Wiki-Pi
About
Search
People
Updates
Search
TBC1D1 and SMAD2
Number of citations of the paper that reports this interaction (PubMedID
15231748
)
54
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
TBC1D1
SMAD2
Description
TBC1 domain family member 1
SMAD family member 2
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Golgi Apparatus
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Cytosol
Activin Responsive Factor Complex
Protein-containing Complex
SMAD Protein Complex
Homomeric SMAD Protein Complex
Heteromeric SMAD Protein Complex
Molecular Function
GTPase Activator Activity
Protein Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
Double-stranded DNA Binding
DNA-binding Transcription Factor Activity
Transforming Growth Factor Beta Receptor Binding
Protein Binding
Phosphatase Binding
Ubiquitin Protein Ligase Binding
Type I Transforming Growth Factor Beta Receptor Binding
Identical Protein Binding
SMAD Binding
Metal Ion Binding
Tau Protein Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Co-SMAD Binding
I-SMAD Binding
R-SMAD Binding
Disordered Domain Specific Binding
DNA-binding Transcription Factor Binding
Biological Process
Regulation Of Cilium Assembly
Ureteric Bud Development
In Utero Embryonic Development
Endoderm Formation
Mesoderm Formation
Regionalization
Determination Of Left/right Asymmetry In Lateral Mesoderm
Aortic Valve Morphogenesis
Pulmonary Valve Morphogenesis
Endocardial Cushion Morphogenesis
DNA-templated Transcription
Regulation Of DNA-templated Transcription
Transforming Growth Factor Beta Receptor Signaling Pathway
Zygotic Specification Of Dorsal/ventral Axis
Gastrulation
Pattern Specification Process
Endoderm Development
Mesoderm Development
Heart Development
Cell Population Proliferation
Anatomical Structure Morphogenesis
Response To Glucose
Post-embryonic Development
Embryonic Pattern Specification
Anterior/posterior Pattern Specification
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Epithelial To Mesenchymal Transition
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Insulin Secretion
Cell Differentiation
Negative Regulation Of Ossification
Lung Development
Positive Regulation Of BMP Signaling Pathway
Pancreas Development
Primary MiRNA Processing
Activin Receptor Signaling Pathway
Organ Growth
Intracellular Signal Transduction
Nodal Signaling Pathway
Cell Fate Commitment
Negative Regulation Of Cell Differentiation
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Paraxial Mesoderm Morphogenesis
Developmental Growth
Embryonic Foregut Morphogenesis
Embryonic Cranial Skeleton Morphogenesis
Regulation Of Multicellular Organismal Process
Pericardium Development
SMAD Protein Signal Transduction
Mesenchyme Development
Trophoblast Cell Migration
Secondary Palate Development
Response To Cholesterol
Response To Transforming Growth Factor Beta
Odontoblast Differentiation
Pathways
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Signaling by NODAL
Signaling by NODAL
Signaling by Activin
Signaling by Activin
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling activates SMADs
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
SMAD2/3 Phosphorylation Motif Mutants in Cancer
SMAD4 MH2 Domain Mutants in Cancer
SMAD2/3 MH2 Domain Mutants in Cancer
TGFBR1 KD Mutants in Cancer
