CACNA1A and GOLGA6L5P

Number of citations of the paper that reports this interaction (PubMedID 21078624)
125

Data Source:
BioGRID (two hybrid)

		CACNA1A	GOLGA6L5P
Description		calcium voltage-gated channel subunit alpha1 A	golgin A6 family like 5, pseudogene
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Voltage-gated Calcium Channel Complex Membrane Monoatomic Ion Channel Complex Cell Projection Neuronal Cell Body Synapse
	Molecular Function	Amyloid-beta Binding Monoatomic Ion Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity Syntaxin Binding Metal Ion Binding
	Biological Process	Monoatomic Ion Transport Calcium Ion Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport Modulation Of Chemical Synaptic Transmission Transmembrane Transport Calcium Ion Transmembrane Transport Calcium Ion Import Across Plasma Membrane Response To Amyloid-beta Cellular Response To Amyloid-beta
Pathways		Presynaptic depolarization and calcium channel opening Regulation of insulin secretion
Drugs		Ergocalciferol Enflurane Phenytoin Spironolactone Nicardipine Magnesium sulfate Verapamil Verapamil Levomenthol Loperamide Nitrendipine Bepridil Ziconotide Dotarizine Drotaverine Trimebutine Benidipine Cilnidipine Efonidipine Lacidipine Manidipine Butamben Bioallethrin Bioallethrin Bioallethrin
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3) Episodic ataxias Familial or sporadic hemiplegic migraine
GWAS		Exfoliation syndrome ( 25706626) Proteinuria and chronic kidney disease ( 26420894)	Autism spectrum disorder or schizophrenia ( 28540026) Hip circumference adjusted for BMI ( 34021172) Schizophrenia ( 29483656) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		92 interacting genes: ABCA2 ABI1 ACTN1 ADGRL1 AGRN ALDOA AMIGO2 AP2M1 ARHGAP22 BTG3 C1QTNF1 CABP1 CACNB1 CACNB4 CALM2 CALM3 CKAP5 CRIM1 CRMP1 CSNK2B CYSRT1 DNAJB5 EFEMP1 EFEMP2 EHMT2 EIF3A FBLN1 GET3 GNB1 GOLGA6L5P GRN HECW1 HHATL HIVEP1 HSPG2 IP6K1 JAG2 KALRN KHDRBS3 KIAA1191 LAMB1 LLGL1 LRP1 LTBP1 LTBP3 LTBP4 MANBAL MATK MATN2 MEGF6 MEGF8 MIA3 MOAP1 NDUFB8 NELFCD NELL1 NELL2 NOTCH1 NOXA1 OLIG1 PCSK5 PCSK6 PMM1 PPIG PPM1A PPP1R12C PTGDS PUF60 RBM12B RIMBP2 RPL31 RPS17 SCP2 SPRY1 SRRM4 SRSF1 SUMF2 SYT1 TAF15 TELO2 TSC22D1 TSPAN7 TSPOAP1 TUBB2B UQCRC2 VARS1 VPS52 VWF WBP1 YLPM1 ZCCHC17 ZNF233	3 interacting genes: ATXN2 CACNA1A NOD2
Entrez ID		773	374650
HPRD ID		03004	13442
Ensembl ID		ENSG00000141837
Uniprot IDs		A0A087WW63 B5TYJ1 O00555 Q9NS89
PDB IDs		3BXK 8X90 8X91 8X93
Enriched GO Terms of Interacting Partners?		Calcium Ion Binding Extracellular Matrix Structural Constituent Extracellular Matrix Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Embryo Implantation Calcium Channel Regulator Activity Basement Membrane Microfibril Voltage-gated Calcium Channel Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Levels Detection Of Calcium Ion Auditory Receptor Cell Fate Commitment Protein Binding Calyx Of Held Integrin Binding Astrocyte Activation Involved In Immune Response Transforming Growth Factor Beta Binding Extracellular Region Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Elastic Fiber Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Inhibitor Activity Low-density Lipoprotein Particle Receptor Binding Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Presynaptic Cytosol Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Population Proliferation Regulation Of Extracellular Matrix Organization Regulation Of Alternative MRNA Splicing, Via Spliceosome	High Voltage-gated Calcium Channel Activity Positive Regulation Of Protein K63-linked Ubiquitination Detection Of Molecule Of Bacterial Origin Positive Regulation Of Gamma-delta T Cell Activation Detection Of Bacterium Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Detection Of Muramyl Dipeptide Detection Of Peptidoglycan Intestinal Stem Cell Homeostasis Cellular Response To Peptidoglycan Protein Linear Polyubiquitination Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Carbohydrate Derivative Binding Extrinsic Component Of Plasma Membrane Cellular Response To Muramyl Dipeptide Negative Regulation Of Macrophage Apoptotic Process Positive Regulation Of Dendritic Cell Cytokine Production Response To Peptidoglycan Muramyl Dipeptide Binding Anion Binding Host-mediated Modulation Of Intestinal Microbiota Composition Negative Regulation Of Receptor Internalization P-body Assembly Peptidoglycan Binding Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Dendritic Cell Cytokine Production Positive Regulation Of Stress-activated MAPK Cascade Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Type 2 Immune Response CARD Domain Binding Positive Regulation Of Protein Polyubiquitination Antibacterial Innate Immune Response Calcium Ion Import Across Plasma Membrane Voltage-gated Calcium Channel Complex Calcium Ion Import Into Cytosol Regulation Of Antigen Processing And Presentation Positive Regulation Of Mitophagy Maintenance Of Gastrointestinal Epithelium Response To Muramyl Dipeptide Negative Regulation Of Myeloid Cell Apoptotic Process Regulation Of Appetite P38MAPK Cascade Positive Regulation Of Interleukin-17 Production Positive Regulation Of Autophagy Of Mitochondrion Regulation Of Protein Polyubiquitination Voltage-gated Calcium Channel Activity Calcium Ion Import Stress Granule Assembly Epidermal Growth Factor Receptor Binding Negative Regulation Of Receptor-mediated Endocytosis
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