RALA and RAB8B

Number of citations of the paper that reports this interaction (PMID 10889189)
7

Data Source:
HPRD (in vitro, in vivo)

		RALA	RAB8B
Gene Name		v-ral simian leukemia viral oncogene homolog A (ras related)	RAB8B, member RAS oncogene family
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Focal Adhesion Cell Surface Endocytic Vesicle Midbody Cytoplasmic Vesicle Membrane Cleavage Furrow Extracellular Vesicular Exosome	Mitochondrion Endosome Peroxisomal Membrane Plasma Membrane Synaptic Vesicle Trans-Golgi Network Transport Vesicle Secretory Granule Membrane Phagocytic Vesicle Membrane Phagocytic Vesicle Perinuclear Region Of Cytoplasm Cell Tip Extracellular Vesicular Exosome
	Molecular Function	GTPase Activity Protein Binding GTP Binding Myosin Binding GDP Binding Ubiquitin Protein Ligase Binding Edg-2 Lysophosphatidic Acid Receptor Binding ATPase Binding	GTPase Activity Receptor Binding Protein Binding GTP Binding GDP Binding TPR Domain Binding
	Biological Process	Cytokinesis Exocytosis Chemotaxis Signal Transduction Ras Protein Signal Transduction Viral Process Regulation Of Exocytosis Actin Cytoskeleton Reorganization Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Filopodium Assembly Membrane Raft Localization Membrane Organization	Vesicle Docking Involved In Exocytosis Protein Secretion Synaptic Vesicle Exocytosis Regulation Of Exocytosis Antigen Processing And Presentation Positive Regulation Of Cell Projection Organization Rab Protein Signal Transduction Cellular Response To Insulin Stimulus Adherens Junction Organization Cilium Assembly Protein Import Into Peroxisome Membrane Golgi Vesicle Fusion To Target Membrane Positive Regulation Of Corticotropin Secretion Protein Localization To Plasma Membrane
Pathways		Signalling to ERKs Signalling by NGF Signalling to RAS p38MAPK events Translocation of GLUT4 to the plasma membrane NGF signalling via TRKA from the plasma membrane
Drugs
Diseases
GWAS
Protein-Protein Interactions		32 interactors: ARF1 CALM1 CNKSR2 EXOC1 EXOC2 EXOC3 EXOC4 EXOC5 EXOC6B EXOC7 EXOC8 FLNA HRAS LRPAP1 LSM2 PIH1D2 PLCD1 PLD1 PPP2R1B RAB34 RAB8B RALBP1 RALGPS1 RAP1A RAP2A RAP2B RASSF5 REPS1 RGL2 RGL4 SMAD4 YBX3	7 interactors: APP CDH1 RAB3IP RALA TUBA4A TUBB VIM
Entrez ID		5898	51762
HPRD ID		01549	11476
Ensembl ID		ENSG00000006451	ENSG00000166128
Uniprot IDs		P11233	F5GY21 Q92930
PDB IDs		1UAD 1ZC3 1ZC4 2A78 2A9K 2BOV
Enriched GO Terms of Interacting Partners?		Exocytosis Vesicle-mediated Transport Small GTPase Mediated Signal Transduction Membrane Organization Secretion By Cell Intracellular Signal Transduction Secretion Ras Protein Signal Transduction Establishment Of Protein Localization Protein Localization Vesicle Docking Protein Transport Membrane Docking Rap Protein Signal Transduction Establishment Of Localization In Cell Cellular Localization Vesicle Docking Involved In Exocytosis Positive Regulation Of Protein Autophosphorylation Regulation Of Signaling Post-Golgi Vesicle-mediated Transport Transport Regulation Of Protein Autophosphorylation Organelle Organization Regulation Of Signal Transduction Golgi Vesicle Transport Exocyst Localization Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Platelet Activation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Signaling Cellular Protein Complex Localization Blood Coagulation Cell Communication Positive Regulation Of Ras GTPase Activity Hemostasis Positive Regulation Of Hydrolase Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of GTPase Activity Protein Complex Localization Cellular Response To Stimulus Regulation Of Cell Projection Organization Regulation Of GTPase Activity Regulation Of Ras GTPase Activity Positive Regulation Of Metabolic Process Positive Regulation Of Phosphorylation Regulation Of Body Fluid Levels Wound Healing Golgi To Plasma Membrane Transport	Cellular Localization Organelle Organization Lens Fiber Cell Differentiation Cellular Component Assembly Establishment Of Localization In Cell Exocytosis Cell Cycle Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cytoskeleton Organization Platelet Degranulation Cell Division Execution Phase Of Apoptosis Synapse Assembly Cell Cycle Secretion By Cell Lens Development In Camera-type Eye Protein Polymerization Vesicle-mediated Transport Regulation Of Body Fluid Levels G2/M Transition Of Mitotic Cell Cycle Synaptic Growth At Neuromuscular Junction Secretion Cytoskeleton-dependent Intracellular Transport Mitotic Cell Cycle Process Regulation Of Neurogenesis Collateral Sprouting In Absence Of Injury Mitotic Cell Cycle Microtubule-based Process Synapse Organization Membrane Raft Localization Negative Regulation Of Neuron Differentiation Platelet Activation Collateral Sprouting Axon Midline Choice Point Recognition Cellular Response To Indole-3-methanol Regulation Of Cell Development Membrane Organization Epithelial Cell Development Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Activation Of Anaphase-promoting Complex Activity Axon Choice Point Recognition Establishment Of Protein Localization To Membrane Apoptotic Process Central Nervous System Development Bergmann Glial Cell Differentiation Salivary Gland Cavitation Programmed Cell Death Mitotic Cell Cycle Phase Transition Protein Complex Assembly Cell Cycle Phase Transition
Tagcloud ?		adoptive antitumor capability chimeric combining effectors engineered fused genetically gtp immunotherapeutic killer meaningful mhc moieties ncr1 ncrs nk nkp46 partly proto ralb recognition recognize regressions remarkable retrovirally termed	1a 1b adaptor addiction ap2 ca1 cation channels cyclic electrophysiology gated hcn hcn1 hcn2 hippocampal hyperpolarization imbalance learning ltp maze morphine mu2 neurological pka potentiation sc tpr trip8b vital
Tagcloud (Difference) ?		adoptive antitumor capability chimeric combining effectors engineered fused genetically gtp immunotherapeutic killer meaningful mhc moieties ncr1 ncrs nk nkp46 partly proto ralb recognition recognize regressions remarkable retrovirally termed	1a 1b adaptor addiction ap2 ca1 cation channels cyclic electrophysiology gated hcn hcn1 hcn2 hippocampal hyperpolarization imbalance learning ltp maze morphine mu2 neurological pka potentiation sc tpr trip8b vital
Tagcloud (Intersection) ?