CACNA1A and PPM1A

Number of citations of the paper that reports this interaction (PubMedID 15728831)
53

Data Source:
HPRD (in vitro, in vivo)

		CACNA1A	PPM1A
Description		calcium voltage-gated channel subunit alpha1 A	protein phosphatase, Mg2+/Mn2+ dependent 1A
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GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Voltage-gated Calcium Channel Complex Membrane Monoatomic Ion Channel Complex Cell Projection Neuronal Cell Body Synapse	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Amyloid-beta Binding Monoatomic Ion Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity Syntaxin Binding Metal Ion Binding	Magnesium Ion Binding Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Manganese Ion Binding Calmodulin-dependent Protein Phosphatase Activity Cation Binding Metal Ion Binding R-SMAD Binding
	Biological Process	Monoatomic Ion Transport Calcium Ion Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport Modulation Of Chemical Synaptic Transmission Transmembrane Transport Calcium Ion Transmembrane Transport Calcium Ion Import Across Plasma Membrane Response To Amyloid-beta Cellular Response To Amyloid-beta	Negative Regulation Of Transcription By RNA Polymerase II Protein Dephosphorylation N-terminal Protein Myristoylation Protein Export From Nucleus Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of DNA-templated Transcription Positive Regulation Of Protein Export From Nucleus Regulation Of Cell Cycle Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways		Presynaptic depolarization and calcium channel opening Regulation of insulin secretion	Downregulation of SMAD2/3:SMAD4 transcriptional activity Energy dependent regulation of mTOR by LKB1-AMPK
Drugs		Ergocalciferol Enflurane Phenytoin Spironolactone Nicardipine Magnesium sulfate Verapamil Verapamil Levomenthol Loperamide Nitrendipine Bepridil Ziconotide Dotarizine Drotaverine Trimebutine Benidipine Cilnidipine Efonidipine Lacidipine Manidipine Butamben Bioallethrin Bioallethrin Bioallethrin
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3) Episodic ataxias Familial or sporadic hemiplegic migraine
GWAS		Exfoliation syndrome ( 25706626) Proteinuria and chronic kidney disease ( 26420894)	Allergic rhinitis ( 22036096) Blond vs. brown/black hair color ( 30531825) Chronotype ( 30696823) Diastolic blood pressure ( 30224653) Hair color ( 29662168) Hip circumference adjusted for BMI ( 25673412) Menarche (age at onset) ( 27182965) Refractive error ( 32231278) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		92 interacting genes: ABCA2 ABI1 ACTN1 ADGRL1 AGRN ALDOA AMIGO2 AP2M1 ARHGAP22 BTG3 C1QTNF1 CABP1 CACNB1 CACNB4 CALM2 CALM3 CKAP5 CRIM1 CRMP1 CSNK2B CYSRT1 DNAJB5 EFEMP1 EFEMP2 EHMT2 EIF3A FBLN1 GET3 GNB1 GOLGA6L5P GRN HECW1 HHATL HIVEP1 HSPG2 IP6K1 JAG2 KALRN KHDRBS3 KIAA1191 LAMB1 LLGL1 LRP1 LTBP1 LTBP3 LTBP4 MANBAL MATK MATN2 MEGF6 MEGF8 MIA3 MOAP1 NDUFB8 NELFCD NELL1 NELL2 NOTCH1 NOXA1 OLIG1 PCSK5 PCSK6 PMM1 PPIG PPM1A PPP1R12C PTGDS PUF60 RBM12B RIMBP2 RPL31 RPS17 SCP2 SPRY1 SRRM4 SRSF1 SUMF2 SYT1 TAF15 TELO2 TSC22D1 TSPAN7 TSPOAP1 TUBB2B UQCRC2 VARS1 VPS52 VWF WBP1 YLPM1 ZCCHC17 ZNF233	38 interacting genes: AATK AKT1 ALK CACNA1A CACNA1B CACNA1C CDC42BPA CDC42BPB CTNNB1 DVL1 DVL2 DVL3 EEF2 EGFR ERBB2 ERBB3 ERBB4 FGFR2 GRM3 HSPB1 IGF1R KDR LMTK2 MID1 MSN NR4A1 PAK1 PAK2 PIK3R1 PLK3 PRKAA1 PRKCA PRKCD PTK7 ROR2 RPLP0 SMAD2 SMAD3
Entrez ID		773	5494
HPRD ID		03004	16199
Ensembl ID		ENSG00000141837	ENSG00000100614
Uniprot IDs		A0A087WW63 B5TYJ1 O00555 Q9NS89	B2R8E4 P35813
PDB IDs		3BXK 8X90 8X91 8X93	1A6Q 3FXJ 3FXK 3FXL 3FXM 3FXO 4RA2 4RAF 4RAG 6B67
Enriched GO Terms of Interacting Partners?		Calcium Ion Binding Extracellular Matrix Structural Constituent Extracellular Matrix Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Embryo Implantation Calcium Channel Regulator Activity Basement Membrane Microfibril Voltage-gated Calcium Channel Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Levels Detection Of Calcium Ion Auditory Receptor Cell Fate Commitment Protein Binding Calyx Of Held Integrin Binding Astrocyte Activation Involved In Immune Response Transforming Growth Factor Beta Binding Extracellular Region Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Elastic Fiber Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Inhibitor Activity Low-density Lipoprotein Particle Receptor Binding Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Presynaptic Cytosol Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Population Proliferation Regulation Of Extracellular Matrix Organization Regulation Of Alternative MRNA Splicing, Via Spliceosome	Protein Kinase Activity Kinase Activity Protein Tyrosine Kinase Activity ATP Binding Enzyme-linked Receptor Protein Signaling Pathway Protein Phosphorylation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Phosphorylation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Surface Receptor Signaling Pathway Response To Growth Factor Positive Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Activity Nucleotide Binding Cellular Response To Growth Factor Stimulus Regulation Of Cell Communication Regulation Of Signaling Regulation Of MAPK Cascade Transferase Activity Intracellular Signal Transduction Receptor Complex Negative Regulation Of Apoptotic Process Positive Regulation Of Epithelial Cell Proliferation Cell Migration Negative Regulation Of Programmed Cell Death Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Intracellular Signaling Cassette Positive Regulation Of MAPK Cascade Protein Serine Kinase Activity Protein Autophosphorylation Regulation Of Apoptotic Process Cell Motility Regulation Of Protein Localization Regulation Of Epithelial Cell Proliferation Regulation Of Programmed Cell Death Cell-cell Junction Protein Serine/threonine Kinase Activity Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Peptidyl-tyrosine Phosphorylation Plasma Membrane Positive Regulation Of Protein Localization Protein Kinase Binding Regulation Of Developmental Process Positive Regulation Of Cell Population Proliferation Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Component Organization
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