Transcriptional regulation of pluripotent stem cells
Ub-specific processing proteases
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
FOXO-mediated transcription of cell cycle genes
FOXO-mediated transcription of cell cycle genes
Germ layer formation at gastrulation
Formation of axial mesoderm
Formation of definitive endoderm
Formation of definitive endoderm
Drugs
Dexfosfoserine
Diseases
Colorectal cancer
GWAS
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Amyotrophic lateral sclerosis in C9orf72 mutation negative individuals (
22959728
)
Bipolar disorder (
34099189
)
Crohn's disease (
23266558
23850713
)
Diastolic blood pressure (
27618452
27841878
)
Gut microbiota relative abundance (unclassified genus belonging to family Lachnospiraceae) (
33208821
)
High-sensitivity cardiac troponin T levels (
33321125
)
Lymphocyte count (
27863252
32888494
)
Lymphocyte percentage of white cells (
27863252
32888494
)
Monocyte percentage of white cells (
32888494
)
Neutrophil percentage of white cells (
32888494
27863252
)
Periodontal microbiota (
22699663
)
Pulse pressure (
27841878
)
Response to antidepressants (symptom remission) (
29160301
)
Response to SSRI (symptom remission) (
29160301
)
Systolic blood pressure (
27841878
27618452
)
Verbal declarative memory (
25648963
)
Weight (
28552196
)
White blood cell count (
32888494
)
Coronary artery disease in type 1 diabetes (
29695241
)
Daytime nap (
33568662
)
Lung cancer in ever smokers (
28604730
)
Menarche (age at onset) (
27182965
)
Interacting Genes
31 interacting genes:
CALM1
CALM2
CALM3
CCDC185
CWF19L2
EFHC2
FAM161A
FAM50B
GABARAPL1
GMCL1
HOXC8
HSF2BP
HSPB1
KRT75
L3MBTL3
LHX8
LNX1
LZTS1
MAP1LC3A
MCRS1
PNKP
RIN1
SMAD2
SYTL4
TCEA2
TNNC2
TSGA10IP
TXLNA
VPS52
YWHAG
ZFP1
220 interacting genes:
ABTB1
ACVR1B
AFDN
AKT1
ANAPC10
ANAPC2
ANK3
ANP32B
ANP32E
ANTXR2
AP1B1
ARFGAP3
ARHGEF6
ARL4D
ATP5ME
AXIN1
BAZ1A
BECN1
BPTF
BRCA1
BTBD2
C22orf46P
CAMK2A
CAMK2G
CDC16
CDC27
CDC40
CDK2
CDK4
CDK8
CDK9
CISH
COPS5
CORO2A
CREBBP
CSH1
CSH2
CSNK1D
CTNNB1
CUL5
CYLC2
CYP11A1
DAB2
DCAF6
DCUN1D1
DENND2B
DNAJB5
DNAJC7
DOCK8
DVL1
DYNC1H1
DYRK1A
E2F4
EEF1A1
EID2
EIF3L
ELAC2
EP300
ERBIN
ESR1
ESR2
FAM161B
FBN2
FBP2
FHL2
FHL3
FOXG1
FOXH1
FOXO3
GATAD2B
GFER
GLI3
GRIPAP1
GSC
GTF2I
HDAC1
HDAC2
HGS
HIPK2
HNF4A
HOXA13
HOXA9
HOXD13
HSD17B3
HUWE1
HYAL2
INSR
IRAK2
ITCH
JUN
KAT2B
KHDRBS1
KPNB1
LAMA5
LATS2
LCK
LEF1
LEMD3
LHX9
LITAF
LMO2
MAP2K1
MAPK1
MAPK3
MAPK8
MAPK9
MECOM
MED15
MED6
MEF2A
MEF2C
MYC
MYOCD
NAGK
NCOA6
NEDD4L
NEDD9
NEFM
NFIA
NFYC
NOTCH4
NUAK2
NUP153
NUP214
OS9
OTUB1
PAK1
PAPOLA
PAPPA
PARD3
PAXIP1
PEX19
PIAS3
PIAS4
PIK3CA
PLIN3
POU2AF1
PPM1A
PPP2R1A
PRKAR1A
PSAP
PSG9
PSMD11
PSMD8
PTMS
RAB34
RAB38
RAN
RANBP6
RANBP9
RARB
RASA1
RASD2
RASL12
RBL1
RHEBL1
RHOA
RHOD
RHOJ
RIT1
RNF123
RNPC3
ROCK1
RPS14
RPS27A
RUNX2
RXRA
SKI
SKIL
SKOR2
SMAD1
SMAD3
SMAD4
SMAD7
SMAD9
SMURF1
SMURF2
SNAPIN
SNIP1
SNRNP70
SNW1
SOD1
SP1
SQSTM1
SRI
ST13
STAG1
STAMBP
STAMBPL1
STRAP
STUB1
SYT1
TBC1D1
TGFBR1
TGFBRAP1
TGIF1
TGM2
TNNT1
TOB1
TP53
TP73
TRIM62
TRMO
TSC2
TUBA1B
UBA52
UBR5
UCHL5
USP9X
WASHC4
XPA
YY1
ZEB1
ZEB2
ZFYVE9
ZMYND11
ZNF41
ZNF510
ZNF8
ZNHIT6
Entrez ID
23216
4087
HPRD ID
18161
03221
Ensembl ID
ENSG00000065882
ENSG00000175387
Uniprot IDs
A0A8V8TNS9
B9A6J6
Q6PJJ8
Q86TI0
Q8NC59
B7Z5N5
Q15796
Q53XR6
PDB IDs
