XRN2 and TIPARP

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
HPRD (two hybrid)

		XRN2	TIPARP
Description		5'-3' exoribonuclease 2	TCDD inducible poly(ADP-ribose) polymerase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Membrane Aggresome	Nucleus
	Molecular Function	3'-5'-RNA Exonuclease Activity Transcription Termination Site Sequence-specific DNA Binding Nucleic Acid Binding DNA Binding RNA Binding Nuclease Activity Exonuclease Activity 5'-3' RNA Exonuclease Activity Protein Binding Zinc Ion Binding 5'-3' Exonuclease Activity Hydrolase Activity Identical Protein Binding Metal Ion Binding	Cis-regulatory Region Sequence-specific DNA Binding NAD+ Poly-ADP-ribosyltransferase Activity Zinc Ion Binding Transferase Activity Glycosyltransferase Activity Nucleotidyltransferase Activity Metal Ion Binding NAD+-protein-cysteine ADP-ribosyltransferase Activity NAD+-protein-aspartate ADP-ribosyltransferase Activity NAD+-protein-glutamate ADP-ribosyltransferase Activity NAD+-protein Mono-ADP-ribosyltransferase Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process Nucleobase-containing Compound Metabolic Process DNA-templated Transcription Termination RRNA Processing Termination Of RNA Polymerase II Transcription RNA Processing MRNA Processing RNA Catabolic Process Spermatogenesis RNA Metabolic Process Hippocampus Development Neuron Differentiation Retina Development In Camera-type Eye	Vasculogenesis Kidney Development Androgen Metabolic Process Estrogen Metabolic Process Female Gonad Development Post-embryonic Development Negative Regulation Of Gene Expression Hemopoiesis Positive Regulation Of Protein Catabolic Process Platelet-derived Growth Factor Receptor Signaling Pathway Skeletal System Morphogenesis Smooth Muscle Tissue Development Roof Of Mouth Development Face Morphogenesis Response To 2,3,7,8-tetrachlorodibenzodioxine
Pathways		Association of TriC/CCT with target proteins during biosynthesis Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
Drugs
Diseases
GWAS		Autism spectrum disorder ( 30804558) Hip circumference adjusted for BMI ( 34021172) Lupus nephritis in systemic lupus erythematosus ( 24925725) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 32888494) Red cell distribution width ( 32888494)	Adult body size ( 32376654) Central corneal thickness ( 29760442) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Chronotype ( 30696823) Epithelial ovarian cancer ( 25581431) Femur bone mineral density x serum urate levels interaction ( 34046847) Malaria ( 31844061) Nose size ( 27182965) Ovarian cancer ( 20852632) Testicular germ cell tumor ( 28604732) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		39 interacting genes: ALDH1B1 APP ATRN CEBPA COMT CRY2 CSNK2A1 CTSC DSCAM DSCR9 DXO DYNLT1 EEF1A1 EIF3L EIF5A EIF6 ERG EXOSC10 EXOSC8 LCN2 LSM3 MOCS3 MRPL4 MRPS10 OGT PLEKHF2 PRAME PSMA3 RNF10 RNF8 TARDBP TIPARP TOLLIP TTC23 TTC3 UPF2 USP16 USP7 YTHDF1	3 interacting genes: ATM RNF10 XRN2
Entrez ID		22803	25976
HPRD ID		10309	18192
Ensembl ID		ENSG00000088930	ENSG00000163659
Uniprot IDs		B4DZC3 Q9H0D6	Q05BQ2 Q7Z3E1
PDB IDs
Enriched GO Terms of Interacting Partners?		Macromolecule Metabolic Process Protein Metabolic Process Macromolecule Catabolic Process Nuclear MRNA Surveillance Catabolic Process Positive Regulation Of Protein Metabolic Process Nuclear-transcribed MRNA Catabolic Process Regulation Of Protein Metabolic Process Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Memory Symbiont-mediated Disruption Of Host Cell PML Body MRNA Catabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Nucleobase-containing Compound Catabolic Process Translation Positive Regulation Of Translational Elongation Regulation Of Protein Catabolic Process Positive Regulation Of Translation Positive Regulation Of Metabolic Process Positive Regulation Of Catabolic Process Response To Blue Light Regulation Of Translation Nuclear RNA Surveillance Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process RNA Surveillance Kinase Binding RNA Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Monoubiquitinated Protein Deubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process RRNA 3'-end Processing Nucleolar Exosome (RNase Complex) Cytosol Regulation Of Translational Elongation TRNA Decay Regulation Of Glycolytic Process Regulation Of Macromolecule Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Regulation Of Proteolysis Double-strand Break Repair Via Nonhomologous End Joining Nucleic Acid Metabolic Process Nucleoplasm Rhythmic Process	Protein Monoubiquitination Establishment Of RNA Localization To Telomere MRNA Catabolic Process Establishment Of Protein-containing Complex Localization To Telomere RNA Catabolic Process Positive Regulation Of Telomerase Catalytic Core Complex Assembly Macromolecule Catabolic Process Nuclear-transcribed MRNA Catabolic Process Transcription Termination Site Sequence-specific DNA Binding DNA-dependent Protein Kinase Activity Histone H2AXS139 Kinase Activity Cellular Response To Nitrosative Stress Pre-B Cell Allelic Exclusion 5'-3' RNA Exonuclease Activity Peptidyl-serine Autophosphorylation Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Nucleobase-containing Compound Catabolic Process Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Negative Regulation Of Telomere Capping Response To Nitrosative Stress Catabolic Process Negative Regulation Of Schwann Cell Proliferation Termination Of RNA Polymerase II Transcription Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Telomere Localization Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Cellular Response To X-ray 1-phosphatidylinositol-3-kinase Activity 5'-3' Exonuclease Activity DNA Binding Lipoprotein Catabolic Process Ubiquitin-dependent Protein Catabolic Process DNA Repair Complex Female Meiotic Nuclear Division Oocyte Development Modification-dependent Protein Catabolic Process Extrinsic Component Of Synaptic Vesicle Membrane Regulation Of Telomere Capping Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator DNA Strand Resection Involved In Replication Fork Processing Replicative Senescence Pexophagy Regulation Of Cellular Response To Heat Negative Regulation Of B Cell Proliferation Histone MRNA Catabolic Process V(D)J Recombination Gamete Generation Proteasomal Protein Catabolic Process
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