HECW1 and UBE2J2

Number of citations of the paper that reports this interaction (PubMedID 26949039)
63

Data Source:
BioGRID (pull down)

		HECW1	UBE2J2
Description		HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	ubiquitin conjugating enzyme E2 J2
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GO Annotations	Cellular Component	Cytoplasm Cytosol	Ubiquitin Ligase Complex Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin Protein Ligase Activity	Nucleotide Binding Protein Binding ATP Binding Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Regulation Of Dendrite Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Response To Unfolded Protein Protein Ubiquitination ERAD Pathway Protein K6-linked Ubiquitination Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		Degradation of DVL	E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Bone mineral density (Ward's triangle area) ( 27397699) Caudal anterior-cingulate cortex volume ( 31530798) Cerebrospinal fluid AB1-42 levels ( 26252872) Delirium ( 29631748) Diverticular disease ( 28585551) Irritable bowel syndrome ( 29673008) Lung cancer in ever smokers ( 28604730) Mercury levels ( 26025379) Obesity-related traits ( 23251661) Serum galactose-deficient IgA1 levels ( 28187132) Type 2 diabetes ( 25102180)	Inflammatory bowel disease ( 28067908) Systemic lupus erythematosus ( 28714469) Ulcerative colitis ( 28067908)
Interacting Genes		19 interacting genes: CACNA1A DVL1 GFI1B PRRG4 SCNN1A SCNN1B SHANK3 SSR4 TNK2 TP53 TSC1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2J2 UBE2L3 USP7 VAX1	22 interacting genes: AQP6 ATP13A2 ELOVL7 FBXO7 HECW1 HERC4 ITCH MARCHF6 MDM2 MGRN1 NEDD4L PRKN RBP1 RNF10 TMEM14B TRIM25 TRIM59 UBA1 UBC UBE2G2 WWP2 XIAP
Entrez ID		23072	118424
HPRD ID		11385	15600
Ensembl ID		ENSG00000002746	ENSG00000160087
Uniprot IDs		Q76N89	A6NGS0 Q8N2K1
PDB IDs		3L4H	2F4W
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity WW Domain Binding Protein Ubiquitination Sensory Perception Of Salty Taste Protein Modification By Small Protein Conjugation Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Protein Polyubiquitination Cellular Response To Aldosterone Sodium Channel Complex Ubiquitin Protein Ligase Binding Post-translational Protein Modification Proteolysis Modification-dependent Protein Catabolic Process Regulation Of Protein Targeting To Mitochondrion Sensory Perception Of Sour Taste Cellular Response To Vasopressin TORC1 Signaling Cellular Response To Corticosteroid Stimulus Negative Regulation Of TORC1 Signaling Proteolysis Involved In Protein Catabolic Process Cellular Response To Mineralocorticoid Stimulus Ligand-gated Sodium Channel Activity Negative Regulation Of ATP-dependent Activity Negative Regulation Of Neuroblast Proliferation Cellular Response To Steroid Hormone Stimulus TOR Signaling Protein Stabilization Negative Regulation Of TOR Signaling Inorganic Cation Import Across Plasma Membrane Response To Nutrient Levels Ubiquitin-protein Transferase Activity Response To Aldosterone Cellular Response To Nutrient Levels Regulation Of TORC1 Signaling Dendritic Spine Morphogenesis Cellular Response To Acidic PH Negative Regulation Of Autophagy Protein K48-linked Ubiquitination Intracellular Sodium Ion Homeostasis Ubiquitin-dependent Protein Catabolic Process Sodium Ion Import Across Plasma Membrane Response To Acidic PH Protein K6-linked Ubiquitination Cellular Response To PH Negative Regulation Of Neural Precursor Cell Proliferation Multicellular Organismal-level Water Homeostasis Import Across Plasma Membrane Positive Regulation Of Excitatory Postsynaptic Potential Dendritic Spine Organization	Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Post-translational Protein Modification Modification-dependent Protein Catabolic Process Ubiquitin Protein Ligase Activity Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Macromolecule Catabolic Process Protein Modification Process Proteolysis Catabolic Process Protein K48-linked Ubiquitination Protein Monoubiquitination Proteasomal Protein Catabolic Process Transferase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Protein Metabolic Process Protein Autoubiquitination Macromolecule Metabolic Process Positive Regulation Of Protein Linear Polyubiquitination Protein K63-linked Ubiquitination Negative Regulation Of Signal Transduction ERAD Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Ubiquitin Ligase Complex Ligase Activity Negative Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Autophagy Of Mitochondrion Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Manganese Ion Potassium Channel Inhibitor Activity Response To Oxidative Stress Protein K29-linked Ubiquitination Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Protein Catabolic Process Regulation Of Protein Localization Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Response To Manganese Ion Positive Regulation Of Protein Catabolic Process Cellular Response To Oxidative Stress Negative Regulation Of Protein Localization Regulation Of Protein Transport Response To Endoplasmic Reticulum Stress Positive Regulation Of Protein Polyubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Exosomal Secretion
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