HECW1 and CACNA1A

Number of citations of the paper that reports this interaction (PubMedID 21078624)
125

Data Source:
BioGRID (two hybrid)

		HECW1	CACNA1A
Description		HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	calcium voltage-gated channel subunit alpha1 A
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GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Cytoplasm Plasma Membrane Voltage-gated Calcium Channel Complex Membrane Monoatomic Ion Channel Complex Cell Projection Neuronal Cell Body Synapse
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin Protein Ligase Activity	Amyloid-beta Binding Monoatomic Ion Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity Syntaxin Binding Metal Ion Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Regulation Of Dendrite Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway	Monoatomic Ion Transport Calcium Ion Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport Modulation Of Chemical Synaptic Transmission Transmembrane Transport Calcium Ion Transmembrane Transport Calcium Ion Import Across Plasma Membrane Response To Amyloid-beta Cellular Response To Amyloid-beta
Pathways		Degradation of DVL	Presynaptic depolarization and calcium channel opening Regulation of insulin secretion
Drugs			Ergocalciferol Enflurane Phenytoin Spironolactone Nicardipine Magnesium sulfate Verapamil Verapamil Levomenthol Loperamide Nitrendipine Bepridil Ziconotide Dotarizine Drotaverine Trimebutine Benidipine Cilnidipine Efonidipine Lacidipine Manidipine Butamben Bioallethrin Bioallethrin Bioallethrin
Diseases			Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3) Episodic ataxias Familial or sporadic hemiplegic migraine
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Bone mineral density (Ward's triangle area) ( 27397699) Caudal anterior-cingulate cortex volume ( 31530798) Cerebrospinal fluid AB1-42 levels ( 26252872) Delirium ( 29631748) Diverticular disease ( 28585551) Irritable bowel syndrome ( 29673008) Lung cancer in ever smokers ( 28604730) Mercury levels ( 26025379) Obesity-related traits ( 23251661) Serum galactose-deficient IgA1 levels ( 28187132) Type 2 diabetes ( 25102180)	Exfoliation syndrome ( 25706626) Proteinuria and chronic kidney disease ( 26420894)
Interacting Genes		19 interacting genes: CACNA1A DVL1 GFI1B PRRG4 SCNN1A SCNN1B SHANK3 SSR4 TNK2 TP53 TSC1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2J2 UBE2L3 USP7 VAX1	92 interacting genes: ABCA2 ABI1 ACTN1 ADGRL1 AGRN ALDOA AMIGO2 AP2M1 ARHGAP22 BTG3 C1QTNF1 CABP1 CACNB1 CACNB4 CALM2 CALM3 CKAP5 CRIM1 CRMP1 CSNK2B CYSRT1 DNAJB5 EFEMP1 EFEMP2 EHMT2 EIF3A FBLN1 GET3 GNB1 GOLGA6L5P GRN HECW1 HHATL HIVEP1 HSPG2 IP6K1 JAG2 KALRN KHDRBS3 KIAA1191 LAMB1 LLGL1 LRP1 LTBP1 LTBP3 LTBP4 MANBAL MATK MATN2 MEGF6 MEGF8 MIA3 MOAP1 NDUFB8 NELFCD NELL1 NELL2 NOTCH1 NOXA1 OLIG1 PCSK5 PCSK6 PMM1 PPIG PPM1A PPP1R12C PTGDS PUF60 RBM12B RIMBP2 RPL31 RPS17 SCP2 SPRY1 SRRM4 SRSF1 SUMF2 SYT1 TAF15 TELO2 TSC22D1 TSPAN7 TSPOAP1 TUBB2B UQCRC2 VARS1 VPS52 VWF WBP1 YLPM1 ZCCHC17 ZNF233
Entrez ID		23072	773
HPRD ID		11385	03004
Ensembl ID		ENSG00000002746	ENSG00000141837
Uniprot IDs		Q76N89	A0A087WW63 B5TYJ1 O00555 Q9NS89
PDB IDs		3L4H	3BXK 8X90 8X91 8X93
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity WW Domain Binding Protein Ubiquitination Sensory Perception Of Salty Taste Protein Modification By Small Protein Conjugation Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Protein Polyubiquitination Cellular Response To Aldosterone Sodium Channel Complex Ubiquitin Protein Ligase Binding Post-translational Protein Modification Proteolysis Modification-dependent Protein Catabolic Process Regulation Of Protein Targeting To Mitochondrion Sensory Perception Of Sour Taste Cellular Response To Vasopressin TORC1 Signaling Cellular Response To Corticosteroid Stimulus Negative Regulation Of TORC1 Signaling Proteolysis Involved In Protein Catabolic Process Cellular Response To Mineralocorticoid Stimulus Ligand-gated Sodium Channel Activity Negative Regulation Of ATP-dependent Activity Negative Regulation Of Neuroblast Proliferation Cellular Response To Steroid Hormone Stimulus TOR Signaling Protein Stabilization Negative Regulation Of TOR Signaling Inorganic Cation Import Across Plasma Membrane Response To Nutrient Levels Ubiquitin-protein Transferase Activity Response To Aldosterone Cellular Response To Nutrient Levels Regulation Of TORC1 Signaling Dendritic Spine Morphogenesis Cellular Response To Acidic PH Negative Regulation Of Autophagy Protein K48-linked Ubiquitination Intracellular Sodium Ion Homeostasis Ubiquitin-dependent Protein Catabolic Process Sodium Ion Import Across Plasma Membrane Response To Acidic PH Protein K6-linked Ubiquitination Cellular Response To PH Negative Regulation Of Neural Precursor Cell Proliferation Multicellular Organismal-level Water Homeostasis Import Across Plasma Membrane Positive Regulation Of Excitatory Postsynaptic Potential Dendritic Spine Organization	Calcium Ion Binding Extracellular Matrix Structural Constituent Extracellular Matrix Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Embryo Implantation Calcium Channel Regulator Activity Basement Membrane Microfibril Voltage-gated Calcium Channel Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Levels Detection Of Calcium Ion Auditory Receptor Cell Fate Commitment Protein Binding Calyx Of Held Integrin Binding Astrocyte Activation Involved In Immune Response Transforming Growth Factor Beta Binding Extracellular Region Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Elastic Fiber Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Inhibitor Activity Low-density Lipoprotein Particle Receptor Binding Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Presynaptic Cytosol Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Population Proliferation Regulation Of Extracellular Matrix Organization Regulation Of Alternative MRNA Splicing, Via Spliceosome
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