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HECW1 and TNK2
Number of citations of the paper that reports this interaction (PMID
19144635
)
19
Data Source:
BioGRID
(pull down)
HECW1
TNK2
Gene Name
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
tyrosine kinase, non-receptor, 2
Image
Gene Ontology Annotations
Cellular Component
Cytosol
Nucleus
Cytoplasm
Endosome
Plasma Membrane
Coated Pit
Adherens Junction
Membrane
Clathrin-coated Vesicle
Axon
Dendrite
Growth Cone
Cytoplasmic Vesicle Membrane
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Neuronal Cell Body
Grb2-EGFR Complex
Molecular Function
Ubiquitin-protein Transferase Activity
Ligase Activity
Protein Serine/threonine Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
GTPase Inhibitor Activity
Epidermal Growth Factor Receptor Binding
Protein Binding
ATP Binding
Metal Ion Binding
WW Domain Binding
Hormone Receptor Binding
Biological Process
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Canonical Wnt Signaling Pathway
Endocytosis
Cell Surface Receptor Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Small GTPase Mediated Signal Transduction
Phosphorylation
Cell Migration
Cell Differentiation
Peptidyl-tyrosine Autophosphorylation
Regulation Of Cell Proliferation
Negative Regulation Of Catalytic Activity
Innate Immune Response
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Regulation Of Clathrin-mediated Endocytosis
Pathways
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
TCF dependent signaling in response to WNT
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
degradation of DVL
Signaling by Wnt
Signaling by WNT in cancer
Drugs
Adenosine triphosphate
Debromohymenialdisine
Diseases
GWAS
Alzheimer's disease (cognitive decline) (
23535033
)
Obesity-related traits (
23251661
)
Protein-Protein Interactions
10 interactors:
CACNA1A
DVL1
GFI1B
SCNN1A
SCNN1B
SSR4
TNK2
TP53
UBC
USP7
41 interactors:
AQP1
AR
ARSE
BAG3
CDC42
CLTC
CSPG4
CTTN
EGFR
FYN
GALT
GRB2
HCK
HECW1
HSH2D
HSP90AB2P
ITFG2
KCNA5
KRTAP10-3
MAGI3
MCF2
MERTK
NCK1
NEK6
NOTCH2NL
NPHP1
RASGEF1C
RASGRF1
RPL18A
SEZ6
SH2D1A
SIAH1
SMURF1
SNX9
SRC
SRSF5
VTI1B
WAS
WWOX
WWP2
YES1
Entrez ID
23072
10188
HPRD ID
11385
06104
Ensembl ID
ENSG00000061938
Uniprot IDs
B4DH42
Q76N89
B3KXJ4
C9J1X3
Q07912
PDB IDs
3L4H
1CF4
1U46
1U4D
1U54
3EQP
3EQR
4EWH
4HZR
4HZS
4ID7
Enriched GO Terms of Interacting Partners
?
Membrane Organization
Sodium Ion Homeostasis
Regulation Of Cellular Protein Metabolic Process
Regulation Of Protein Metabolic Process
Transport
Excretion
Multicellular Organismal Water Homeostasis
Negative Regulation Of Catalytic Activity
Receptor Clustering
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint
Signal Transduction Involved In DNA Damage Checkpoint
Signal Transduction Involved In Cell Cycle Checkpoint
Water Homeostasis
Sensory Perception Of Taste
Transcription From RNA Polymerase II Promoter
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Mitotic G1 DNA Damage Checkpoint
Mitotic G1/S Transition Checkpoint
G1 DNA Damage Checkpoint
Protein Localization To Membrane
Positive Regulation Of Cell Cycle Arrest
Cerebellar Molecular Layer Development
DNA Damage Response, Signal Transduction By P53 Class Mediator
Regulation Of Protein Catabolic Process
Dendrite Morphogenesis
Regulation Of Cellular Component Organization
Signal Transduction In Response To DNA Damage
Regulation Of Protein Phosphorylation
Nucleotide-excision Repair
Mitotic DNA Damage Checkpoint
Regulation Of Cell Cycle Arrest
Establishment Of Localization In Cell
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Cellular Response To Hypoxia
Mitotic DNA Integrity Checkpoint
Cellular Response To Decreased Oxygen Levels
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Metal Ion Homeostasis
Negative Regulation Of Macromitophagy
Vestibular Nucleus Development
Oligodendrocyte Apoptotic Process
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Negative Regulation Of Cellular Metabolic Process
Neurological System Process
Neurotransmitter Secretion
Growth
Cellular Response To Oxygen Levels
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Fc-gamma Receptor Signaling Pathway
Fc Receptor Mediated Stimulatory Signaling Pathway
Regulation Of Signaling
Regulation Of Signal Transduction
Phagocytosis
Endocytosis
Fc Receptor Signaling Pathway
Signaling
Positive Regulation Of Signal Transduction
Cell Communication
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Cell Differentiation
Developmental Process
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Cellular Component Organization
Neuron Development
Positive Regulation Of Cellular Component Biogenesis
Regulation Of Apoptotic Process
Anatomical Structure Development
Neuron Projection Development
Locomotion
Immune Response-regulating Signaling Pathway
Cell Migration
Regulation Of Cell Death
Leukocyte Migration
Regulation Of Cellular Process
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Motility
Enzyme Linked Receptor Protein Signaling Pathway
Response To Stimulus
Neuron Differentiation
T Cell Costimulation
Cell Projection Organization
Neurogenesis
Axon Guidance
Nervous System Development
Vesicle-mediated Transport
Positive Regulation Of Protein Complex Assembly
Regulation Of Intracellular Signal Transduction
Movement Of Cell Or Subcellular Component
System Development
Positive Regulation Of Intracellular Signal Transduction
Peptidyl-tyrosine Autophosphorylation
Generation Of Neurons
Neuron Projection Morphogenesis
Cellular Response To Platelet-derived Growth Factor Stimulus
Multicellular Organismal Development
Positive Regulation Of Immune Response
Negative Regulation Of Signal Transduction
Tagcloud
?
ack1
acquire
addiction
cdc42
demethylase
deprivation
deregulated
doi
explosion
facets
fuel
functionality
genotoxic
hoxa1
insults
jhdm2a
kdm3a
modifies
onc
publication
reality
rtk
rtks
shuttles
soon
transduce
uncovered
unfold
wherein
Tagcloud (Difference)
?
ack1
acquire
addiction
cdc42
demethylase
deprivation
deregulated
doi
explosion
facets
fuel
functionality
genotoxic
hoxa1
insults
jhdm2a
kdm3a
modifies
onc
publication
reality
rtk
rtks
shuttles
soon
transduce
uncovered
unfold
wherein
Tagcloud (Intersection)
?