XRN2 and EIF5A

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
HPRD (two hybrid)

		XRN2	EIF5A
Gene Name		5-3 exoribonuclease 2	eukaryotic translation initiation factor 5A
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Membrane Aggresome	Nucleus Annulate Lamellae Nuclear Pore Cytoplasm Endoplasmic Reticulum Membrane Cytosol Membrane Extracellular Vesicular Exosome
	Molecular Function	Transcription Termination Site Sequence-specific DNA Binding Nuclease Activity 5'-3' Exoribonuclease Activity Zinc Ion Binding 5'-3' Exonuclease Activity Poly(A) RNA Binding	RNA Binding Translation Elongation Factor Activity Protein Binding U6 SnRNA Binding Ribosome Binding Poly(A) RNA Binding Protein N-terminus Binding
	Biological Process	DNA Catabolic Process, Exonucleolytic DNA-templated Transcription, Termination Regulation Of Transcription, DNA-templated RNA Processing MRNA Processing RNA Catabolic Process Spermatogenesis Cell Growth RNA Metabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	MRNA Export From Nucleus Translational Frameshifting Protein Export From Nucleus Nucleocytoplasmic Transport Apoptotic Process Positive Regulation Of Cell Proliferation Peptidyl-lysine Modification To Peptidyl-hypusine Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Translational Elongation Positive Regulation Of Translational Termination
Pathways		Protein folding Chaperonin-mediated protein folding Association of TriC/CCT with target proteins during biosynthesis	Post-translational protein modification Hypusine synthesis from eIF5A-lysine Gamma carboxylation, hypusine formation and arylsulfatase activation
Drugs
Diseases
GWAS
Protein-Protein Interactions		24 interactors: ALDH1B1 ATRN COMT CSNK2A1 CTSC DISC1 DXO EEF1A1 EIF3L EIF5A EIF6 ERG EXOSC10 EXOSC8 LSM3 MOCS3 MRPL4 MRPS10 PRAME PSMA3 TARDBP TIPARP TOLLIP UPF2	11 interactors: CRX DHPS DOHH MEOX2 REL RPL5 STUB1 TGM2 XPO1 XPO4 XRN2
Entrez ID		22803	1984
HPRD ID		10309	02555
Ensembl ID		ENSG00000088930	ENSG00000132507
Uniprot IDs		Q9H0D6	P63241
PDB IDs			1FH4 3CPF
Enriched GO Terms of Interacting Partners?		Gene Expression Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process Positive Regulation Of Protein Catabolic Process Aromatic Compound Catabolic Process MRNA Metabolic Process Nuclear MRNA Surveillance Translational Elongation RNA Surveillance Catabolic Process Regulation Of Protein Catabolic Process Translation Cellular Metabolic Process Translational Initiation RNA Metabolic Process Positive Regulation Of Protein Metabolic Process Cellular Macromolecule Catabolic Process Nitrogen Compound Metabolic Process Biosynthetic Process Nuclear Export Ribonucleoprotein Complex Biogenesis Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Cellular Macromolecule Biosynthetic Process Metabolic Process Estrogen Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Macromolecule Biosynthetic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process RNA Localization Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Wnt Signaling Pathway Ribosome Biogenesis Regulation Of Protein Metabolic Process Cellular Aromatic Compound Metabolic Process Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Homocysteine Metabolic Process TRNA Wobble Position Uridine Thiolation Enzyme Active Site Formation Via L-cysteine Persulfide Cellular Response To Phosphate Starvation Negative Regulation Of Potassium Ion Export Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Regulation Of RNA Stability Cellular Protein Metabolic Process Regulation Of Homocysteine Metabolic Process Protein Adenylylation Regulation Of Heart Rate By Hormone	Peptidyl-lysine Modification To Peptidyl-hypusine Gene Expression Regulation Of Protein Export From Nucleus Peptidyl-lysine Modification Deoxyhypusine Biosynthetic Process From Spermidine Positive Regulation Of Photoreceptor Cell Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Chaperone-mediated Protein Complex Assembly Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Spermidine Catabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Ribosomal Small Subunit Export From Nucleus Transforming Growth Factor Beta Receptor Signaling Pathway Biosynthetic Process Polyamine Catabolic Process Somite Specification Salivary Gland Cavitation Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Macromolecule Biosynthetic Process Ubiquitin-dependent SMAD Protein Catabolic Process RNA Catabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Ribosome Biogenesis Viral Life Cycle Response To Transforming Growth Factor Beta Ribosomal Large Subunit Export From Nucleus Post-translational Protein Modification Positive Regulation Of Mitochondrial Calcium Ion Concentration Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Regulation Of Nucleocytoplasmic Transport Ribosomal Subunit Export From Nucleus Nitrogen Compound Metabolic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Interleukin-12 Biosynthetic Process Regulation Of Glucocorticoid Metabolic Process Protein Homooligomerization Regulation Of Intracellular Protein Transport Cellular Macromolecule Catabolic Process Transcription From RNA Polymerase II Promoter Misfolded Or Incompletely Synthesized Protein Catabolic Process Positive Regulation Of Protein Export From Nucleus Cellular Response To Misfolded Protein Catabolic Process
Tagcloud ?		8s arabidopsis at1g52930 at3g15460 atbrx1 biogenesis brx1 bypassed ets eukaryotes export implying intermediates its1 leaves nucleolus orthologs plant pointed processing rbfs ribosomal ribosome rrna spacer steps thaliana transcribed ubiquitously	abundant antisense approaching beginning broader cdnas cloning considerably coordinated coordinately determining eif2 eif2b eif4a eif4f emerging focuses generates initiation insight investigators machinery manipulate moderately polypeptides preferential probes repression ribosomes
Tagcloud (Difference) ?		8s arabidopsis at1g52930 at3g15460 atbrx1 biogenesis brx1 bypassed ets eukaryotes export implying intermediates its1 leaves nucleolus orthologs plant pointed processing rbfs ribosomal ribosome rrna spacer steps thaliana transcribed ubiquitously	abundant antisense approaching beginning broader cdnas cloning considerably coordinated coordinately determining eif2 eif2b eif4a eif4f emerging focuses generates initiation insight investigators machinery manipulate moderately polypeptides preferential probes repression ribosomes
Tagcloud (Intersection) ?