XRN2 and PRAME

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
BioGRID (two hybrid)

		XRN2	PRAME
Gene Name		5-3 exoribonuclease 2	preferentially expressed antigen in melanoma
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Membrane Aggresome	Nucleus Plasma Membrane
	Molecular Function	Transcription Termination Site Sequence-specific DNA Binding Nuclease Activity 5'-3' Exoribonuclease Activity Zinc Ion Binding 5'-3' Exonuclease Activity Poly(A) RNA Binding	Protein Binding Retinoic Acid Receptor Binding
	Biological Process	DNA Catabolic Process, Exonucleolytic DNA-templated Transcription, Termination Regulation Of Transcription, DNA-templated RNA Processing MRNA Processing RNA Catabolic Process Spermatogenesis Cell Growth RNA Metabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Transcription, DNA-templated Apoptotic Process Positive Regulation Of Cell Proliferation Cell Differentiation Regulation Of Growth Negative Regulation Of Apoptotic Process Negative Regulation Of Cell Differentiation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Retinoic Acid Receptor Signaling Pathway
Pathways		Protein folding Chaperonin-mediated protein folding Association of TriC/CCT with target proteins during biosynthesis
Drugs
Diseases
GWAS
Protein-Protein Interactions		24 interactors: ALDH1B1 ATRN COMT CSNK2A1 CTSC DISC1 DXO EEF1A1 EIF3L EIF5A EIF6 ERG EXOSC10 EXOSC8 LSM3 MOCS3 MRPL4 MRPS10 PRAME PSMA3 TARDBP TIPARP TOLLIP UPF2	9 interactors: CUL2 RARA RBX1 STK19 TCEB1 TCEB2 UBC XRN2 ZNF408
Entrez ID		22803	23532
HPRD ID		10309	05820
Ensembl ID		ENSG00000088930	ENSG00000185686
Uniprot IDs		Q9H0D6	F5H4B1 P78395
PDB IDs
Enriched GO Terms of Interacting Partners?		Gene Expression Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process Positive Regulation Of Protein Catabolic Process Aromatic Compound Catabolic Process MRNA Metabolic Process Nuclear MRNA Surveillance Translational Elongation RNA Surveillance Catabolic Process Regulation Of Protein Catabolic Process Translation Cellular Metabolic Process Translational Initiation RNA Metabolic Process Positive Regulation Of Protein Metabolic Process Cellular Macromolecule Catabolic Process Nitrogen Compound Metabolic Process Biosynthetic Process Nuclear Export Ribonucleoprotein Complex Biogenesis Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Cellular Macromolecule Biosynthetic Process Metabolic Process Estrogen Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Macromolecule Biosynthetic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process RNA Localization Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Wnt Signaling Pathway Ribosome Biogenesis Regulation Of Protein Metabolic Process Cellular Aromatic Compound Metabolic Process Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Homocysteine Metabolic Process TRNA Wobble Position Uridine Thiolation Enzyme Active Site Formation Via L-cysteine Persulfide Cellular Response To Phosphate Starvation Negative Regulation Of Potassium Ion Export Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Regulation Of RNA Stability Cellular Protein Metabolic Process Regulation Of Homocysteine Metabolic Process Protein Adenylylation Regulation Of Heart Rate By Hormone	Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Response To Hypoxia Viral Process Cellular Macromolecule Catabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Response To Abiotic Stimulus Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Transcription, DNA-templated RNA Biosynthetic Process Cellular Response To Stress Positive Regulation Of Viral Transcription Cellular Protein Metabolic Process Transcription From RNA Polymerase II Promoter Catabolic Process Transcription Elongation From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Regulation Of Viral Transcription Positive Regulation Of Viral Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Cellular Protein Modification Process Sertoli Cell Fate Commitment DNA-templated Transcription, Elongation Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Gene Expression Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Protein Metabolic Process Notch Signaling Pathway
Tagcloud ?		8s arabidopsis at1g52930 at3g15460 atbrx1 biogenesis brx1 bypassed ets eukaryotes export implying intermediates its1 leaves nucleolus orthologs plant pointed processing rbfs ribosomal ribosome rrna spacer steps thaliana transcribed ubiquitously	aberrantly acetylglucosaminyltransferase antigens bage ctl ecto fig fm3 fm57 gage gp100 immunogenic immunogenicity in4 maa mage mart melan melanocyte melanomas p15 pbl permitted pointing ref tab trp tyrosinase uncloned
Tagcloud (Difference) ?		8s arabidopsis at1g52930 at3g15460 atbrx1 biogenesis brx1 bypassed ets eukaryotes export implying intermediates its1 leaves nucleolus orthologs plant pointed processing rbfs ribosomal ribosome rrna spacer steps thaliana transcribed ubiquitously	aberrantly acetylglucosaminyltransferase antigens bage ctl ecto fig fm3 fm57 gage gp100 immunogenic immunogenicity in4 maa mage mart melan melanocyte melanomas p15 pbl permitted pointing ref tab trp tyrosinase uncloned
Tagcloud (Intersection) ?