HECW1 and PRRG4

Number of citations of the paper that reports this interaction (PubMedID 23873930)
23

Data Source:
BioGRID (pull down)

		HECW1	PRRG4
Description		HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	proline rich and Gla domain 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Extracellular Region Extracellular Space Plasma Membrane Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin Protein Ligase Activity	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding WW Domain Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Regulation Of Dendrite Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway	Proteolysis Blood Coagulation
Pathways		Degradation of DVL
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Bone mineral density (Ward's triangle area) ( 27397699) Caudal anterior-cingulate cortex volume ( 31530798) Cerebrospinal fluid AB1-42 levels ( 26252872) Delirium ( 29631748) Diverticular disease ( 28585551) Irritable bowel syndrome ( 29673008) Lung cancer in ever smokers ( 28604730) Mercury levels ( 26025379) Obesity-related traits ( 23251661) Serum galactose-deficient IgA1 levels ( 28187132) Type 2 diabetes ( 25102180)	Parkinson's disease (age of onset) ( 19772629) Platelet count ( 32888494) Plateletcrit ( 32888494)
Interacting Genes		19 interacting genes: CACNA1A DVL1 GFI1B PRRG4 SCNN1A SCNN1B SHANK3 SSR4 TNK2 TP53 TSC1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2J2 UBE2L3 USP7 VAX1	30 interacting genes: ABL2 AOC3 ARHGEF7 BCL10 ERBB3 ERBB4 FYN GRAP GRB2 HCK HDAC1 HECW1 HLA-C ITCH ITSN1 LYN MAGI2 MAGI3 NEBL NEDD4 OSTF1 PEX13 RBBP8 TEC UBE2K VAV2 VEGFA WWP1 WWTR1 YAP1
Entrez ID		23072	79056
HPRD ID		11385	15187
Ensembl ID		ENSG00000002746	ENSG00000135378
Uniprot IDs		Q76N89	A0A0S2Z5M6 A0A0S2Z5N9 Q9BZD6
PDB IDs		3L4H
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity WW Domain Binding Protein Ubiquitination Sensory Perception Of Salty Taste Protein Modification By Small Protein Conjugation Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Protein Polyubiquitination Cellular Response To Aldosterone Sodium Channel Complex Ubiquitin Protein Ligase Binding Post-translational Protein Modification Proteolysis Modification-dependent Protein Catabolic Process Regulation Of Protein Targeting To Mitochondrion Sensory Perception Of Sour Taste Cellular Response To Vasopressin TORC1 Signaling Cellular Response To Corticosteroid Stimulus Negative Regulation Of TORC1 Signaling Proteolysis Involved In Protein Catabolic Process Cellular Response To Mineralocorticoid Stimulus Ligand-gated Sodium Channel Activity Negative Regulation Of ATP-dependent Activity Negative Regulation Of Neuroblast Proliferation Cellular Response To Steroid Hormone Stimulus TOR Signaling Protein Stabilization Negative Regulation Of TOR Signaling Inorganic Cation Import Across Plasma Membrane Response To Nutrient Levels Ubiquitin-protein Transferase Activity Response To Aldosterone Cellular Response To Nutrient Levels Regulation Of TORC1 Signaling Dendritic Spine Morphogenesis Cellular Response To Acidic PH Negative Regulation Of Autophagy Protein K48-linked Ubiquitination Intracellular Sodium Ion Homeostasis Ubiquitin-dependent Protein Catabolic Process Sodium Ion Import Across Plasma Membrane Response To Acidic PH Protein K6-linked Ubiquitination Cellular Response To PH Negative Regulation Of Neural Precursor Cell Proliferation Multicellular Organismal-level Water Homeostasis Import Across Plasma Membrane Positive Regulation Of Excitatory Postsynaptic Potential Dendritic Spine Organization	Signal Transduction Intracellular Signal Transduction Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Phosphotyrosine Residue Binding Peptidyl-tyrosine Phosphorylation Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Signal Transduction Positive Regulation Of Immune System Process Fc Receptor Mediated Stimulatory Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Immune Response Immune Response-activating Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Protein Modification Process Epidermal Growth Factor Receptor Binding Fc-gamma Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Activation Of Immune Response Regulation Of Cell Communication Regulation Of Signaling Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response Cytoplasm Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Fc Receptor Signaling Pathway Regulation Of Immune Response Proline-rich Region Binding Epidermal Growth Factor Receptor Signaling Pathway Cytosol Antigen Receptor-mediated Signaling Pathway Regulation Of Cell Adhesion Plasma Membrane Neuregulin Receptor Activity Regulation Of Neuron Projection Development Regulation Of Immune System Process Protein Ubiquitination ERBB Signaling Pathway Regulation Of Cell Activation Adaptive Immune Response Positive Regulation Of Defense Response Receptor-mediated Endocytosis Negative Regulation Of Apoptotic Process
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