XRN2 and ATRN

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
BioGRID (two hybrid)

		XRN2	ATRN
Description		5'-3' exoribonuclease 2	attractin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Membrane Aggresome	Extracellular Region Extracellular Space Golgi Apparatus Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	3'-5'-RNA Exonuclease Activity Transcription Termination Site Sequence-specific DNA Binding Nucleic Acid Binding DNA Binding RNA Binding Nuclease Activity Exonuclease Activity 5'-3' RNA Exonuclease Activity Protein Binding Zinc Ion Binding 5'-3' Exonuclease Activity Hydrolase Activity Identical Protein Binding Metal Ion Binding	Carbohydrate Binding Signaling Receptor Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process Nucleobase-containing Compound Metabolic Process DNA-templated Transcription Termination RRNA Processing Termination Of RNA Polymerase II Transcription RNA Processing MRNA Processing RNA Catabolic Process Spermatogenesis RNA Metabolic Process Hippocampus Development Neuron Differentiation Retina Development In Camera-type Eye	Inflammatory Response Cerebellum Development Regulation Of Multicellular Organism Growth Myelination Pigmentation
Pathways		Association of TriC/CCT with target proteins during biosynthesis Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
Drugs
Diseases
GWAS		Autism spectrum disorder ( 30804558) Hip circumference adjusted for BMI ( 34021172) Lupus nephritis in systemic lupus erythematosus ( 24925725) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 32888494) Red cell distribution width ( 32888494)	Asthma ( 29273806) Diisocyanate-induced asthma ( 25918132) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Monocyte count ( 32888494) Night sleep phenotypes ( 27126917) Postcentral gyrus volume ( 31530798) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)
Interacting Genes		39 interacting genes: ALDH1B1 APP ATRN CEBPA COMT CRY2 CSNK2A1 CTSC DSCAM DSCR9 DXO DYNLT1 EEF1A1 EIF3L EIF5A EIF6 ERG EXOSC10 EXOSC8 LCN2 LSM3 MOCS3 MRPL4 MRPS10 OGT PLEKHF2 PRAME PSMA3 RNF10 RNF8 TARDBP TIPARP TOLLIP TTC23 TTC3 UPF2 USP16 USP7 YTHDF1	4 interacting genes: COPS5 DYRK1A XRN2 ZNF408
Entrez ID		22803	8455
HPRD ID		10309	04388
Ensembl ID		ENSG00000088930	ENSG00000088812
Uniprot IDs		B4DZC3 Q9H0D6	B4DZ36 O75882
PDB IDs
Enriched GO Terms of Interacting Partners?		Macromolecule Metabolic Process Protein Metabolic Process Macromolecule Catabolic Process Nuclear MRNA Surveillance Catabolic Process Positive Regulation Of Protein Metabolic Process Nuclear-transcribed MRNA Catabolic Process Regulation Of Protein Metabolic Process Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Memory Symbiont-mediated Disruption Of Host Cell PML Body MRNA Catabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Nucleobase-containing Compound Catabolic Process Translation Positive Regulation Of Translational Elongation Regulation Of Protein Catabolic Process Positive Regulation Of Translation Positive Regulation Of Metabolic Process Positive Regulation Of Catabolic Process Response To Blue Light Regulation Of Translation Nuclear RNA Surveillance Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process RNA Surveillance Kinase Binding RNA Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Monoubiquitinated Protein Deubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process RRNA 3'-end Processing Nucleolar Exosome (RNase Complex) Cytosol Regulation Of Translational Elongation TRNA Decay Regulation Of Glycolytic Process Regulation Of Macromolecule Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Regulation Of Proteolysis Double-strand Break Repair Via Nonhomologous End Joining Nucleic Acid Metabolic Process Nucleoplasm Rhythmic Process	Transcription Coactivator Activity Negative Regulation Of Heterochromatin Formation Regulation Of Neurofibrillary Tangle Assembly Splicing Factor Binding Histone H3T45 Kinase Activity Exosomal Secretion Macrophage Migration Inhibitory Factor Binding DeNEDDylase Activity Transcription Termination Site Sequence-specific DNA Binding Termination Of RNA Polymerase II Transcription 5'-3' RNA Exonuclease Activity RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Neurofilament Regulation Of Heterochromatin Formation Protein Deneddylation 5'-3' Exonuclease Activity Metal-dependent Deubiquitinase Activity Negative Regulation Of Microtubule Polymerization Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Eukaryotic Translation Initiation Factor 3 Complex Tau-protein Kinase Activity Regulation Of Cellular Response To Stress Negative Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Chromatin Organization Regulation Of Gene Expression Regulation Of Inclusion Body Assembly Identical Protein Binding Regulation Of Protein Neddylation Regulation Of IRE1-mediated Unfolded Protein Response Protein Neddylation DNA-templated Transcription Termination Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Splicing Protein Serine/threonine/tyrosine Kinase Activity
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