Wiki-Pi
Answer Survey
Home
About
Help
Advanced Search
HECW1 and CACNA1A
Number of citations of the paper that reports this interaction (PMID
21078624
)
14
Data Source:
BioGRID
(two hybrid)
HECW1
CACNA1A
Gene Name
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
Image
Gene Ontology Annotations
Cellular Component
Cytosol
Nucleus
Cytoplasm
Plasma Membrane
Voltage-gated Calcium Channel Complex
Integral Component Of Membrane
Dendrite
Cell Projection
Neuronal Cell Body
Molecular Function
Ubiquitin-protein Transferase Activity
Ligase Activity
Voltage-gated Calcium Channel Activity
Protein Binding
High Voltage-gated Calcium Channel Activity
Syntaxin Binding
Metal Ion Binding
Biological Process
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Canonical Wnt Signaling Pathway
Sulfur Amino Acid Metabolic Process
Glucose Metabolic Process
Energy Reserve Metabolic Process
Positive Regulation Of Cytosolic Calcium Ion Concentration
Gamma-aminobutyric Acid Signaling Pathway
Synaptic Transmission
Neuromuscular Synaptic Transmission
Synapse Assembly
Adult Walking Behavior
Cell Death
Gamma-aminobutyric Acid Secretion
Regulation Of Acetylcholine Secretion, Neurotransmission
Cell Growth
Calcium Ion-dependent Exocytosis
Regulation Of Calcium Ion-dependent Exocytosis
Transmission Of Nerve Impulse
Spinal Cord Motor Neuron Differentiation
Cerebellum Maturation
Cerebellar Molecular Layer Development
Cerebellar Purkinje Cell Differentiation
Vestibular Nucleus Development
Cellular Chloride Ion Homeostasis
Negative Regulation Of Hormone Biosynthetic Process
Regulation Of Ion Transmembrane Transport
Synaptic Transmission, Glutamatergic
Neurotransmitter Metabolic Process
Hormone Metabolic Process
Receptor Clustering
Negative Regulation Of Neuron Apoptotic Process
Small Molecule Metabolic Process
Behavioral Response To Pain
Calcium Ion-dependent Exocytosis Of Neurotransmitter
Dendrite Morphogenesis
Regulation Of Axonogenesis
Regulation Of Insulin Secretion
Musculoskeletal Movement, Spinal Reflex Action
Neuromuscular Process Controlling Balance
Membrane Depolarization
Rhythmic Synaptic Transmission
Calcium Ion Import
Calcium Ion Transmembrane Transport
Membrane Depolarization During Action Potential
Pathways
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
TCF dependent signaling in response to WNT
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
degradation of DVL
Signaling by Wnt
Signaling by WNT in cancer
Integration of energy metabolism
Regulation of insulin secretion
Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels
Transmission across Chemical Synapses
Drugs
Pregabalin
Verapamil
Loperamide
Bepridil
Diseases
GWAS
Alzheimer's disease (cognitive decline) (
23535033
)
Obesity-related traits (
23251661
)
Protein-Protein Interactions
10 interactors:
CACNA1A
DVL1
GFI1B
SCNN1A
SCNN1B
SSR4
TNK2
TP53
UBC
USP7
92 interactors:
ABCA2
ABI1
ACTN1
AGRN
ALDOA
AMIGO2
AP2M1
ARHGAP22
ASNA1
BTG3
BZRAP1
C1QTNF1
CABP1
CACNB1
CACNB4
CALM2
CALM3
CKAP5
CRIM1
CRMP1
CSNK2B
CYSRT1
DNAJB5
EFEMP1
EFEMP2
EHMT2
EIF3A
FBLN1
GNB1
GOLGA6L5P
GRN
HECW1
HHATL
HIVEP1
HSPG2
IP6K1
JAG2
KALRN
KHDRBS3
KIAA1191
LAMB1
LLGL1
LPHN1
LRP1
LTBP1
LTBP3
LTBP4
MANBAL
MATK
MATN2
MEGF6
MEGF8
MIA3
MOAP1
NDUFB8
NELFCD
NELL1
NELL2
NOTCH1
NOXA1
OLIG1
PCSK5
PCSK6
PMM1
PPIG
PPM1A
PPP1R12C
PTGDS
PUF60
RBM12B
RIMBP2
RPL31
RPS17
SCP2
SPRY1
SRRM4
SRSF1
SUMF2
SYT1
TAF15
TELO2
TSC22D1
TSPAN7
TUBB2B
UQCRC2
VARS
VPS52
VWF
WBP1
YLPM1
ZCCHC17
ZNF233
Entrez ID
23072
773
HPRD ID
11385
03004
Ensembl ID
ENSG00000141837
Uniprot IDs
B4DH42
Q76N89
B5TYJ1
O00555
Q9NS89
PDB IDs
3L4H
3BXK
Enriched GO Terms of Interacting Partners
?
