CACNA1A and CABP1

Number of citations of the paper that reports this interaction (PubMedID 11865310)
39

Data Source:
HPRD (in vitro, in vivo)

		CACNA1A	CABP1
Description		calcium voltage-gated channel subunit alpha1 A	calcium binding protein 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Voltage-gated Calcium Channel Complex Membrane Monoatomic Ion Channel Complex Cell Projection Neuronal Cell Body Synapse	Golgi Membrane Extracellular Space Cytoplasm Golgi Apparatus Cytoskeleton Plasma Membrane Cell Cortex Postsynaptic Density Membrane Synapse Perinuclear Region Of Cytoplasm
	Molecular Function	Amyloid-beta Binding Monoatomic Ion Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity Syntaxin Binding Metal Ion Binding	Enzyme Inhibitor Activity Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Nuclear Localization Sequence Binding Metal Ion Binding Calcium-dependent Protein Binding
	Biological Process	Monoatomic Ion Transport Calcium Ion Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport Modulation Of Chemical Synaptic Transmission Transmembrane Transport Calcium Ion Transmembrane Transport Calcium Ion Import Across Plasma Membrane Response To Amyloid-beta Cellular Response To Amyloid-beta	Visual Perception Negative Regulation Of Protein Import Into Nucleus
Pathways		Presynaptic depolarization and calcium channel opening Regulation of insulin secretion	Sensory processing of sound by inner hair cells of the cochlea
Drugs		Ergocalciferol Enflurane Phenytoin Spironolactone Nicardipine Magnesium sulfate Verapamil Verapamil Levomenthol Loperamide Nitrendipine Bepridil Ziconotide Dotarizine Drotaverine Trimebutine Benidipine Cilnidipine Efonidipine Lacidipine Manidipine Butamben Bioallethrin Bioallethrin Bioallethrin
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3) Episodic ataxias Familial or sporadic hemiplegic migraine
GWAS		Exfoliation syndrome ( 25706626) Proteinuria and chronic kidney disease ( 26420894)	C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Chronotype ( 30696823) Serum metabolite levels ( 33031748) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Systemic lupus erythematosus ( 33536424)
Interacting Genes		92 interacting genes: ABCA2 ABI1 ACTN1 ADGRL1 AGRN ALDOA AMIGO2 AP2M1 ARHGAP22 BTG3 C1QTNF1 CABP1 CACNB1 CACNB4 CALM2 CALM3 CKAP5 CRIM1 CRMP1 CSNK2B CYSRT1 DNAJB5 EFEMP1 EFEMP2 EHMT2 EIF3A FBLN1 GET3 GNB1 GOLGA6L5P GRN HECW1 HHATL HIVEP1 HSPG2 IP6K1 JAG2 KALRN KHDRBS3 KIAA1191 LAMB1 LLGL1 LRP1 LTBP1 LTBP3 LTBP4 MANBAL MATK MATN2 MEGF6 MEGF8 MIA3 MOAP1 NDUFB8 NELFCD NELL1 NELL2 NOTCH1 NOXA1 OLIG1 PCSK5 PCSK6 PMM1 PPIG PPM1A PPP1R12C PTGDS PUF60 RBM12B RIMBP2 RPL31 RPS17 SCP2 SPRY1 SRRM4 SRSF1 SUMF2 SYT1 TAF15 TELO2 TSC22D1 TSPAN7 TSPOAP1 TUBB2B UQCRC2 VARS1 VPS52 VWF WBP1 YLPM1 ZCCHC17 ZNF233	9 interacting genes: CACNA1A CACNA1C CSNK2A2 FOS GRK5 ITPR1 ITPR3 NMT1 PPP3R1
Entrez ID		773	9478
HPRD ID		03004	12025
Ensembl ID		ENSG00000141837	ENSG00000157782
Uniprot IDs		A0A087WW63 B5TYJ1 O00555 Q9NS89	C9J8G2 Q9NZU7
PDB IDs		3BXK 8X90 8X91 8X93	2K7B 2K7C 2K7D 2LAN 2LAP 3OX5 3OX6
Enriched GO Terms of Interacting Partners?		Calcium Ion Binding Extracellular Matrix Structural Constituent Extracellular Matrix Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Embryo Implantation Calcium Channel Regulator Activity Basement Membrane Microfibril Voltage-gated Calcium Channel Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Levels Detection Of Calcium Ion Auditory Receptor Cell Fate Commitment Protein Binding Calyx Of Held Integrin Binding Astrocyte Activation Involved In Immune Response Transforming Growth Factor Beta Binding Extracellular Region Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Elastic Fiber Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Inhibitor Activity Low-density Lipoprotein Particle Receptor Binding Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Presynaptic Cytosol Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Population Proliferation Regulation Of Extracellular Matrix Organization Regulation Of Alternative MRNA Splicing, Via Spliceosome	Calcium Ion Transmembrane Import Into Cytosol Calcium Channel Activity Inositol 1,4,5-trisphosphate-gated Calcium Channel Activity Monoatomic Ion Channel Activity Calcium-mediated Signaling Calcium Ion Transmembrane Transport Calcineurin Complex Calcium Ion Transport Intracellularly Gated Calcium Channel Activity Platelet Dense Tubular Network Membrane Metal Ion Transport Inositol 1,4,5 Trisphosphate Binding High Voltage-gated Calcium Channel Activity Cytoplasm Monoatomic Cation Transport Regulation Of Sequestering Of Calcium Ion Calcium Ion Import Across Plasma Membrane Import Across Plasma Membrane Voltage-gated Calcium Channel Complex Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium Ion Import Into Cytosol Intracellular Signaling Cassette Monoatomic Ion Transport Voltage-gated Calcium Channel Activity Calcium Ion Import Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Transmembrane Transport Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Transport Vesicle Membrane Phosphatase Binding Wnt Signaling Pathway Medium-term Memory Cellular Response To Prolactin Release Of Sequestered Calcium Ion Into Cytosol Inositol 1,4,5-trisphosphate Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Levels Negative Regulation Of Sequestering Of Calcium Ion Myristoyltransferase Activity Renal Phosphate Ion Absorption Inorganic Ion Transmembrane Transport Protein Homotetramerization Sarcoplasmic Reticulum Monoatomic Ion Transmembrane Transport Positive Regulation Of Establishment Of Protein Localization Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Signal Transduction Regulation Of Metal Ion Transport Cerebral Cortex Development
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