TBC1D1 and LHX8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TBC1D1	LHX8
Description		TBC1 domain family member 1	LIM homeobox 8
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Golgi Apparatus	Chromatin Nucleus
	Molecular Function	GTPase Activator Activity Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Cilium Assembly	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Forebrain Neuron Development Neuron Differentiation Response To Ethanol
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Amyotrophic lateral sclerosis in C9orf72 mutation negative individuals ( 22959728) Bipolar disorder ( 34099189) Crohn's disease ( 23266558 23850713) Diastolic blood pressure ( 27618452 27841878) Gut microbiota relative abundance (unclassified genus belonging to family Lachnospiraceae) ( 33208821) High-sensitivity cardiac troponin T levels ( 33321125) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Periodontal microbiota ( 22699663) Pulse pressure ( 27841878) Response to antidepressants (symptom remission) ( 29160301) Response to SSRI (symptom remission) ( 29160301) Systolic blood pressure ( 27841878 27618452) Verbal declarative memory ( 25648963) Weight ( 28552196) White blood cell count ( 32888494)
Interacting Genes		31 interacting genes: CALM1 CALM2 CALM3 CCDC185 CWF19L2 EFHC2 FAM161A FAM50B GABARAPL1 GMCL1 HOXC8 HSF2BP HSPB1 KRT75 L3MBTL3 LHX8 LNX1 LZTS1 MAP1LC3A MCRS1 PNKP RIN1 SMAD2 SYTL4 TCEA2 TNNC2 TSGA10IP TXLNA VPS52 YWHAG ZFP1	26 interacting genes: - ABI2 ATF2 ATF6B AXIN1 BANP CCHCR1 CRK CSNK2A1 EFS FIGLA FOSL2 FOXN1 GINS4 KLF3 KRT85 LDB2 NEDD9 NUTM1 PLCG2 PRPF31 SCYL3 SUV39H1 TBC1D1 TBC1D22B ZBTB24
Entrez ID		23216	431707
HPRD ID		18161	17275
Ensembl ID		ENSG00000065882	ENSG00000162624
Uniprot IDs		A0A8V8TNS9 B9A6J6 Q6PJJ8 Q86TI0 Q8NC59	Q68G74
PDB IDs		3QYE
Enriched GO Terms of Interacting Partners?		Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Spindle Microtubule Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Titin Binding Regulation Of Cell Communication By Electrical Coupling Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Detection Of Calcium Ion Protein Phosphatase Activator Activity Calyx Of Held Catalytic Complex Protein Kinase C Inhibitor Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Transporter Activity Calcium Channel Complex Calcineurin-mediated Signaling Presynaptic Cytosol Myelin Sheath Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Cytoskeleton Regulation Of Synaptic Plasticity Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Negative Regulation Of Calcium Ion Transmembrane Transport Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Presynaptic Endocytosis Positive Regulation Of Sequestering Of Calcium Ion Substantia Nigra Development Calcium Channel Regulator Activity Negative Regulation Of Voltage-gated Calcium Channel Activity Sperm Midpiece Negative Regulation Of Calcium Ion Transport G2/M Transition Of Mitotic Cell Cycle Long-term Synaptic Potentiation Sarcomere Cellular Response To Nitrogen Starvation Cell Cycle G2/M Phase Transition Spindle Pole Neural Nucleus Development Adenylate Cyclase Binding Regulation Of Muscle Contraction Negative Regulation Of Cation Transmembrane Transport Calcium Channel Inhibitor Activity Protein Serine/threonine Kinase Activator Activity Phosphatidylethanolamine Binding Vesicle Regulation Of Voltage-gated Calcium Channel Activity	NK T Cell Differentiation Nucleus Protein Tyrosine Kinase Binding Response To Endothelin Cellular Response To Endothelin RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Cell Development Signaling Adaptor Activity Response To Yeast Epigenetic Programming In The Zygotic Pronuclei DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Cellular Developmental Process Regulation Of Transcription By RNA Polymerase II
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