XRN2 and PRAME

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
BioGRID (two hybrid)

		XRN2	PRAME
Description		5'-3' exoribonuclease 2	PRAME nuclear receptor transcriptional regulator
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Membrane Aggresome	Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Golgi Apparatus Plasma Membrane Membrane Cul2-RING Ubiquitin Ligase Complex
	Molecular Function	3'-5'-RNA Exonuclease Activity Transcription Termination Site Sequence-specific DNA Binding Nucleic Acid Binding DNA Binding RNA Binding Nuclease Activity Exonuclease Activity 5'-3' RNA Exonuclease Activity Protein Binding Zinc Ion Binding 5'-3' Exonuclease Activity Hydrolase Activity Identical Protein Binding Metal Ion Binding	Protein Binding Nuclear Retinoic Acid Receptor Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process Nucleobase-containing Compound Metabolic Process DNA-templated Transcription Termination RRNA Processing Termination Of RNA Polymerase II Transcription RNA Processing MRNA Processing RNA Catabolic Process Spermatogenesis RNA Metabolic Process Hippocampus Development Neuron Differentiation Retina Development In Camera-type Eye	Protein Polyubiquitination Apoptotic Process Positive Regulation Of Cell Population Proliferation Protein Ubiquitination Cell Differentiation Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Differentiation Negative Regulation Of DNA-templated Transcription Negative Regulation Of Retinoic Acid Receptor Signaling Pathway
Pathways		Association of TriC/CCT with target proteins during biosynthesis Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
Drugs
Diseases
GWAS		Autism spectrum disorder ( 30804558) Hip circumference adjusted for BMI ( 34021172) Lupus nephritis in systemic lupus erythematosus ( 24925725) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 32888494) Red cell distribution width ( 32888494)
Interacting Genes		39 interacting genes: ALDH1B1 APP ATRN CEBPA COMT CRY2 CSNK2A1 CTSC DSCAM DSCR9 DXO DYNLT1 EEF1A1 EIF3L EIF5A EIF6 ERG EXOSC10 EXOSC8 LCN2 LSM3 MOCS3 MRPL4 MRPS10 OGT PLEKHF2 PRAME PSMA3 RNF10 RNF8 TARDBP TIPARP TOLLIP TTC23 TTC3 UPF2 USP16 USP7 YTHDF1	9 interacting genes: ELOB ELOC FBXO7 RARA RBX1 UBC WHR1 XRN2 ZNF408
Entrez ID		22803	23532
HPRD ID		10309	05820
Ensembl ID		ENSG00000088930	ENSG00000185686
Uniprot IDs		B4DZC3 Q9H0D6	B7Z7K8 B7Z986 B7ZAT0 P78395
PDB IDs
Enriched GO Terms of Interacting Partners?		Macromolecule Metabolic Process Protein Metabolic Process Macromolecule Catabolic Process Nuclear MRNA Surveillance Catabolic Process Positive Regulation Of Protein Metabolic Process Nuclear-transcribed MRNA Catabolic Process Regulation Of Protein Metabolic Process Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Memory Symbiont-mediated Disruption Of Host Cell PML Body MRNA Catabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Nucleobase-containing Compound Catabolic Process Translation Positive Regulation Of Translational Elongation Regulation Of Protein Catabolic Process Positive Regulation Of Translation Positive Regulation Of Metabolic Process Positive Regulation Of Catabolic Process Response To Blue Light Regulation Of Translation Nuclear RNA Surveillance Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process RNA Surveillance Kinase Binding RNA Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Monoubiquitinated Protein Deubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process RRNA 3'-end Processing Nucleolar Exosome (RNase Complex) Cytosol Regulation Of Translational Elongation TRNA Decay Regulation Of Glycolytic Process Regulation Of Macromolecule Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Regulation Of Proteolysis Double-strand Break Repair Via Nonhomologous End Joining Nucleic Acid Metabolic Process Nucleoplasm Rhythmic Process	Macromolecule Catabolic Process Cul5-RING Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex VCB Complex Target-directed MiRNA Degradation Elongin Complex RNA Catabolic Process Modification-dependent Protein Catabolic Process Catabolic Process Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Binding MiRNA Catabolic Process Ubiquitin Ligase Complex Nucleobase-containing Compound Catabolic Process Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Post-translational Protein Modification Negative Regulation Of MiRNA-mediated Gene Silencing Nucleobase-containing Compound Biosynthetic Process Post-transcriptional Gene Silencing Protein Modification Process MiRNA Metabolic Process Regulation Of MiRNA-mediated Gene Silencing Regulation Of Post-transcriptional Gene Silencing Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Gene Expression Nucleus Proteolysis Nucleic Acid Metabolic Process Post-transcriptional Regulation Of Gene Expression Macromolecule Metabolic Process Transcription Initiation At RNA Polymerase II Promoter Transcription Elongation By RNA Polymerase II Regulation Of Mitophagy Transcription Corepressor Binding Regulation Of Autophagy Of Mitochondrion RNA Metabolic Process DNA-templated Transcription Elongation Macromolecule Biosynthetic Process SCF Ubiquitin Ligase Complex Sertoli Cell Fate Commitment Positive Regulation Of Single Strand Break Repair Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Nucleobase-containing Compound Metabolic Process Hippocampus Development Autophagy Of Mitochondrion
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