TBC1D1 and MAP1LC3A

Number of citations of the paper that reports this interaction (PMID 22354992)
16

Data Source:
BioGRID (pull down)

		TBC1D1	MAP1LC3A
Gene Name		TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1	microtubule-associated protein 1 light chain 3 alpha
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol	Pre-autophagosomal Structure Autophagic Vacuole Membrane Late Endosome Autophagic Vacuole Cytosol Microtubule Extrinsic Component Of Membrane Organelle Membrane Cytoplasmic Vesicle
	Molecular Function	Rab GTPase Activator Activity Protein Binding	Protein Binding Phospholipid Binding Microtubule Binding Phosphatidylethanolamine Binding GABA Receptor Binding
	Biological Process	Positive Regulation Of Rab GTPase Activity Regulation Of Protein Localization Membrane Organization Regulation Of Cilium Assembly	Autophagic Vacuole Assembly Mitochondrion Degradation Cellular Response To Nitrogen Starvation Nucleophagy Membrane Fusion
Pathways		Translocation of GLUT4 to the plasma membrane
Drugs
Diseases
GWAS		Crohn's disease ( 23266558) Periodontal microbiota ( 22699663)
Protein-Protein Interactions		4 interactors: GABARAPL1 MAP1LC3A SMAD2 YWHAG	40 interactors: AKAP13 APP ATG101 ATG13 ATG3 ATG4B ATG7 BNIP3L DVL2 EPHA7 FAM134C FUNDC1 KIF15 KXD1 MAP1A MAP1S NBR1 OPTN PIAS4 PRPF40A RABGAP1 RABGAP1L RDH12 RTKN SQSTM1 SRPK1 TBC1D1 TBC1D10A TBC1D10B TBC1D16 TBC1D17 TBC1D2 TBC1D25 TBC1D2B TBC1D5 TBC1D7 TBC1D9 TBC1D9B TNIP1 TUBA4A
Entrez ID		23216	84557
HPRD ID		18161	03144
Ensembl ID		ENSG00000065882	ENSG00000101460
Uniprot IDs		B9A6J6 Q6PJJ8 Q86TI0 Q8NC59	Q9H492
PDB IDs		3QYE	3ECI
Enriched GO Terms of Interacting Partners?		Nucleophagy Mitochondrion Degradation Organelle Disassembly Autophagic Vacuole Assembly Macroautophagy Vacuole Organization Membrane Fusion Membrane Organization Cellular Response To Starvation Autophagy Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Cellular Response To Nutrient Levels Response To Starvation Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Zygotic Specification Of Dorsal/ventral Axis Cellular Response To Extracellular Stimulus Positive Regulation Of Mesoderm Development Primary MiRNA Processing Regulation Of Nodal Signaling Pathway Common-partner SMAD Protein Phosphorylation Positive Regulation Of Activin Receptor Signaling Pathway Mitochondrion Organization Response To Nutrient Levels SMAD Protein Complex Assembly Cellular Component Assembly Paraxial Mesoderm Morphogenesis Response To Extracellular Stimulus Organelle Assembly Nodal Signaling Pathway Cellular Response To Nitrogen Starvation Cell Communication Production Of MiRNAs Involved In Gene Silencing By MiRNA Embryonic Foregut Morphogenesis Foregut Morphogenesis Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Paraxial Mesoderm Development Response To Cholesterol Dorsal/ventral Axis Specification Pericardium Development Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Activin Receptor Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition Signal Transduction Involved In Regulation Of Gene Expression Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Gene Silencing By MiRNA Cellular Response To Stimulus Cellular Response To DsRNA Positive Regulation Of BMP Signaling Pathway Insulin Secretion	Positive Regulation Of Rab GTPase Activity Regulation Of Rab GTPase Activity Regulation Of Rab Protein Signal Transduction Autophagy Positive Regulation Of Ras GTPase Activity Regulation Of Ras Protein Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Ras GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of GTPase Activity Regulation Of GTPase Activity Positive Regulation Of Hydrolase Activity Regulation Of Signal Transduction Macroautophagy Response To Starvation Regulation Of Signaling Positive Regulation Of Catalytic Activity Cellular Response To Starvation Cellular Response To Nutrient Levels Regulation Of Catalytic Activity Positive Regulation Of Metabolic Process Cellular Response To Extracellular Stimulus Response To Nutrient Levels Response To Extracellular Stimulus Mitochondrion Degradation Catabolic Process Positive Regulation Of Autophagy Organelle Disassembly Autophagic Vacuole Assembly Regulation Of Metabolic Process Response To External Stimulus Intracellular Transport Retrograde Transport, Endosome To Golgi Nucleophagy Establishment Of Localization In Cell Cellular Localization Endosomal Transport Vacuole Organization Regulation Of Autophagy Cell Death Death Response To Stress Regulation Of Cellular Process Apoptotic Process Programmed Cell Death Organelle Organization Positive Regulation Of Macroautophagy Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cellular Response To Nitrogen Starvation
Tagcloud ?		adaptor alanine appl1 appl2 bar conditional diminishes elusive evoked fine glut4 gtpase homolog hyperglycemia likewise muscles myotubes partner potentiates rab serine skeletal stimulates substitution suppresses suppressive threonine tune uptake	acquiring adenocarcinoma autophagy became came constitutive date demethylation egfr erlotinib escaping exposing gefitinib ie immunoreactivity necessarily neoplastic novo overcoming parental pc9 pivotal predictor pronounced restores tkis treating tumoural
Tagcloud (Difference) ?		adaptor alanine appl1 appl2 bar conditional diminishes elusive evoked fine glut4 gtpase homolog hyperglycemia likewise muscles myotubes partner potentiates rab serine skeletal stimulates substitution suppresses suppressive threonine tune uptake	acquiring adenocarcinoma autophagy became came constitutive date demethylation egfr erlotinib escaping exposing gefitinib ie immunoreactivity necessarily neoplastic novo overcoming parental pc9 pivotal predictor pronounced restores tkis treating tumoural
Tagcloud (Intersection) ?