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CACNA1A and EFEMP2
Number of citations of the paper that reports this interaction (PubMedID
21078624
)
125
Data Source:
BioGRID
(two hybrid)
CACNA1A
EFEMP2
Description
calcium voltage-gated channel subunit alpha1 A
EGF-like fibulin extracellular matrix protein 2
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Plasma Membrane
Voltage-gated Calcium Channel Complex
Membrane
Monoatomic Ion Channel Complex
Cell Projection
Neuronal Cell Body
Synapse
Microfibril
Extracellular Region
Basement Membrane
Extracellular Matrix
Extracellular Exosome
Elastic Fiber
Extracellular Vesicle
Molecular Function
Amyloid-beta Binding
Monoatomic Ion Channel Activity
Voltage-gated Calcium Channel Activity
Calcium Channel Activity
Protein Binding
High Voltage-gated Calcium Channel Activity
Syntaxin Binding
Metal Ion Binding
Extracellular Matrix Structural Constituent
Calcium Ion Binding
Protein Binding
Heparin Binding
Protein Homodimerization Activity
Biological Process
Monoatomic Ion Transport
Calcium Ion Transport
Positive Regulation Of Cytosolic Calcium Ion Concentration
Chemical Synaptic Transmission
Monoatomic Ion Transmembrane Transport
Modulation Of Chemical Synaptic Transmission
Transmembrane Transport
Calcium Ion Transmembrane Transport
Calcium Ion Import Across Plasma Membrane
Response To Amyloid-beta
Cellular Response To Amyloid-beta
Aorta Development
Elastic Fiber Assembly
Aorta Smooth Muscle Tissue Morphogenesis
Artery Development
Vascular Associated Smooth Muscle Cell Development
Regulation Of Collagen Fibril Organization
Positive Regulation Of Collagen Fibril Organization
Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Aortic Smooth Muscle Cell Differentiation
Positive Regulation Of Smooth Muscle Cell-matrix Adhesion
Pathways
Presynaptic depolarization and calcium channel opening
Regulation of insulin secretion
Molecules associated with elastic fibres
Molecules associated with elastic fibres
Drugs
Ergocalciferol
Enflurane
Phenytoin
Spironolactone
Nicardipine
Magnesium sulfate
Verapamil
Verapamil
Levomenthol
Loperamide
Nitrendipine
Bepridil
Ziconotide
Dotarizine
Drotaverine
Trimebutine
Benidipine
Cilnidipine
Efonidipine
Lacidipine
Manidipine
Butamben
Bioallethrin
Bioallethrin
Bioallethrin
Diseases
Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
Episodic ataxias
Familial or sporadic hemiplegic migraine
Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome
GWAS
Exfoliation syndrome (
25706626
)
Proteinuria and chronic kidney disease (
26420894
)
Acne (severe) (
24927181
)
Adult body size (
32376654
)
Birth weight (
31043758
)
Body size at age 10 (
32376654
)
Monocyte count (
32888494
)
Retinal detachment or retinal break (
31816047
)
Interacting Genes
92 interacting genes:
ABCA2
ABI1
ACTN1
ADGRL1
AGRN
ALDOA
AMIGO2
AP2M1
ARHGAP22
BTG3
C1QTNF1
CABP1
CACNB1
CACNB4
CALM2
CALM3
CKAP5
CRIM1
CRMP1
CSNK2B
CYSRT1
DNAJB5
EFEMP1
EFEMP2
EHMT2
EIF3A
FBLN1
GET3
GNB1
GOLGA6L5P
GRN
HECW1
HHATL
HIVEP1
HSPG2
IP6K1
JAG2
KALRN
KHDRBS3
KIAA1191
LAMB1
LLGL1
LRP1
LTBP1
LTBP3
LTBP4
MANBAL
MATK
MATN2
MEGF6
MEGF8
MIA3
MOAP1
NDUFB8
NELFCD
NELL1
NELL2
NOTCH1
NOXA1
OLIG1
PCSK5
PCSK6
PMM1
