HECW1 and SSR4

Number of citations of the paper that reports this interaction (PubMedID 14684739)
0

Data Source:
HPRD (two hybrid, in vitro)

		HECW1	SSR4
Description		HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	signal sequence receptor subunit 4
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GO Annotations	Cellular Component	Cytoplasm Cytosol	Endoplasmic Reticulum Sec61 Translocon Complex Endoplasmic Reticulum Membrane Endomembrane System Membrane Extracellular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Regulation Of Dendrite Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		Degradation of DVL	SRP-dependent cotranslational protein targeting to membrane
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Bone mineral density (Ward's triangle area) ( 27397699) Caudal anterior-cingulate cortex volume ( 31530798) Cerebrospinal fluid AB1-42 levels ( 26252872) Delirium ( 29631748) Diverticular disease ( 28585551) Irritable bowel syndrome ( 29673008) Lung cancer in ever smokers ( 28604730) Mercury levels ( 26025379) Obesity-related traits ( 23251661) Serum galactose-deficient IgA1 levels ( 28187132) Type 2 diabetes ( 25102180)
Interacting Genes		19 interacting genes: CACNA1A DVL1 GFI1B PRRG4 SCNN1A SCNN1B SHANK3 SSR4 TNK2 TP53 TSC1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2J2 UBE2L3 USP7 VAX1	5 interacting genes: HECW1 NLGN3 POMP PTEN SSR3
Entrez ID		23072	6748
HPRD ID		11385	02101
Ensembl ID		ENSG00000002746	ENSG00000180879
Uniprot IDs		Q76N89	P51571
PDB IDs		3L4H	8B6L
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity WW Domain Binding Protein Ubiquitination Sensory Perception Of Salty Taste Protein Modification By Small Protein Conjugation Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Protein Polyubiquitination Cellular Response To Aldosterone Sodium Channel Complex Ubiquitin Protein Ligase Binding Post-translational Protein Modification Proteolysis Modification-dependent Protein Catabolic Process Regulation Of Protein Targeting To Mitochondrion Sensory Perception Of Sour Taste Cellular Response To Vasopressin TORC1 Signaling Cellular Response To Corticosteroid Stimulus Negative Regulation Of TORC1 Signaling Proteolysis Involved In Protein Catabolic Process Cellular Response To Mineralocorticoid Stimulus Ligand-gated Sodium Channel Activity Negative Regulation Of ATP-dependent Activity Negative Regulation Of Neuroblast Proliferation Cellular Response To Steroid Hormone Stimulus TOR Signaling Protein Stabilization Negative Regulation Of TOR Signaling Inorganic Cation Import Across Plasma Membrane Response To Nutrient Levels Ubiquitin-protein Transferase Activity Response To Aldosterone Cellular Response To Nutrient Levels Regulation Of TORC1 Signaling Dendritic Spine Morphogenesis Cellular Response To Acidic PH Negative Regulation Of Autophagy Protein K48-linked Ubiquitination Intracellular Sodium Ion Homeostasis Ubiquitin-dependent Protein Catabolic Process Sodium Ion Import Across Plasma Membrane Response To Acidic PH Protein K6-linked Ubiquitination Cellular Response To PH Negative Regulation Of Neural Precursor Cell Proliferation Multicellular Organismal-level Water Homeostasis Import Across Plasma Membrane Positive Regulation Of Excitatory Postsynaptic Potential Dendritic Spine Organization	Rhythmic Synaptic Transmission Presynaptic Membrane Organization Presynaptic Membrane Assembly Positive Regulation Of Excitatory Postsynaptic Potential Social Behavior Membrane Assembly Modulation Of Excitatory Postsynaptic Potential Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Synapse Assembly Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Positive Regulation Of Cardiolipin Metabolic Process Regulation Of Nervous System Process Central Nervous System Myelin Maintenance Symmetric, GABA-ergic, Inhibitory Synapse Regulation Of Plasma Membrane Bounded Cell Projection Organization Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Regulation Of Cell Projection Organization Adult Behavior Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Phosphatidylinositol Phosphate Phosphatase Activity Membrane Organization Regulation Of Cardiolipin Metabolic Process Cardiolipin Acyl-chain Remodeling Asymmetric, Glutamatergic, Excitatory Synapse Locomotor Rhythm Regulation Of Cell Junction Assembly Cognition Cell Junction Assembly Chemical Synaptic Transmission Phosphatidylinositol-3-phosphate Phosphatase Activity Cellular Response To Electrical Stimulus Learning Or Memory Ubiquitin Ligase Activator Activity Spindle Assembly Involved In Female Meiosis Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Synaptic Vesicle Clustering Glycerolipid Metabolic Process Postsynaptic Specialization Assembly Prepulse Inhibition Neuron-neuron Synaptic Transmission Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Anatomical Structure Morphogenesis Meiotic Spindle Assembly Synapse Maturation Negative Regulation Of Cell Size Maternal Behavior
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