RALA and PIH1D2

Number of citations of the paper that reports this interaction (PMID 24056301)
1

Data Source:
BioGRID (two hybrid)

		RALA	PIH1D2
Gene Name		v-ral simian leukemia viral oncogene homolog A (ras related)	PIH1 domain containing 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Focal Adhesion Cell Surface Endocytic Vesicle Midbody Cytoplasmic Vesicle Membrane Cleavage Furrow Extracellular Vesicular Exosome
	Molecular Function	GTPase Activity Protein Binding GTP Binding Myosin Binding GDP Binding Ubiquitin Protein Ligase Binding Edg-2 Lysophosphatidic Acid Receptor Binding ATPase Binding	Ral GTPase Binding
	Biological Process	Cytokinesis Exocytosis Chemotaxis Signal Transduction Ras Protein Signal Transduction Viral Process Regulation Of Exocytosis Actin Cytoskeleton Reorganization Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Filopodium Assembly Membrane Raft Localization Membrane Organization
Pathways		Signalling to ERKs Signalling by NGF Signalling to RAS p38MAPK events Translocation of GLUT4 to the plasma membrane NGF signalling via TRKA from the plasma membrane
Drugs
Diseases
GWAS
Protein-Protein Interactions		32 interactors: ARF1 CALM1 CNKSR2 EXOC1 EXOC2 EXOC3 EXOC4 EXOC5 EXOC6B EXOC7 EXOC8 FLNA HRAS LRPAP1 LSM2 PIH1D2 PLCD1 PLD1 PPP2R1B RAB34 RAB8B RALBP1 RALGPS1 RAP1A RAP2A RAP2B RASSF5 REPS1 RGL2 RGL4 SMAD4 YBX3	11 interactors: DPH3 EIF4A2 GFAP IGF2BP3 ITGB3BP KRTAP12-4 MDFI MRFAP1L1 MVP RALA REL
Entrez ID		5898	120379
HPRD ID		01549	14021
Ensembl ID		ENSG00000006451	ENSG00000150773
Uniprot IDs		P11233	E9PD82 Q8WWB5
PDB IDs		1UAD 1ZC3 1ZC4 2A78 2A9K 2BOV
Enriched GO Terms of Interacting Partners?		Exocytosis Vesicle-mediated Transport Small GTPase Mediated Signal Transduction Membrane Organization Secretion By Cell Intracellular Signal Transduction Secretion Ras Protein Signal Transduction Establishment Of Protein Localization Protein Localization Vesicle Docking Protein Transport Membrane Docking Rap Protein Signal Transduction Establishment Of Localization In Cell Cellular Localization Vesicle Docking Involved In Exocytosis Positive Regulation Of Protein Autophosphorylation Regulation Of Signaling Post-Golgi Vesicle-mediated Transport Transport Regulation Of Protein Autophosphorylation Organelle Organization Regulation Of Signal Transduction Golgi Vesicle Transport Exocyst Localization Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Platelet Activation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Signaling Cellular Protein Complex Localization Blood Coagulation Cell Communication Positive Regulation Of Ras GTPase Activity Hemostasis Positive Regulation Of Hydrolase Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of GTPase Activity Protein Complex Localization Cellular Response To Stimulus Regulation Of Cell Projection Organization Regulation Of GTPase Activity Regulation Of Ras GTPase Activity Positive Regulation Of Metabolic Process Positive Regulation Of Phosphorylation Regulation Of Body Fluid Levels Wound Healing Golgi To Plasma Membrane Transport	Negative Regulation Of RNA-directed RNA Polymerase Activity Positive Regulation Of Schwann Cell Proliferation Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cytokine Biosynthetic Process MRNA Transport Negative Regulation Of Biosynthetic Process RNA Transport RNA Localization Membrane Raft Localization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Protein Transport Regulation Of Cellular Process Bergmann Glial Cell Differentiation Cellular Response To Stimulus Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Binding Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Interleukin-12 Biosynthetic Process Negative Regulation Of Protein Autophosphorylation Regulation Of Translation Signal Transduction Positive Regulation Of Glial Cell Proliferation Regulation Of Neurotransmitter Uptake Peptidyl-diphthamide Biosynthetic Process From Peptidyl-histidine Negative Regulation Of Transferase Activity Regulation Of Cellular Localization Intermediate Filament Organization Regulation Of Interleukin-12 Biosynthetic Process Negative Regulation Of Protein Tyrosine Kinase Activity Trophoblast Giant Cell Differentiation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Signaling Astrocyte Development Cell Communication Cytoplasmic Sequestering Of Transcription Factor Dorsal/ventral Axis Specification
Tagcloud ?		adoptive antitumor capability chimeric combining effectors engineered fused genetically gtp immunotherapeutic killer meaningful mhc moieties ncr1 ncrs nk nkp46 partly proto ralb recognition recognize regressions remarkable retrovirally termed
Tagcloud (Difference) ?		adoptive antitumor capability chimeric combining effectors engineered fused genetically gtp immunotherapeutic killer meaningful mhc moieties ncr1 ncrs nk nkp46 partly proto ralb recognition recognize regressions remarkable retrovirally termed
Tagcloud (Intersection) ?