Membrane Organization
Sodium Ion Homeostasis
Regulation Of Cellular Protein Metabolic Process
Regulation Of Protein Metabolic Process
Transport
Excretion
Multicellular Organismal Water Homeostasis
Negative Regulation Of Catalytic Activity
Receptor Clustering
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint
Signal Transduction Involved In DNA Damage Checkpoint
Signal Transduction Involved In Cell Cycle Checkpoint
Water Homeostasis
Sensory Perception Of Taste
Transcription From RNA Polymerase II Promoter
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Mitotic G1 DNA Damage Checkpoint
Mitotic G1/S Transition Checkpoint
G1 DNA Damage Checkpoint
Protein Localization To Membrane
Positive Regulation Of Cell Cycle Arrest
Cerebellar Molecular Layer Development
DNA Damage Response, Signal Transduction By P53 Class Mediator
Regulation Of Protein Catabolic Process
Dendrite Morphogenesis
Regulation Of Cellular Component Organization
Signal Transduction In Response To DNA Damage
Regulation Of Protein Phosphorylation
Nucleotide-excision Repair
Mitotic DNA Damage Checkpoint
Regulation Of Cell Cycle Arrest
Establishment Of Localization In Cell
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Cellular Response To Hypoxia
Mitotic DNA Integrity Checkpoint
Cellular Response To Decreased Oxygen Levels
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Metal Ion Homeostasis
Negative Regulation Of Macromitophagy
Vestibular Nucleus Development
Oligodendrocyte Apoptotic Process
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Negative Regulation Of Cellular Metabolic Process
Neurological System Process
Neurotransmitter Secretion
Growth
Cellular Response To Oxygen Levels
Secretion By Cell
Secretion
Extracellular Matrix Organization
Extracellular Structure Organization
Regulation Of Voltage-gated Calcium Channel Activity
Detection Of Visible Light
Enzyme Linked Receptor Protein Signaling Pathway
Detection Of Light Stimulus
Multicellular Organismal Development
Phototransduction, Visible Light
Anatomical Structure Development
Cellular Localization
Axon Development
Developmental Process
Establishment Of Localization In Cell
Phototransduction
Regulation Of Cellular Process
System Development
Axonogenesis
Regulation Of Calcium Ion Transmembrane Transport
Regulation Of Calcium Ion Transmembrane Transporter Activity
Detection Of Abiotic Stimulus
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Platelet Degranulation
Cell Morphogenesis Involved In Neuron Differentiation
Anatomical Structure Morphogenesis
Regulation Of Cation Channel Activity
Axon Guidance
Nervous System Development
Detection Of Calcium Ion
Regulation Of Intracellular Cholesterol Transport
Regulation Of Cell Communication By Electrical Coupling
Neuron Projection Morphogenesis
Exocytosis
Neuron Projection Development
Cellular Response To Growth Factor Stimulus
Neuron Differentiation
Inositol Phosphate Metabolic Process
Cell Projection Morphogenesis
Negative Regulation Of Calcium Ion Transmembrane Transporter Activity
Cell Morphogenesis Involved In Differentiation
Cell Part Morphogenesis
Response To Growth Factor
Cell Surface Receptor Signaling Pathway
Negative Regulation Of Cation Channel Activity
Platelet Activation
Cell-cell Signaling
Nerve Growth Factor Processing
Pathogenesis
Neurotrophin TRK Receptor Signaling Pathway
Tagcloud
?
acetazolamide
ataxia
attacks
autosomal
causative
causing
coincidence
confutes
defect
dysarthria
dystonia
ea
ea2
encodes
episodes
episodic
gait
gated
heterogeneous
inherited
migraine
mim
nonsense
oculomotor
paroxysmal
q
varied
voltage
Tagcloud (Difference)
?
acetazolamide
ataxia
attacks
autosomal
causative
causing
coincidence
confutes
defect
dysarthria
dystonia
ea
ea2
encodes
episodes
episodic
gait
gated
heterogeneous
inherited
migraine
mim
nonsense
oculomotor
paroxysmal
q
varied
voltage
Tagcloud (Intersection)
?