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HECW1 and SCNN1B
Number of citations of the paper that reports this interaction (PubMedID
11244092
)
0
Data Source:
BioGRID
(far western blotting)
HECW1
SCNN1B
Description
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
sodium channel epithelial 1 subunit beta
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Plasma Membrane
External Side Of Plasma Membrane
Membrane
Apical Plasma Membrane
Cytoplasmic Vesicle Membrane
Cytoplasmic Vesicle
Sodium Channel Complex
Extracellular Exosome
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Transferase Activity
Ubiquitin Protein Ligase Activity
Sodium Channel Activity
Protein Binding
Ligand-gated Sodium Channel Activity
WW Domain Binding
Biological Process
Ubiquitin-dependent Protein Catabolic Process
Protein Ubiquitination
Regulation Of Dendrite Morphogenesis
Negative Regulation Of Canonical Wnt Signaling Pathway
Leukocyte Activation Involved In Inflammatory Response
Neutrophil Activation Involved In Immune Response
Renal System Process
Monoatomic Ion Transport
Sodium Ion Transport
Intracellular Sodium Ion Homeostasis
Regulation Of Blood Pressure
Response To Xenobiotic Stimulus
Gene Expression
Artery Smooth Muscle Contraction
Response To Food
Aldosterone Metabolic Process
Erythrocyte Homeostasis
Monoatomic Ion Transmembrane Transport
Multicellular Organism Growth
Sodium Ion Transmembrane Transport
Epithelial Fluid Transport
Multicellular Organismal-level Water Homeostasis
Sensory Perception Of Salty Taste
Sensory Perception Of Sour Taste
Potassium Ion Homeostasis
Sodium Ion Homeostasis
Mucus Secretion
Neutrophil-mediated Killing Of Bacterium
Cellular Response To Acidic PH
Sodium Ion Import Across Plasma Membrane
Cellular Response To Aldosterone
Cellular Response To Vasopressin
Pathways
Degradation of DVL
Stimuli-sensing channels
Sensory perception of salty taste
Drugs
Triamterene
Amiloride
Diseases
Liddle syndrome
Bronchiectasis with or without elevated sweat chloride
Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome)
GWAS
Alzheimer's disease (cognitive decline) (
23535033
)
Bone mineral density (Ward's triangle area) (
27397699
)
Caudal anterior-cingulate cortex volume (
31530798
)
Cerebrospinal fluid AB1-42 levels (
26252872
)
Delirium (
29631748
)
Diverticular disease (
28585551
)
Irritable bowel syndrome (
29673008
)
Lung cancer in ever smokers (
28604730
)
Mercury levels (
26025379
)
Obesity-related traits (
23251661
)
Serum galactose-deficient IgA1 levels (
28187132
)
Type 2 diabetes (
25102180
)
Kidney stones (
31729369
)
Interacting Genes
19 interacting genes:
CACNA1A
DVL1
GFI1B
PRRG4
SCNN1A
SCNN1B
SHANK3
SSR4
TNK2
TP53
TSC1
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2J2
UBE2L3
USP7
VAX1
14 interacting genes:
ANK3
CNTN1
COMMD10
EPN1
HECW1
ITCH
NEDD4
NEDD4L
NFASC
SCNN1A
SCNN1D
SCNN1G
STX1A
WWP2
Entrez ID
23072
6338
HPRD ID
11385
02861
Ensembl ID
ENSG00000002746
ENSG00000168447
Uniprot IDs
Q76N89
B2R812
H3BQ95
P51168
PDB IDs
3L4H
6BQN
6WTH
9BLR
9BTG
9BTU
Enriched GO Terms of Interacting Partners
?
