XRN2 and TIPARP

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
HPRD (two hybrid)

		XRN2	TIPARP
Gene Name		5-3 exoribonuclease 2	TCDD-inducible poly(ADP-ribose) polymerase
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Membrane Aggresome	Nucleus
	Molecular Function	Transcription Termination Site Sequence-specific DNA Binding Nuclease Activity 5'-3' Exoribonuclease Activity Zinc Ion Binding 5'-3' Exonuclease Activity Poly(A) RNA Binding	NAD+ ADP-ribosyltransferase Activity Enhancer Binding Metal Ion Binding
	Biological Process	DNA Catabolic Process, Exonucleolytic DNA-templated Transcription, Termination Regulation Of Transcription, DNA-templated RNA Processing MRNA Processing RNA Catabolic Process Spermatogenesis Cell Growth RNA Metabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Vasculogenesis Kidney Development Protein ADP-ribosylation Nitrogen Compound Metabolic Process Androgen Metabolic Process Estrogen Metabolic Process Female Gonad Development Post-embryonic Development Negative Regulation Of Gene Expression Hemopoiesis Multicellular Organismal Metabolic Process Positive Regulation Of Protein Catabolic Process Platelet-derived Growth Factor Receptor Signaling Pathway Skeletal System Morphogenesis Smooth Muscle Tissue Development Palate Development Face Morphogenesis Cellular Response To Organic Cyclic Compound
Pathways		Protein folding Chaperonin-mediated protein folding Association of TriC/CCT with target proteins during biosynthesis
Drugs
Diseases
GWAS			Ovarian cancer ( 20852632)
Protein-Protein Interactions		24 interactors: ALDH1B1 ATRN COMT CSNK2A1 CTSC DISC1 DXO EEF1A1 EIF3L EIF5A EIF6 ERG EXOSC10 EXOSC8 LSM3 MOCS3 MRPL4 MRPS10 PRAME PSMA3 TARDBP TIPARP TOLLIP UPF2	2 interactors: ATM XRN2
Entrez ID		22803	25976
HPRD ID		10309	18192
Ensembl ID		ENSG00000088930	ENSG00000163659
Uniprot IDs		Q9H0D6	Q05BQ2 Q7Z3E1
PDB IDs
Enriched GO Terms of Interacting Partners?		Gene Expression Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process Positive Regulation Of Protein Catabolic Process Aromatic Compound Catabolic Process MRNA Metabolic Process Nuclear MRNA Surveillance Translational Elongation RNA Surveillance Catabolic Process Regulation Of Protein Catabolic Process Translation Cellular Metabolic Process Translational Initiation RNA Metabolic Process Positive Regulation Of Protein Metabolic Process Cellular Macromolecule Catabolic Process Nitrogen Compound Metabolic Process Biosynthetic Process Nuclear Export Ribonucleoprotein Complex Biogenesis Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Cellular Macromolecule Biosynthetic Process Metabolic Process Estrogen Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Macromolecule Biosynthetic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process RNA Localization Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Wnt Signaling Pathway Ribosome Biogenesis Regulation Of Protein Metabolic Process Cellular Aromatic Compound Metabolic Process Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Homocysteine Metabolic Process TRNA Wobble Position Uridine Thiolation Enzyme Active Site Formation Via L-cysteine Persulfide Cellular Response To Phosphate Starvation Negative Regulation Of Potassium Ion Export Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Regulation Of RNA Stability Cellular Protein Metabolic Process Regulation Of Homocysteine Metabolic Process Protein Adenylylation Regulation Of Heart Rate By Hormone	RNA Catabolic Process Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint Aromatic Compound Catabolic Process Pre-B Cell Allelic Exclusion MRNA Metabolic Process Pre-B Cell Differentiation Histone MRNA Catabolic Process Gamete Generation Replicative Senescence Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Immature B Cell Differentiation DNA Damage Induced Protein Phosphorylation Negative Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Sexual Reproduction Lipoprotein Catabolic Process Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Cellular Macromolecule Catabolic Process Positive Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of B Cell Proliferation Mitotic G2 DNA Damage Checkpoint Histone-serine Phosphorylation Cellular Response To Gamma Radiation Histone MRNA Metabolic Process Phosphatidylinositol-3-phosphate Biosynthetic Process Reproduction DNA Metabolic Process V(D)J Recombination Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Cellular Response To Heat RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Single Organism Reproductive Process G2 DNA Damage Checkpoint Mitotic Spindle Assembly Checkpoint DNA Catabolic Process, Exonucleolytic Histone Phosphorylation Spindle Assembly Checkpoint Reproductive Process Negative Regulation Of B Cell Activation Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Oocyte Development Oocyte Differentiation Reciprocal Meiotic Recombination Regulation Of Signal Transduction By P53 Class Mediator Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation
Tagcloud ?		8s arabidopsis at1g52930 at3g15460 atbrx1 biogenesis brx1 bypassed ets eukaryotes export implying intermediates its1 leaves nucleolus orthologs plant pointed processing rbfs ribosomal ribosome rrna spacer steps thaliana transcribed ubiquitously	1a1 acceleration addresses allergen allergenic allergic basophils beas classroom classrooms coagulation cxcl1 cxcl6 cyp cyp1b1 detoxifying endotoxin eu fel hydrocarbons il6 il8 indoor intensified metabolizing outdoor pm polycyclic xenobiotic
Tagcloud (Difference) ?		8s arabidopsis at1g52930 at3g15460 atbrx1 biogenesis brx1 bypassed ets eukaryotes export implying intermediates its1 leaves nucleolus orthologs plant pointed processing rbfs ribosomal ribosome rrna spacer steps thaliana transcribed ubiquitously	1a1 acceleration addresses allergen allergenic allergic basophils beas classroom classrooms coagulation cxcl1 cxcl6 cyp cyp1b1 detoxifying endotoxin eu fel hydrocarbons il6 il8 indoor intensified metabolizing outdoor pm polycyclic xenobiotic
Tagcloud (Intersection) ?