RALA and RAB34

Number of citations of the paper that reports this interaction (PubMedID 24056301)
0

Data Source:
BioGRID (two hybrid)

		RALA	RAB34
Description		RAS like proto-oncogene A	RAB34, member RAS oncogene family
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Plasma Membrane Focal Adhesion Cell Surface Membrane Endocytic Vesicle Cytoplasmic Vesicle Membrane Cleavage Furrow Extracellular Exosome Flemming Body Synaptic Membrane Schaffer Collateral - CA1 Synapse	Cytoplasm Golgi Apparatus Golgi Stack Centrosome Centriole Cytoskeleton Cilium Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Vesicle Golgi Cisterna Ruffle Membrane Cell Projection Phagocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Myosin Binding GDP Binding Ubiquitin Protein Ligase Binding Edg-2 Lysophosphatidic Acid Receptor Binding ATPase Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GTP-dependent Protein Binding Small GTPase Binding Metal Ion Binding
	Biological Process	Neural Tube Closure Exocytosis Chemotaxis Signal Transduction Ras Protein Signal Transduction Regulation Of Exocytosis Receptor Internalization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell Division Positive Regulation Of Filopodium Assembly Membrane Raft Localization Establishment Of Protein Localization To Mitochondrion Positive Regulation Of Mitochondrial Fission Regulation Of Postsynaptic Neurotransmitter Receptor Internalization	Protein Transport Antigen Processing And Presentation Cell Projection Organization Lysosome Localization Golgi To Plasma Membrane Protein Transport Macropinocytosis Positive Regulation Of Smoothened Signaling Pathway Cilium Assembly Cytosolic Ciliogenesis Protein Localization To Plasma Membrane Phagosome Maturation Phagosome-lysosome Fusion
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane p38MAPK events Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	RAB geranylgeranylation
Drugs		Guanosine-5'-Diphosphate
Diseases
GWAS			Urate levels in lean individuals ( 25811787)
Interacting Genes		31 interacting genes: ARF1 CALM1 CNKSR2 CTCF EXOC1 EXOC2 EXOC3 EXOC4 EXOC5 EXOC6B EXOC7 EXOC8 FLNA GLS2 HSPB1 LSM2 PIH1D2 PLCD1 PLD1 PPP2R1B RAB34 RAB8B RALBP1 RALGPS1 RASSF5 REPS1 RGL2 RGL4 SMAD4 SNCA YBX3	9 interacting genes: CA8 RABGAP1L RALA REP15 RILP SMAD1 SMAD2 SMAD4 TGFBR1
Entrez ID		5898	83871
HPRD ID		01549	06701
Ensembl ID		ENSG00000006451	ENSG00000109113
Uniprot IDs		P11233	B4DNC0 E7ES60 P0DI83 Q96PJ7 Q9BZG1
PDB IDs		1UAD 1ZC3 1ZC4 2A78 2A9K 2BOV 6P0I 6P0J 6P0K 6P0L 6P0M 6P0N 6P0O 7NQC 8FJH 8FJI
Enriched GO Terms of Interacting Partners?		Vesicle Tethering Involved In Exocytosis Exocyst Vesicle Tethering Vesicle Docking Involved In Exocytosis Membrane Fission Organelle Localization By Membrane Tethering Membrane Docking Vesicle Docking Mitotic Cytokinesis Exocytosis Cytoskeleton-dependent Cytokinesis Golgi To Plasma Membrane Transport Vesicle-mediated Transport To The Plasma Membrane Secretion By Cell Organelle Localization Post-Golgi Vesicle-mediated Transport Vesicle-mediated Transport Small GTPase Binding Secretion Membrane Organization Intracellular Protein Localization Flemming Body Establishment Of Protein Localization Localization Within Membrane Protein Transport Perinuclear Region Of Cytoplasm Golgi Vesicle Transport Regulation Of Norepinephrine Uptake Regulation Of Ral Protein Signal Transduction Transporter Regulator Activity Ras Protein Signal Transduction Cellular Localization Intracellular Signaling Cassette Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Cytoplasm Plasma Membrane Regulation Of Entry Of Bacterium Into Host Cell Negative Regulation Of Macrophage Differentiation Growth Cone Membrane Regulation Of Autophagy Platelet Aggregation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Growth Cone Small GTPase-mediated Signal Transduction Positive Regulation Of Hormone Secretion Homotypic Cell-cell Adhesion Cytosol Positive Regulation Of Secretion By Cell Positive Regulation Of Secretion	I-SMAD Binding SMAD Protein Complex Heteromeric SMAD Protein Complex Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Signal Transduction Homomeric SMAD Protein Complex Activin Receptor Signaling Pathway Activin Responsive Factor Complex Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Fate Commitment Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway SMAD Binding Embryonic Pattern Specification Positive Regulation Of Epithelial To Mesenchymal Transition Trophoblast Cell Migration Response To Transforming Growth Factor Beta Roof Of Mouth Development Ubiquitin Protein Ligase Binding Positive Regulation Of Extracellular Matrix Assembly Endothelial Cell Activation Response To Growth Factor Co-SMAD Binding Primary MiRNA Processing Secondary Palate Development Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Cardiac Conduction System Development Pattern Specification Process Ameboidal-type Cell Migration Regulation Of Extracellular Matrix Assembly Anterior/posterior Pattern Specification Response To Cholesterol R-SMAD Binding Positive Regulation Of Extracellular Matrix Organization Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of Filopodium Assembly Embryonic Cranial Skeleton Morphogenesis Embryonic Axis Specification Endoderm Development MiRNA Processing Tube Development Neuron Fate Commitment Ventricular Septum Morphogenesis Ureteric Bud Development Transcription Regulator Complex Enzyme-linked Receptor Protein Signaling Pathway Establishment Of Protein Localization In Utero Embryonic Development Positive Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Cell Differentiation
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