Ubiquitin Conjugating Enzyme Activity
WW Domain Binding
Protein Ubiquitination
Sensory Perception Of Salty Taste
Protein Modification By Small Protein Conjugation
Positive Regulation Of Protein Targeting To Mitochondrion
Positive Regulation Of Establishment Of Protein Localization To Mitochondrion
Protein Polyubiquitination
Cellular Response To Aldosterone
Sodium Channel Complex
Ubiquitin Protein Ligase Binding
Post-translational Protein Modification
Proteolysis
Modification-dependent Protein Catabolic Process
Regulation Of Protein Targeting To Mitochondrion
Sensory Perception Of Sour Taste
Cellular Response To Vasopressin
TORC1 Signaling
Cellular Response To Corticosteroid Stimulus
Negative Regulation Of TORC1 Signaling
Proteolysis Involved In Protein Catabolic Process
Cellular Response To Mineralocorticoid Stimulus
Ligand-gated Sodium Channel Activity
Negative Regulation Of ATP-dependent Activity
Negative Regulation Of Neuroblast Proliferation
Cellular Response To Steroid Hormone Stimulus
TOR Signaling
Protein Stabilization
Negative Regulation Of TOR Signaling
Inorganic Cation Import Across Plasma Membrane
Response To Nutrient Levels
Ubiquitin-protein Transferase Activity
Response To Aldosterone
Cellular Response To Nutrient Levels
Regulation Of TORC1 Signaling
Dendritic Spine Morphogenesis
Cellular Response To Acidic PH
Negative Regulation Of Autophagy
Protein K48-linked Ubiquitination
Intracellular Sodium Ion Homeostasis
Ubiquitin-dependent Protein Catabolic Process
Sodium Ion Import Across Plasma Membrane
Response To Acidic PH
Protein K6-linked Ubiquitination
Cellular Response To PH
Negative Regulation Of Neural Precursor Cell Proliferation
Multicellular Organismal-level Water Homeostasis
Import Across Plasma Membrane
Positive Regulation Of Excitatory Postsynaptic Potential
Dendritic Spine Organization
Negative Regulation Of Potassium Ion Transmembrane Transport
Sodium Ion Import Across Plasma Membrane
Sensory Perception Of Salty Taste
Negative Regulation Of Potassium Ion Transport
Import Into Cell
Negative Regulation Of Potassium Ion Export Across Plasma Membrane
Cellular Response To Aldosterone
Sodium Channel Complex
Sensory Perception Of Sour Taste
Cellular Response To Vasopressin
Potassium Channel Inhibitor Activity
Transmembrane Transporter Binding
Regulation Of Potassium Ion Export Across Plasma Membrane
Cellular Response To Mineralocorticoid Stimulus
Ligand-gated Sodium Channel Activity
Regulation Of Potassium Ion Transmembrane Transport
Regulation Of Sodium Ion Transport
Sodium Ion Transport
Negative Regulation Of Cation Transmembrane Transport
Response To Aldosterone
Negative Regulation Of Monoatomic Ion Transmembrane Transport
Cellular Response To Acidic PH
Regulation Of Potassium Ion Transport
Intracellular Sodium Ion Homeostasis
Inorganic Cation Import Across Plasma Membrane
Negative Regulation Of Monoatomic Ion Transport
Response To Acidic PH
Ubiquitin-protein Transferase Activity
Cellular Response To PH
Negative Regulation Of Transmembrane Transport
Sensory Perception Of Taste
Sodium Channel Activity
Sodium Ion Homeostasis
Neuromuscular Junction Development
Response To Mineralocorticoid
Sodium Ion Transmembrane Transport
Response To PH
Import Across Plasma Membrane
Regulation Of Metal Ion Transport
Ubiquitin Protein Ligase Activity
Protein Modification By Small Protein Conjugation
Protein Monoubiquitination
Regulation Of Monoatomic Ion Transport
Regulation Of Membrane Potential
Sodium Channel Inhibitor Activity
Regulation Of Dendrite Morphogenesis
Endocytosis
Cellular Response To Corticosteroid Stimulus
Receptor Internalization
Protein K63-linked Ubiquitination
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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