CACNA1A and TSPAN7

Number of citations of the paper that reports this interaction (PubMedID 21078624)
125

Data Source:
BioGRID (two hybrid)

		CACNA1A	TSPAN7
Description		calcium voltage-gated channel subunit alpha1 A	tetraspanin 7
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Voltage-gated Calcium Channel Complex Membrane Monoatomic Ion Channel Complex Cell Projection Neuronal Cell Body Synapse	Plasma Membrane Membrane
	Molecular Function	Amyloid-beta Binding Monoatomic Ion Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity Syntaxin Binding Metal Ion Binding	Protein Binding
	Biological Process	Monoatomic Ion Transport Calcium Ion Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport Modulation Of Chemical Synaptic Transmission Transmembrane Transport Calcium Ion Transmembrane Transport Calcium Ion Import Across Plasma Membrane Response To Amyloid-beta Cellular Response To Amyloid-beta
Pathways		Presynaptic depolarization and calcium channel opening Regulation of insulin secretion	Cell surface interactions at the vascular wall Trafficking of GluR2-containing AMPA receptors
Drugs		Ergocalciferol Enflurane Phenytoin Spironolactone Nicardipine Magnesium sulfate Verapamil Verapamil Levomenthol Loperamide Nitrendipine Bepridil Ziconotide Dotarizine Drotaverine Trimebutine Benidipine Cilnidipine Efonidipine Lacidipine Manidipine Butamben Bioallethrin Bioallethrin Bioallethrin
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3) Episodic ataxias Familial or sporadic hemiplegic migraine	Non-syndromic X-linked mental retardation
GWAS		Exfoliation syndrome ( 25706626) Proteinuria and chronic kidney disease ( 26420894)	White blood cell count ( 32888494)
Interacting Genes		92 interacting genes: ABCA2 ABI1 ACTN1 ADGRL1 AGRN ALDOA AMIGO2 AP2M1 ARHGAP22 BTG3 C1QTNF1 CABP1 CACNB1 CACNB4 CALM2 CALM3 CKAP5 CRIM1 CRMP1 CSNK2B CYSRT1 DNAJB5 EFEMP1 EFEMP2 EHMT2 EIF3A FBLN1 GET3 GNB1 GOLGA6L5P GRN HECW1 HHATL HIVEP1 HSPG2 IP6K1 JAG2 KALRN KHDRBS3 KIAA1191 LAMB1 LLGL1 LRP1 LTBP1 LTBP3 LTBP4 MANBAL MATK MATN2 MEGF6 MEGF8 MIA3 MOAP1 NDUFB8 NELFCD NELL1 NELL2 NOTCH1 NOXA1 OLIG1 PCSK5 PCSK6 PMM1 PPIG PPM1A PPP1R12C PTGDS PUF60 RBM12B RIMBP2 RPL31 RPS17 SCP2 SPRY1 SRRM4 SRSF1 SUMF2 SYT1 TAF15 TELO2 TSC22D1 TSPAN7 TSPOAP1 TUBB2B UQCRC2 VARS1 VPS52 VWF WBP1 YLPM1 ZCCHC17 ZNF233	27 interacting genes: ADRB2 BBS1 BTG3 BUD31 CACNA1A CCR2 CCR9 CHRM2 CHRM4 CREB3 DRD2 FAM209A FYTTD1 GNRHR GPR152 GPR35 GRIA2 GRIA3 HTR4 ITGB1 LHFPL5 LMNA LTB4R2 MEOX2 OXTR PICK1 SMO
Entrez ID		773	7102
HPRD ID		03004	02107
Ensembl ID		ENSG00000141837	ENSG00000156298
Uniprot IDs		A0A087WW63 B5TYJ1 O00555 Q9NS89	P41732
PDB IDs		3BXK 8X90 8X91 8X93
Enriched GO Terms of Interacting Partners?		Calcium Ion Binding Extracellular Matrix Structural Constituent Extracellular Matrix Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Embryo Implantation Calcium Channel Regulator Activity Basement Membrane Microfibril Voltage-gated Calcium Channel Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Levels Detection Of Calcium Ion Auditory Receptor Cell Fate Commitment Protein Binding Calyx Of Held Integrin Binding Astrocyte Activation Involved In Immune Response Transforming Growth Factor Beta Binding Extracellular Region Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Elastic Fiber Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Inhibitor Activity Low-density Lipoprotein Particle Receptor Binding Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Presynaptic Cytosol Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Population Proliferation Regulation Of Extracellular Matrix Organization Regulation Of Alternative MRNA Splicing, Via Spliceosome	G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway Modulation Of Chemical Synaptic Transmission Anatomical Structure Homeostasis Tissue Homeostasis Regulation Of Biological Quality Chemical Synaptic Transmission Plasma Membrane Trans-synaptic Signaling Synaptic Signaling Cell-cell Signaling Signaling Endocytic Vesicle Membrane Cell Communication Dendrite Chemokine Receptor Activity Multicellular Organismal-level Homeostasis Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Amyloid-beta Binding Positive Regulation Of Neuroblast Proliferation Ionotropic Glutamate Receptor Signaling Pathway Neural Precursor Cell Proliferation G Protein-coupled Acetylcholine Receptor Activity Regulation Of Locomotion Postsynaptic Membrane Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Membrane Positive Regulation Of Neurotransmitter Uptake AMPA Glutamate Receptor Activity Ligand-gated Ion Channel Signaling Pathway Regulation Of Neuroblast Proliferation Neuroblast Proliferation Signal Transduction Patched Binding Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Cellular Defense Response Glutamate Receptor Signaling Pathway Synapse Positive Regulation Of Neural Precursor Cell Proliferation Ciliary Membrane G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Dendritic Spine Positive Regulation Of Cytosolic Calcium Ion Concentration Glutamate-gated Receptor Activity Negative Regulation Of Adenylate Cyclase Activity Cell Surface Receptor Signaling Pathway Regulation Of Multicellular Organism Growth Regulation Of Cell Motility Regulation Of System Process Cilium
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