RALA and RGL2

Number of citations of the paper that reports this interaction (PubMedID 8939933)
0

Data Source:
BioGRID (two hybrid)

		RALA	RGL2
Description		RAS like proto-oncogene A	ral guanine nucleotide dissociation stimulator like 2
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GO Annotations	Cellular Component	Mitochondrion Plasma Membrane Focal Adhesion Cell Surface Membrane Endocytic Vesicle Cytoplasmic Vesicle Membrane Cleavage Furrow Extracellular Exosome Flemming Body Synaptic Membrane Schaffer Collateral - CA1 Synapse	Cytosol
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Myosin Binding GDP Binding Ubiquitin Protein Ligase Binding Edg-2 Lysophosphatidic Acid Receptor Binding ATPase Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Neural Tube Closure Exocytosis Chemotaxis Signal Transduction Ras Protein Signal Transduction Regulation Of Exocytosis Receptor Internalization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell Division Positive Regulation Of Filopodium Assembly Membrane Raft Localization Establishment Of Protein Localization To Mitochondrion Positive Regulation Of Mitochondrial Fission Regulation Of Postsynaptic Neurotransmitter Receptor Internalization	Signal Transduction Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Regulation Of Ral Protein Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane p38MAPK events Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	RAF/MAP kinase cascade
Drugs		Guanosine-5'-Diphosphate
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026)
Interacting Genes		31 interacting genes: ARF1 CALM1 CNKSR2 CTCF EXOC1 EXOC2 EXOC3 EXOC4 EXOC5 EXOC6B EXOC7 EXOC8 FLNA GLS2 HSPB1 LSM2 PIH1D2 PLCD1 PLD1 PPP2R1B RAB34 RAB8B RALBP1 RALGPS1 RASSF5 REPS1 RGL2 RGL4 SMAD4 SNCA YBX3	19 interacting genes: ADAMTSL4 CCDC90B CRMP1 CYSRT1 EEF1G GORASP2 HRAS KAT5 KAT7 KPNA2 KPRP KRAS KRTAP10-8 NOTCH2NLA NRAS RAC1 RALA RAP1B UNC119
Entrez ID		5898	5863
HPRD ID		01549	03810
Ensembl ID		ENSG00000006451	ENSG00000237441
Uniprot IDs		P11233	A0A024RCS9 O15211
PDB IDs		1UAD 1ZC3 1ZC4 2A78 2A9K 2BOV 6P0I 6P0J 6P0K 6P0L 6P0M 6P0N 6P0O 7NQC 8FJH 8FJI	8AU4 8B69
Enriched GO Terms of Interacting Partners?		Vesicle Tethering Involved In Exocytosis Exocyst Vesicle Tethering Vesicle Docking Involved In Exocytosis Membrane Fission Organelle Localization By Membrane Tethering Membrane Docking Vesicle Docking Mitotic Cytokinesis Exocytosis Cytoskeleton-dependent Cytokinesis Golgi To Plasma Membrane Transport Vesicle-mediated Transport To The Plasma Membrane Secretion By Cell Organelle Localization Post-Golgi Vesicle-mediated Transport Vesicle-mediated Transport Small GTPase Binding Secretion Membrane Organization Intracellular Protein Localization Flemming Body Establishment Of Protein Localization Localization Within Membrane Protein Transport Perinuclear Region Of Cytoplasm Golgi Vesicle Transport Regulation Of Norepinephrine Uptake Regulation Of Ral Protein Signal Transduction Transporter Regulator Activity Ras Protein Signal Transduction Cellular Localization Intracellular Signaling Cassette Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Cytoplasm Plasma Membrane Regulation Of Entry Of Bacterium Into Host Cell Negative Regulation Of Macrophage Differentiation Growth Cone Membrane Regulation Of Autophagy Platelet Aggregation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Growth Cone Small GTPase-mediated Signal Transduction Positive Regulation Of Hormone Secretion Homotypic Cell-cell Adhesion Cytosol Positive Regulation Of Secretion By Cell Positive Regulation Of Secretion	G Protein Activity GDP Binding Small GTPase-mediated Signal Transduction GTPase Activity GTP Binding Ras Protein Signal Transduction Intracellular Signaling Cassette Regulation Of Neuronal Synaptic Plasticity Histone H4K16 Acetyltransferase Activity Intracellular Signal Transduction Histone H4 Acetyltransferase Activity Developmental Process Peptidyl-lysine Acetylation Positive Regulation Of Ruffle Assembly Cell Development Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Rac Protein Signal Transduction Regulation Of Receptor-mediated Endocytosis Histone Acetyltransferase Complex Regulation Of Long-term Neuronal Synaptic Plasticity Signal Transduction Golgi Membrane Regulation Of Ruffle Assembly Protein-containing Complex Binding Negative Regulation Of Receptor-mediated Endocytosis Histone Acetyltransferase Activity Protein Acetylation Protein-membrane Adaptor Activity Endoplasmic Reticulum Membrane Establishment Of Skin Barrier Homeostasis Of Number Of Cells Within A Tissue Semaphorin-plexin Signaling Pathway Regulation Of Postsynapse Assembly Histone H2AK5 Acetyltransferase Activity Histone H3K23 Acetyltransferase Activity Histone H3K4 Acetyltransferase Activity Pigment Cell Development Skin Epidermis Development Hydrolase Activity Response To Radiation Endocytosis Regulation Of Cell Projection Assembly Regulation Of Synaptic Plasticity Positive Regulation Of Cellular Component Biogenesis Cellular Developmental Process GTPase Complex Cellular Senescence Modulation Of Chemical Synaptic Transmission MAPK Cascade Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin
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