PPIG
PPM1A
PPP1R12C
PTGDS
PUF60
RBM12B
RIMBP2
RPL31
RPS17
SCP2
SPRY1
SRRM4
SRSF1
SUMF2
SYT1
TAF15
TELO2
TSC22D1
TSPAN7
TSPOAP1
TUBB2B
UQCRC2
VARS1
VPS52
VWF
WBP1
YLPM1
ZCCHC17
ZNF233
133 interacting genes:
ADAMTSL4
AMMECR1
ANAPC11
AP1M1
APEX2
AQP1
ARRDC3
ATN1
ATXN1
ATXN7
BAG6
C3
C5orf24
CACNA1A
CATSPER1
CCDC33
CCND3
CCNK
CDPF1
CLPP
CNNM3
COL8A1
CREB5
CXCL5
CYSRT1
DGCR6
DOK7
DYRK1A
FAM107A
FAM110A
FAM124B
FAM74A4
FAM90A1
FBXW5
FTO
FXR1
GFI1B
GLRX3
HDAC4
HHEX
HHIPL1
HOXA1
HPCAL1
HSD3B7
HSPA12B
HSPBP1
IGFBP6
IL16
INCA1
ITGB5
KLF1
KRTAP10-8
KRTAP11-1
KRTAP12-2
KRTAP13-3
KRTAP19-5
KRTAP26-1
KRTAP3-2
LBX1
LCE1A
LCE1C
LCE1E
LCE2C
LCE2D
LCE3A
LCE3C
LCE3D
LCE3E
LINGO1
LNX1
MDFI
MEOX2
MRPL12
MXI1
NEDD4L
NOS3
NR1D2
NTM
NUFIP2
OTX1
P2RX7
PIDD1
PITX1
PLSCR1
PLSCR4
PROP1
PRPF31
PRR32
PTGER3
RAB40B
RBAK
RBP3
RBPMS
RERE
RHOXF2
RHPN1
RIBC2
RNF138
SGTA
SGTB
SHANK3
SLC16A5
SLC23A1
SLC25A48
SPACA9
SPATA24
SPATA3
SPATA8
SPRY4
STK16
TCAF1
THAP7
TLE5
TLX3
TP53
TRIB3
TRIM42
UBQLN1
UBQLN4
USP21
ZNF263
ZNF345
ZNF426
ZNF558
ZNF57
ZNF581
ZNF587
ZNF638
ZNF670
ZNF699
ZNF768
ZNF774
ZNF837
Entrez ID
773
30008
HPRD ID
03004
05221
Ensembl ID
ENSG00000141837
ENSG00000172638
Uniprot IDs
A0A087WW63
B5TYJ1
O00555
Q9NS89
O95967
Q9H3D5
PDB IDs
3BXK
8X90
8X91
8X93
2KL7
Enriched GO Terms of Interacting Partners
?
Calcium Ion Binding
Extracellular Matrix Structural Constituent
Extracellular Matrix
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Embryo Implantation
Calcium Channel Regulator Activity
Basement Membrane
Microfibril
Voltage-gated Calcium Channel Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Levels
Detection Of Calcium Ion
Auditory Receptor Cell Fate Commitment
Protein Binding
Calyx Of Held
Integrin Binding
Astrocyte Activation Involved In Immune Response
Transforming Growth Factor Beta Binding
Extracellular Region
Negative Regulation Of Calcium Ion Export Across Plasma Membrane
Adenylate Cyclase Activator Activity
Elastic Fiber
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Enzyme Inhibitor Activity
Low-density Lipoprotein Particle Receptor Binding
Transporter Inhibitor Activity
Regulation Of Calcium Ion Export Across Plasma Membrane
Presynaptic Cytosol
Regulation Of Cellular Response To Growth Factor Stimulus
Negative Regulation Of Cell Population Proliferation
Regulation Of Extracellular Matrix Organization
Regulation Of Alternative MRNA Splicing, Via Spliceosome
Protein Binding
Keratinization
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Epidermis Development
Regulation Of Transcription By RNA Polymerase II
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Identical Protein Binding
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
DNA Binding
Regulation Of RNA Metabolic Process
CD4 Receptor Binding
Regulation Of Primary Metabolic Process
Tissue Development
Regulation Of Nucleobase-containing Compound Metabolic Process
TRC Complex
Post-translational Protein Targeting To Endoplasmic Reticulum Membrane
Nucleus
Sequence-specific Double-stranded DNA Binding
Intermediate Filament
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of ERAD Pathway
Zinc Ion Binding
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