG00000124217
Uniprot IDs		Q9H0D6	O95396
PDB IDs			3I2V
Enriched GO Terms of Interacting Partners?		Gene Expression Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process Positive Regulation Of Protein Catabolic Process Aromatic Compound Catabolic Process MRNA Metabolic Process Nuclear MRNA Surveillance Translational Elongation RNA Surveillance Catabolic Process Regulation Of Protein Catabolic Process Translation Cellular Metabolic Process Translational Initiation RNA Metabolic Process Positive Regulation Of Protein Metabolic Process Cellular Macromolecule Catabolic Process Nitrogen Compound Metabolic Process Biosynthetic Process Nuclear Export Ribonucleoprotein Complex Biogenesis Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Cellular Macromolecule Biosynthetic Process Metabolic Process Estrogen Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Macromolecule Biosynthetic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process RNA Localization Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Wnt Signaling Pathway Ribosome Biogenesis Regulation Of Protein Metabolic Process Cellular Aromatic Compound Metabolic Process Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Homocysteine Metabolic Process TRNA Wobble Position Uridine Thiolation Enzyme Active Site Formation Via L-cysteine Persulfide Cellular Response To Phosphate Starvation Negative Regulation Of Potassium Ion Export Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Regulation Of RNA Stability Cellular Protein Metabolic Process Regulation Of Homocysteine Metabolic Process Protein Adenylylation Regulation Of Heart Rate By Hormone	RNA Catabolic Process DNA Deamination Aromatic Compound Catabolic Process MRNA Metabolic Process Molybdopterin Cofactor Biosynthetic Process Molybdopterin Cofactor Metabolic Process Mo-molybdopterin Cofactor Biosynthetic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Isotype Switching RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Cellular Macromolecule Catabolic Process DNA Catabolic Process, Exonucleolytic Somatic Recombination Of Immunoglobulin Gene Segments Somatic Diversification Of Immunoglobulins Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response DNA Metabolic Process B Cell Activation Involved In Immune Response Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Immunoglobulin Production Heterocycle Metabolic Process DNA-templated Transcription, Termination Water-soluble Vitamin Metabolic Process DNA Modification Nitrogen Compound Metabolic Process RNA Phosphodiester Bond Hydrolysis Vitamin Metabolic Process RRNA Processing Catabolic Process RRNA Metabolic Process DNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process Cell Growth Coenzyme Biosynthetic Process Leukocyte Activation Involved In Immune Response B Cell Activation MRNA Catabolic Process
Tagcloud ?		8s arabidopsis at1g52930 at3g15460 atbrx1 biogenesis brx1 bypassed ets eukaryotes export implying intermediates its1 leaves nucleolus orthologs plant pointed processing rbfs ribosomal ribosome rrna spacer steps thaliana transcribed ubiquitously	1136a 667inscga aldehyde brazilian catabolism cofactor confirmation deficiencies deterioration detoxification encephalopathy geph homocysteine inborn mocs1 mocs2 molybdenum obtaining oxidase radiologic resembling specialized sulfite sulfur suox tentative turkish uric xanthine
Tagcloud (Difference) ?		8s arabidopsis at1g52930 at3g15460 atbrx1 biogenesis brx1 bypassed ets eukaryotes export implying intermediates its1 leaves nucleolus orthologs plant pointed processing rbfs ribosomal ribosome rrna spacer steps thaliana transcribed ubiquitously	1136a 667inscga aldehyde brazilian catabolism cofactor confirmation deficiencies deterioration detoxification encephalopathy geph homocysteine inborn mocs1 mocs2 molybdenum obtaining oxidase radiologic resembling specialized sulfite sulfur suox tentative turkish uric xanthine
Tagcloud (Intersection) ?