TBC1D1 and PNKP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TBC1D1	PNKP
Description		TBC1 domain family member 1	polynucleotide kinase 3'-phosphatase
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Golgi Apparatus	Nucleus Nucleoplasm Chromosome Nucleolus Membrane Site Of Double-strand Break
	Molecular Function	GTPase Activator Activity Protein Binding	Nucleotide Binding Damaged DNA Binding Double-stranded DNA Binding Catalytic Activity Endonuclease Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Hydrolase Activity Purine Nucleotide Binding Polynucleotide 3'-phosphatase Activity ATP-dependent Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity ATP-dependent Polynucleotide 5'-hydroxyl-kinase Activity
	Biological Process	Regulation Of Cilium Assembly	DNA-templated DNA Replication DNA Repair Base-excision Repair, Gap-filling Nucleotide-excision Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Damage Response Response To Oxidative Stress Response To Radiation Positive Regulation Of Telomere Maintenance Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane	APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
Drugs
Diseases			Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Amyotrophic lateral sclerosis in C9orf72 mutation negative individuals ( 22959728) Bipolar disorder ( 34099189) Crohn's disease ( 23266558 23850713) Diastolic blood pressure ( 27618452 27841878) Gut microbiota relative abundance (unclassified genus belonging to family Lachnospiraceae) ( 33208821) High-sensitivity cardiac troponin T levels ( 33321125) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Periodontal microbiota ( 22699663) Pulse pressure ( 27841878) Response to antidepressants (symptom remission) ( 29160301) Response to SSRI (symptom remission) ( 29160301) Systolic blood pressure ( 27841878 27618452) Verbal declarative memory ( 25648963) Weight ( 28552196) White blood cell count ( 32888494)
Interacting Genes		31 interacting genes: CALM1 CALM2 CALM3 CCDC185 CWF19L2 EFHC2 FAM161A FAM50B GABARAPL1 GMCL1 HOXC8 HSF2BP HSPB1 KRT75 L3MBTL3 LHX8 LNX1 LZTS1 MAP1LC3A MCRS1 PNKP RIN1 SMAD2 SYTL4 TCEA2 TNNC2 TSGA10IP TXLNA VPS52 YWHAG ZFP1	50 interacting genes: APP CACFD1 CAMK2B CARD10 CCDC14 CISD2 CNTROB COL17A1 DRC4 DVL3 EIF4ENIF1 FADS6 GZMK IKZF1 KANK2 KDM1A KLHL12 KRTAP4-12 LMNA MAGEA11 MCC MEOX2 MGST2 MSANTD4 MYOZ1 OBI1 OGT PICK1 PNMA5 POLB PSTPIP1 RPRM SFT2D1 SMAD5 SNX2 SP4 SUV39H1 SYNGR1 SYNGR3 SYP TARBP2 TBC1D1 THAP1 TMEM239 TNIP1 TRIM37 XRCC1 XRCC4 ZBTB14 ZNF639
Entrez ID		23216	11284
HPRD ID		18161	09284
Ensembl ID		ENSG00000065882	ENSG00000039650
Uniprot IDs		A0A8V8TNS9 B9A6J6 Q6PJJ8 Q86TI0 Q8NC59	Q96T60
PDB IDs		3QYE	2BRF 2W3O
Enriched GO Terms of Interacting Partners?		Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Spindle Microtubule Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Titin Binding Regulation Of Cell Communication By Electrical Coupling Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Detection Of Calcium Ion Protein Phosphatase Activator Activity Calyx Of Held Catalytic Complex Protein Kinase C Inhibitor Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Transporter Activity Calcium Channel Complex Calcineurin-mediated Signaling Presynaptic Cytosol Myelin Sheath Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Cytoskeleton Regulation Of Synaptic Plasticity Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Negative Regulation Of Calcium Ion Transmembrane Transport Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Presynaptic Endocytosis Positive Regulation Of Sequestering Of Calcium Ion Substantia Nigra Development Calcium Channel Regulator Activity Negative Regulation Of Voltage-gated Calcium Channel Activity Sperm Midpiece Negative Regulation Of Calcium Ion Transport G2/M Transition Of Mitotic Cell Cycle Long-term Synaptic Potentiation Sarcomere Cellular Response To Nitrogen Starvation Cell Cycle G2/M Phase Transition Spindle Pole Neural Nucleus Development Adenylate Cyclase Binding Regulation Of Muscle Contraction Negative Regulation Of Cation Transmembrane Transport Calcium Channel Inhibitor Activity Protein Serine/threonine Kinase Activator Activity Phosphatidylethanolamine Binding Vesicle Regulation Of Voltage-gated Calcium Channel Activity	Regulation Of Long-term Neuronal Synaptic Plasticity Protein Binding Identical Protein Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Neuronal Synaptic Plasticity Negative Regulation Of RNA Metabolic Process Synaptic Vesicle Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Enzyme Binding Base-excision Repair Immunoglobulin V(D)J Recombination Regulation Of Synaptic Plasticity Regulation Of Transcription By Glucose Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Cellular Component Organization Regulation Of Synaptic Vesicle Priming Negative Regulation Of Biosynthetic Process Protein Monoubiquitination Negative Regulation Of Macromolecule Metabolic Process Nuclear Lamina Double-strand Break Repair Via Nonhomologous End Joining
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