3QYE
1DEV
1KHX
1U7V
2LB3
5XOD
5ZOJ
6H3R
6M64
6YIA
6ZVQ
7CO1
Enriched GO Terms of Interacting Partners
?
Transporter Inhibitor Activity
Negative Regulation Of Calcium Ion Export Across Plasma Membrane
Regulation Of Calcium Ion Export Across Plasma Membrane
Adenylate Cyclase Activator Activity
Spindle Microtubule
Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction
Titin Binding
Regulation Of Cell Communication By Electrical Coupling
Negative Regulation Of High Voltage-gated Calcium Channel Activity
Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Detection Of Calcium Ion
Protein Phosphatase Activator Activity
Calyx Of Held
Catalytic Complex
Protein Kinase C Inhibitor Activity
Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion
Negative Regulation Of Transporter Activity
Calcium Channel Complex
Calcineurin-mediated Signaling
Presynaptic Cytosol
Myelin Sheath
Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling
Cytoskeleton
Regulation Of Synaptic Plasticity
Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum
Negative Regulation Of Calcium Ion Transmembrane Transport
Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Presynaptic Endocytosis
Positive Regulation Of Sequestering Of Calcium Ion
Substantia Nigra Development
Calcium Channel Regulator Activity
Negative Regulation Of Voltage-gated Calcium Channel Activity
Sperm Midpiece
Negative Regulation Of Calcium Ion Transport
G2/M Transition Of Mitotic Cell Cycle
Long-term Synaptic Potentiation
Sarcomere
Cellular Response To Nitrogen Starvation
Cell Cycle G2/M Phase Transition
Spindle Pole
Neural Nucleus Development
Adenylate Cyclase Binding
Regulation Of Muscle Contraction
Negative Regulation Of Cation Transmembrane Transport
Calcium Channel Inhibitor Activity
Protein Serine/threonine Kinase Activator Activity
Phosphatidylethanolamine Binding
Vesicle
Regulation Of Voltage-gated Calcium Channel Activity
Regulation Of DNA-templated Transcription
Regulation Of RNA Metabolic Process
Regulation Of RNA Biosynthetic Process
Nucleoplasm
SMAD Binding
Regulation Of Signal Transduction
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of RNA Metabolic Process
Regulation Of Cell Communication
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Signaling
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of Metabolic Process
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Macromolecule Metabolic Process
Regulation Of Gene Expression
Transcription Regulator Complex
Regulation Of Primary Metabolic Process
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Metabolic Process
Nucleus
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Cell Communication
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Regulation Of Cellular Response To Growth Factor Stimulus
Positive Regulation Of Signaling
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Intracellular Signal Transduction
Negative Regulation Of Signal Transduction
Regulation Of Developmental Process
Positive Regulation Of Signal Transduction
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Intracellular Signal Transduction
Chromatin
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Enzyme-linked Receptor Protein Signaling Pathway
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?