HECW1

Gene Name		HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
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Gene Ontology Annotations	Cellular Component	Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Ligase Activity
	Biological Process	Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN degradation of DVL Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Obesity-related traits ( 23251661)
Protein-protein Interactions		10 interactors: CACNA1A DVL1 GFI1B SCNN1A SCNN1B SSR4 TNK2 TP53 UBC USP7
Entrez ID		23072
HPRD ID		11385
Ensembl ID
Uniprot IDs		B4DH42 Q76N89
PDB IDs		3L4H
Enriched GO Terms of Interacting Partners?		Membrane Organization Sodium Ion Homeostasis Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Transport Excretion Multicellular Organismal Water Homeostasis Negative Regulation Of Catalytic Activity Receptor Clustering DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Water Homeostasis Sensory Perception Of Taste Transcription From RNA Polymerase II Promoter Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Protein Localization To Membrane Positive Regulation Of Cell Cycle Arrest Cerebellar Molecular Layer Development DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Protein Catabolic Process Dendrite Morphogenesis Regulation Of Cellular Component Organization Signal Transduction In Response To DNA Damage Regulation Of Protein Phosphorylation Nucleotide-excision Repair Mitotic DNA Damage Checkpoint Regulation Of Cell Cycle Arrest Establishment Of Localization In Cell Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Hypoxia Mitotic DNA Integrity Checkpoint Cellular Response To Decreased Oxygen Levels Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Metal Ion Homeostasis Negative Regulation Of Macromitophagy Vestibular Nucleus Development Oligodendrocyte Apoptotic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Cellular Metabolic Process Neurological System Process Neurotransmitter Secretion Growth Cellular Response To Oxygen Levels
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